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Showing 1 to 19 of 19 for “"ST131"”.
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Phenotypic, Genotypic, and Pathogenic Evaluation of E. coli ST131 Clinical Isolates
Since their identification in 2008, E. coli ST131 isolates have become a major cause of cystitis and pyelonephritis. However, these strains are not known to encode different, or increased numbers of virulence factors compared to other sequence types of pathogenic E. coli. To date, no data in the …
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Determining the fitness and competitive advantage of the epidemic ExPEC clone E. coli ST131
… The emergence of the CTX-M producing E. coli ST131 clone represents a major challenge to public health worldwide because of its ability to cause a wide range of difficult-to-treat infections in the healthcare and community settings. The key aim of this study was to characterise the traits that …
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Caracterización epidemiológica y clínica de la infección y colonización por Escherichia coli perteneciente al complejo clonal O25b/ST131
Introducción. Escherichia coli secuenciotipo 131 (ST131) es un clon que combina capacidad de propagación exitosa, resistencia a los antibióticos y virulencia; de hecho, los aislamientos de ST131 generalmente exhiben los factores de virulencia asociados característicos de las cepas de E. coli …
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Outer Membrane Porin Regulation among Different Sequence Types of Escherichia coli Clinical Isolates
Escherichia coli sequence type 131 (ST131) is a successful pandemic clone associated with the spread of β-lactam and fluoroquinolone resistance. However, the reasons for the global dominance of this clone are largely unknown. It has been suggested that the success of ST131 E. coli is due to the …
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Escherichia Coli ST131 Collected From Companion Animals Can Cause Cystitis and Pyelonephritis in a Murine Model of Urinary Tract Infection
… Since the mid- 2000s, a subset of UPEC called ST131 have undergone rapid pandemic spread. ST131 are a major cause of UTIs that lead to serious complications in humans like pyelonephritis and sepsis. In companion animals, ST131 infections rarely cause severe symptoms, but are underreported as …
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Diversidad de Beta-lactamasas de espectro extendido y de líneas genéticas en aislados de Escherichia coli de diferentes ecosistemas en La Rioja
… 2006 se comenzó a detectar el clon CTX-M-15-B2-ST131. Los grupos filogenéticos mayoritarios en estas cepas fueron el A, B2 y D. A continuación se analizó la frecuencia de detección de E. coli BLEE+ en muestras fecales de pacientes (n=99) y de personas sanas (n=115), detectándose estos …
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Characterization of antimicrobial resistance among canine urinary isolates in Western Canada
… single isolate belonging to the pandemic lineage ST131 was identified. Conclusion: Canine urinary E. coli in Saskatchewan remain largely susceptible to first line therapies, though resistance, particularly to the aminopenicillins, warrants continued monitoring. Fosfomycin represents a viable …
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Computational analysis of Escherichia coli O25 and O25b carbohydrate antigens using the CHARMM36 and GLYCAM06 force fields
The emergence of ST131 extra-intestinal pathogenic Escherichia coli that are resistant to multiple antibiotics is a growing international health concern. Infections are common, treatment options for antibiotic resistant bacteria are limited and there is no vaccine available. Polysaccharides serve …
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GENOMIC SURVEILLANCE AND RISK-BASED ASSESSMENT OF ANTIBIOTIC RESISTANCE TRANSMISSION ACROSS TROPICAL AQUATIC ENVIRONMENTS
… element–pathogen linkage. High-risk clones (ST131, ST147) carrying clinically significant resistance genes (CTX-M-15, NDM-19) were shared between clinical and sewage sources, while downstream environments showed progressive linkage disruption. These findings establish a scalable surveillance …
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Epidemiología molecular en Escherichia coli procedente de fauna salvaje: resistencia antimicrobiana, virulencia y diversidad y diversidad genética
… among humans, domestic animals and food (ST131, ST10, ST155, ST224, ST38, ST57), which support the existence of successful lineages strongly associated with the bidirectional dissemination of ESBL/AmpC genes. Cryptic Escherichia clades were identified in various wild mammals, highlighting …
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Epidemiología molecular en Escherichia coli bajo el concepto One Health: filogenómica, dinámica plasmídica de beta-lactamasas emergentes y patogénesis de interés en salud pública
… como ST117 y el clon pandémico de alto riesgo ST131. Simultáneamente, en el ganado porcino se describe la presencia del gen de resistencia a colistina mcr-4 en la microbiota nasal de animales sanos. Este hallazgo pone de manifiesto el riesgo de mantenimiento silente y transmisión de mecanismos …
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The Nature of Uropathogenic Escherichia coli ST127
… many of the leading uropathogenic lineages (cf. ST131) using an established uropathogenic PCR virulence assay. This study explores the contradictory nature of these findings by evaluating some of the major aspects concerning the diagnosis, genomic repertoire and pathogenicity of strains of this …
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Comparative genotypic and phenotypic characteristics of human associated extraintestinal Escherichia coli isolated from cats and dogs
… ExPEC sequence types (ST) (ST69, ST73, ST95 and ST131) within phylogroups B2 and D, could be isolated from faeces collected from healthy domestic cats and dogs in Canberra. This was especially the case for cats and ST73. This ST was isolated from a greater proportion of cat faecal samples than …
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Comparative genotypic and phenotypic characteristics of human associated extraintestinal Escherichia coli isolated from cats and dogs
… ExPEC sequence types (ST) (ST69, ST73, ST95 and ST131) within phylogroups B2 and D, could be isolated from faeces collected from healthy domestic cats and dogs in Canberra. This was especially the case for cats and ST73. This ST was isolated from a greater proportion of cat faecal samples than …
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Multiple levels of regulation are associated with the production of CTX-M-14 and CTX-M-15 beta-lactamases in Escherichia coli
… with the uropathogenic clone, sequence type 131 (ST131) that combines both virulence and multi-drug resistance mechanisms. The goal of my research was to understand the molecular mechanism(s) that contributes to CTX-M-mediated resistance with a focus on the two most dominant allotypes. Such …
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Populations of Escherichia coli in clinical samples of Urinary Tract Infections and bacteraemia
… a small number of dominant sequence types (STs) (ST131, ST73, ST95) which is associated with ESBL conferred multi drug resistance and not specific virulence genes. This suggests that the increased prevalence of ESBL carriage in ExPEC isolates is leading to a selective advantage in a small number …
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Genomics and host response of S. Typhi infections
… monoclonal antibody against the E. coli ST131 specific O-antigen were defined. This method can be used in the future to evaluate Salmonella serovar specific O-antigen monoclonal antibodies.
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Molecular epidemiology of the multidrug-resistant Escherichia coli sequence type 131-H30 lineage among U.S. children
Escherichia coli sequence type 131-H30 is a globally important pathogen implicated in rising rates of antimicrobial resistance among extraintestinal E. coli infections. H30 causes both community- and healthcare-associated infections, and is associated with resistance to several commonly used …
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Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
… eight isolates belonging to the high-risk clone ST131. A synergistic sensitization effect was found for ciprofloxacin when the SOS response (recA gene) and detoxification or stress regulatory systems were suppressed. However, this effect was not always replicated for other fluoroquinolones. …