Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"SRY"”.
-
Specific binding of human SRY (Sex-Determining Region Y) to DNA adducts of the anticancer drug cisplatin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
-
Characterization of novel DNA binding activities at the immunoglobulin 3' enhancer
… indicating their evolutionary significance. SRY, SpiB, LM02, and Rzra have been shown elsewhere to bind recognition sequences found within the evolutionarily conserved regulatory elements of this enhancer. We seek to demonstrate previously unreported individual and cooperative DNA binding …
-
Sizing the first flush and its effect on the storage-reliability-yield behavior of rainwater harvesting in Rwanda
… for the water. The storage-reliability-yield (SRY) behavior of a rainwater harvesting system indicates trends in reliability as storage (cistern size) and yield (demand) are varied. A SRY simulation model was run to mimic daily use of the system and calculate the reliability. The recommended …
-
Identification of TMEM2 as a SOX4 Transcriptional Target Involved in Breast Cancer Metastasis
<p>The transcription factor SRY (sex determining region Y)-box 4 (SOX4) regulates embryonic development and has been shown to drive the progression and metastasis of multiple solid cancer types. A common transcriptional target of SOX4 that mediates its effects in multiple cancer types has yet to be …
-
Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… gene expression. Finally, I showed that Sox9, an SRY-related transcription factor, is a critical downstream mediator of PDGF signaling. This body of work establishes PDGF signaling as a key EMT regulatory pathway and suggests a novel role for Sox9 in regulating EPDC development.
-
Investigations Of The Effects Of Selected Y-chromosome Encoded Gene Deletion And Viral Infection On Testicular Function In A Mouse Model
… Y-chromosome encoded testis determining factor, Sry, and viruses that transmit vertically, like ZIKA virus (ZIKV). Zinc finger Y encoded genes (Zfy), termed Zfy1 and Zfy2 in mouse and ZFY in humans, were once suspected to be the testes determining factor (TDF). This was proven incorrect when the …
-
Sexual differentiation of somatic and germ cell lineages of the mouse gonad
… the identification of a few key genes such as Sry and Sox9. To further our understanding of gonad organogenesis, a PCR based subtractive hybridization was performed to identify mouse genes that demonstrate sexually dimorphic expression patterns during embryonic development of the testis and …
-
Apport de données d’ADN nucléaire à la Phylogénie et à la Biologie de la Conservation des Ursidae
… In addition, based on the study of the genes SRY (Sex determining region of the Y chromosome), ZFX/ZFY (Zinc Finger protein) and AMLX/AMLY (Amelogenine), we developed a reliable method to determine the sex of Ursidae based on the analysis of DNA extracted from non invasive samples such as …
-
<i>PTHR1/SOX9</i> and <i>IDH1/IDH2</i> Relative Expression in Primary Chondrocyte and Chondrosarcoma Cells Under the Synergistic Influence of Inducible Hypoxia and Extracellular Acidosis
… parathyroid hormone receptor-1 (<em>PTHR1</em>), SRY-box transcription factor 9 (<em>SOX9</em>), and isocitrate dehydrogenase 1 and 2 (<em>IDH1/IDH2</em>). <em>PTHR1</em> and SOX9 keep chondrocytes in a proliferative state and delay their hypertrophy. On the other hand,<em> IDH1</em> and …
-
Structural Studies of a Non-Sequence-Specific DNA Binding Protein, Hmg-D, Complexed With DNA
… vs. non-specific manner: LEF-1 and SRY fall into the former category while the latter is exemplified by HMG-1/2 and by HMG-D, a non-histone chromosomal protein from Drosophila melanogaster. Regardless of specificity, these proteins adopt a conserved 'L' shaped, three helix DNA …
-
Regulation der BOB.1/OBF.1-Expression und der BOB.1/OBF.1-Proteinstabilität
… die Transkriptionsfaktoren CREB, NF-AT und ein SRY-Motiv. In Transfektionsstudien konnte eine deutliche Zellspezifität des Promotors gezeigt werden. Die erwartete induzierbare Aktivierung in T-Zellen war hingegen nur schwach. Die Analyse der BOB.1/OBF.1-Regulation in B-Zellen des Keimzentrums …
-
Entwicklung transgenbasierter Systeme zur Anwendung im Rahmen der Sterilen Insekten Technik, einer ökologisch verträglichen Schädlingsbekämpfungsmethode
… der Zellularisierungsgene serendipity alpha (sry alpha) und nullo ausgewählt, die ausschließlich in einem engen Zeitfenster während der frühen Embryonalentwicklung aktiv sind. Diese Regulatorsequenzen steuern die Genexpression des tetracyclinkontrollierten Transaktivators tTA. Zur Erzeugung …
-
Delineating the molecular mechanisms regulating chondrogenesis
Sox9, (SRY-type HMG box), has been shown to play a critical role throughout chondrogenesis. Haploinsufficiency of Sox9 in humans leads to a skeletal malformation syndrome known as campomelic dysplasia. To understand the regulation of Sox9 during chondrogenesis, the developing mouse limb was used to …
-
The Role of SOX2 in Colon Cancer Progression
SRY (sex determining region Y)-box 2 (SOX2) is one the embryonic stem cell transcription factors that is capable of reprogramming adult differentiated cells into an induced pluripotent cell. SOX2 is amplified in various types of epithelial cancers and its high its expression correlates with poor …
-
Caractérisation de l'expression des facteurs de transcription des groupes SOXD et SOXE au niveau du testicule chez la souris
"Les facteurs de transcription Sox (SRY-related box) sont une famille de protéines fortement conservées chez les vertébrés. Elles régulent plusieurs processus de développement incluant la détermination et la différenciation sexuelle chez l'embryon mâle. Il est bien connu que certains …
-
Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… systematically characterise the function of two SRY-related HMG-box (SOX) genes, SOX2 and SOX9, in human foetal lung progenitor cells. I show that although SOX2 is expressed in early stage progenitor cells it is dispensable for progenitor cell survival and self- renewal. By contrast, SOX9 is …
-
Estimating Population Numbers of Black Bears (Ursus Americanus) in Eastern Kentucky Using Microsatellite Analysis
… obtained. Eight microsatellite markers and one SRY marker were used to genotype and determine the sex of individual black bears. A minimum of thirty- nine different individuals (26 males and 13 females) were identified during the study period. Most of the individuals were identified during June …
-
Dissecting adult epithelial cell plasticity using a model of oesophageal-to-skin lineage conversion
… factor-1α (HIF1a) and its downstream target SRY-box transcription factor 9 (SOX9). These results unveiled that the HIF1a-SOX9 axis poses a barrier to oesophageal-to-skin lineage conversion. In turn, when this barrier is lifted cells respond better to the dermal signals instructing alternative …
-
The role of beta-catenin in the development of fetal ovary and female germ cells
… default process, arising only in the absence of Sry, a testis-determining gene. However, current evidence has suggested the presence of an active pathway in fetal ovary. In particular, gene screening experiments have shown that many genes are expressed specifically in ovary. Wingless related …
Page 1 of 2