Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"SSRIs"”.
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The Effect of SSRIs on Adult Human Visual Cortex Plasticity. Do SSRIs Affect learning?
… Selective serotonin reuptake inhibitors (SSRIs) have been shown to enhance visual cortex plasticity in adult animals (Maya-Vetencourt, Sale et al. 2008). The aim of this study was to assess whether SSRIs increase visual cortex plasticity in humans. Methods: To test healthy visual …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
… of serotonin-selective reuptake inhibitors (SSRIs). A variety of potent analogues of meperidine have been synthesized and evaluated in vitro as potential ligands for the serotonin transporter. Substitutions have been made on the aryl ring, the ester moiety and the piperidine nitrogen of …
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An In Vitro Characterization of the Raphe Nucleus and the Effects of SSRIs on Synaptic Neurotransmission
Antidepressants are traditionally used in the treatment of depression. While these drugs rapidly inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, clinical efficacy can take several weeks. This phenomenon implies that …
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A preliminary study of the effects of selective-serotonin re-uptake inhibitors (SSRIs) on central auditory processing
his study compared auditory behavioral and physiological measures among three subject groups: 1) Normal control subjects, 2) subjects who were on a prescribed SSRI for depression, and 3) subjects who were prescribed an SSRI for depression, but were not medicated at the time of testing. Test …
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ASSOCIATION BETWEEN CONCOMITANT USE OF BISPHOSPHONATES AND SEROTONIN REUPTAKE INHIBITORS AND INCREASED RISK OF OSTEOPOROTIC-RELATED FRACTURES: AMONG COMMUNITY-DWELLING POSTMENOPAUSAL WOMEN
… and selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) are commonly used medications to treat these conditions. Inhibitory effects of BPs on osteoclasts are responsible for the reduction in fracture risk. SSRIs, however, are associated with …
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The elderly, arginine vasopressin & selective serotonin reuptake inhibitors
… between selective serotonin reuptake inhibitors (SSRis) and hyponatraemia has been well documented, the elderly appearing to be at greatest risk. An analysis of data of hyponatraemia in the elderly using SSRis from all published cases and from the Committee on Safety of Medicines found that the …
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Comparative Effectiveness of Second Generation Antidepressants on Cognition and Dementia in the Elderly
… namely Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs) or Tetracyclics. These patients were followed for one year to examine cognition; and two years to evaluate the risk of dementia. Cognition was identified using the MDS Cognition scale. …
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Efficacy and safety of serotonin reuptake inhibitors (SSRI) and serotonin noradrenaline reuptake inhibitors (SNRI) for children and adolescents with anxiety disorders: A systematic review and meta-analysis
Selective serotonin reuptake inhibitors (SSRIs) are considered to be the first-line pharmaco-logical treatment of anxiety disorders in children and adolescents. Selective serotonin noradrenaline reuptake inhibitors (SNRIs) have also been proven to be effective. This study conducts a systematic …
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The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study
… such as selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet activity. However, previous evidence regarding the cardiovascular effects of these agents has been conflicting. There is a need …
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Characterization of an Evolving Serotonin Transporter Computational Model
… transporter (SERT). Established SERT inhibitors (SSRIs) were docked to an in silico SERT model to identify likely binding pocket amino acid residues. When mutated singly, no one of five implicated residues was critical for high affinity in vitro binding of SSRIs or cocaine. The in silico SERT …
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Pharmacological Characterization of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening
… The selective serotonin reuptake inhibitors (SSRIs) have been the mainstay of pharmacotherapies for depression for the last 40 years. The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating serotonergic neurotransmission. The SSRIs are not …
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… with selective serotonin reuptake inhibitors (SSRIs). SSRIs typically express many pharmacological effects through inhibiting serotonin (5-HT) transporters; however, due to delayed and inadequate treatment effects, other treatment methods should be pursued. Alternative drug treatments acting on …
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Economic evaluations of antidepressant treatments: a national cohort study in Taiwan
… of the selective serotonin reuptake inhibitors (SSRIs) and subsequently, other novel antidepressant agents with different pharmacological mechanisms entered the market. <br/>Given the range of choices, clinicians must decide about which is the most<br/>appropriate intervention for their patients. …
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The Role of the Serotonergic Neurotransmitter System in the Development and Treatment of Affective Disorders
… Serotonin selective reuptake inhibitors (SSRIs) are frontline therapy for both of these conditions, and have well-described behavioral effects in animal models of emotional behavior. Yet, administration of SSRIs during postnatal development produces an opposing phenotype, including …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… (i.e., selective serotonin reuptake inhibitors (SSRIs)) in animal models prior to sexual maturation. This is a scientific and clinically relevant issue as (1) SSRIs, the most effective pharmacological option for treating mood disorders in children and adolescents, are being increasingly …
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
… (SERT). Since blood platelets express SERT, SSRIs may modify platelet function and the risk of cardiovascular disease. However, the beneficial or adverse effects of SSRIs on arterial thrombosis are poorly characterised and detailed in vitro experimental data is limited. The SSRI citalopram is …
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The Roles of Inflammation, Oxidative Stress, and Neurotransmitters in an Animal Model of Post-Traumatic Stress Disorder
… inhibitor (SSRI) sertraline to ascertain why SSRIs have historically been ineffective in treating PTSD. Taken together, our findings indicate inflammation, oxidative stress, and aberrant neurotransmitter profiles may play a significant role in PTSD development and progression. In addition, VA …
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Pharmacotherapy for Social Anxiety Disorder and Posttraumatic Stress Disorder: New Meta-Analytic Approaches to Synthesising the Evidence
… most convincing for the treatment efficacy of SSRIs (number of studies (k) = 24, risk ratio (RR) 1.65; 95% confidence interval (CI) 1.48 to 1.85, N = 4984 and k = 8, RR 1.61; 95% CI 1.41 to 1.84, N = 1078, respectively), and was based on very low quality evidence. Evidence of a benefit for the …
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Complications to peptic ulcer and peptic ulcer surgery
… and selective serotonin re-uptake inhibitors (SSRIs) on outcome after PUB and on localization of gastrointestinal (GI) bleed by evaluation of all hospitalizations of GI bleed at the Department of Surgery in Lund 1984, 1994 and 2004. I) A progression was found of premalignant changes (atrophy, …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… are selective serotonin reuptake inhibitors (SSRIs), though only about 50% of patients respond to this treatment. Previous work in our lab demonstrated the combination of chronic fluoxetine (FLX) and acute ketamine treatment decreased fear response in a contextual fear paradigm in male C57/BL …
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