Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 325 for “"STAT"”.
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Regulation of STAT-3 and STAT-6 by Transient Oxidative Stress in Rat Brain Astrocytes
"STAT family of transcription factors mediate in a variety of cellular processes, such as immune response, differentiation, cell survival, proliferation, or oncogenesis, following a series of extracellular signaling such as cytokine, growth factor, and hormone signaling. Accumulating evidence also …
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Inactivation of the JAK-STAT Pathway
… Transducers and Activators of Transcription (STATs) play an important role in cytokine-induced gene transcription. Aberrant stimulation of this pathway can lead to abnormal development and cellular transformation demonstrating the importance of understanding mechanisms of downregulation. After …
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The Role of STAT and the Jak/STAT Pathway In Mediating the Effects of Interleukin-6 on StAR Expression
… of ACTH parallel those of cortisol. However, in states of chronic stress, the level of ACTH drops dramatically, while cortisol remains high. This study focuses on the pathway of cortisol release during these chronic stress states, specifically examining the role of IL-6 with respect to STATs and …
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was designed to determine the role of histamine in the regulation of ST ATI …
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Jak-stat pathway in the control of mycobacterial infections
Though mammalian JAKs and STATs have been extensively studied over the past 20 years, many aspects of their in vivo function remain unclear. In particular, their roles in control of infection with pathogens remain murky and confusing. One difficulty in understanding how these pathways regulate …
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Signaltransduktion durch JAK/STAT-Moleküle bei der Polyzythämia vera
… verwendete, Signaltransduktionsfaktoren - STAT1, STAT3 und JAK2 - näher untersucht. Es zeigte sich eine konstitutive Aktivierung von STAT3 in 4 von 14 Patienten mit Polyzythämia vera.
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Signal Transducer and Activator of transcription-1 (STAT-1) und STAT-1 assoziierte Proteine (MCM3,MCM5) in epithelialen Ovarialkarzinomen : Expressionsanalysen und Prognostische Relevanz
… transducer and activator of transcription-1“ (STAT1) und STAT1-assoziierter Moleküle („minichromosome-maintenance“: MCM-3, -5) in epithelialen Ovarialkarzinomen des Stadiums IIIc zu untersuchen und auf ihren prognostischen Wert hin zu überprüfen. <br>Dazu wurde auf RNA- und Protein-Ebene die …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
The Jak/Stat signaling cascade mediates cell proliferation, differentiation, survival, apoptosis and immune responses. Aberrant activation of this pathway mediates neoplastic transformation and abnormal growth of many malignancies including breast cancer, the most common cancer among women, and the …
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Stat och kommun i makt(o)balans : En studie av flyktingmottagandet
… point of departure and are, to a large degree, static in their approaches, which means that they risk not discovering, or have problem explaining, changes in the relation between central and local government. To view the relationship between central and local government as interdependence leads …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… transducer and activator of transcription (JAK/STAT) signaling, and particularly JAK2-dependent signaling, contributes to cochlear resilience during aminoglycoside ototoxic stress. To nominate candidate pathways, early gentamicin-responsive hair-cell transcriptomic data were integrated with …
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Το Jak stat μονοπάτι στην παθογένεση και θεραπεία της ατοπικής δερματίτιδας
ΕΙΣΑΓΩΓΗ: Η ατοπική δερματίτιδα αποτελεί τη συχνότερη χρόνια φλεγμονώδη νόσο του δέρματος. Στο προσβεβλημένο δέρμα παρατηρείται αυξημένη έκφραση Th2, Th17, Th22 και Th1 κυτταροκινών. Στο πλαίσιο της αυξανόμενης εφαρμογής στοχευμένων θεραπευτικών προσεγγίσεων, κατά αναλογία με την ψωρίαση, οι …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in cell migration, metastasis, proliferation, survival, and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and …
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Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries
… transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in ischaemic preconditioning to promote cell survival but whether …
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Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors
Background: The JAK-STAT pathway is a cellular signaling pathway, which acts normally in humans and animals in the control of multiple important functions. Dysregulation of this pathway has been identified in human cancers, as well as a limited number of veterinary cancers. Objectives: The aims of …
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Instructional Technology Experiences of Student Teachers: A Case Study of Participants in the STAT Internship Program
… preservice training and inservice teaching. The STAT Internship Program is an alternative internship program that emphasizes the use of instructional technology. A case study of seven participants in the STAT Internship Program was chosen to investigate five research questions. The research …
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The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning
Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial infarction. This protective phenomenon that lessens myocardial infarction can be mimicked by the cytokine …
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Investigating how Notch, and JAK/STAT Signaling Synergistically Regulate Intestinal Stem Cell Homeostasis Using Engineered Optogenetic Alleles
… or differentiation. The Notch, and JAK/STAT signaling pathways are central regulators of multicellular development and are vital for tissue maintenance. The interplay between the Notch, and JAK/STAT pathways required for tissue homeostasis has not been fully elucidated, particularly as …
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The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological postconditioning
Includes abstract. Includes bibliographical references (leaves 131-147).
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