Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"SRSF2"”.
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RNA modifications and processing in cell homeostasis and in response to oxidative stress
… NSun2 and the alternative splicing factor Srsf2 are linked to neurological disorders and cancer in humans, respectively. NSun2 methylates cytosine-5 in most tRNAs and, to a lesser extent, other ncRNAs and mRNAs. Srsf2 is a critical component of the spliceosome and interacts with abundant …
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BIOINFORMATICS ANALYSIS OF FULL-LENGTH RNA NANOPORE SEQUENCING AT SINGLE CELL LEVEL TO STUDY TRANSCRIPTIONAL AND MUTATIONAL PATTERNS IN HUMAN LEUKEMIA
… SCM-seq was employed to analyze AML samples with SRSF2 spliceosome-factor gene mutations, elucidating the relationship between genetic complexity and transcriptional heterogeneity in malignant and immune compartments. The results confirmed the efficacy of SCM-seq in achieving high-throughput …
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Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing
… pre-mRNA and identified two candidate proteins, SRSF2 and SRSF3, that may be involved in VEGF- or FGF2-induced Flt1 pre-mRNA splicing. Examination of SRSF2 and SRSF3 relative mRNA expression levels, following inhibition of VEGF- and FGF2-activated kinases, indicates that FGF2 significantly …
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Su onkologinėmis ligomis siejamas pre-iRNR splaisingas: splaisingo veiksnių ir hipoksinės mikroaplinkos tyrimas /
… shown differences in the expression of SRSF1, SRSF2, U2AF65, U2AF35 and KHSRP splicing factors and tumor-associated Fas and Rac1 mRNA isoforms in tumor tissues and commonly used tumor cell lines. Our results indicate that reduced oxygen content in the cell environment (hypoxia) affects Fas …
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INTEGRATED SINGLE-CELL MUTATION, GENE EXPRESSION AND ISOFORM ANALYSIS TO DECONVOLVE ACUTE MYELOID LEUKEMIA HETEROGENEITY
… complexity. In all lineages, the presence of the SRSF2 mutation was associated to increased isoforms diversity, with mutated cells carrying significantly higher proportions of genes expressed with more than one isoform or expressing novel or alternative transcripts, as compared to AML …
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PU.1-ACTIVATED GENOMIC REGIONS DEFINE LOW-RISK MDS SUBSETS CHARACTERIZED BY IMMUNE DYSREGULATION AND DISEASE PROGRESSION
… and NK activation, and a higher frequency of SRSF2 mutations. Clinically, patients in this group exhibit greater susceptibility to infections and cardiovascular events, along with an elevated risk of disease progression, resulting in a significantly reduced overall survival. Functional studies …
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The natural history of clonal haematopoiesis
… ranging from 5% (DNMT3A, TP53) to over 50%/yr (SRSF2-P95H). Growth rates of clones with the same mutation differed by +/-5%/yr, proportionately impacting “slow” drivers more substantially. Combining these time-series data with phylogenetic analysis of 1,731 whole genome-sequenced haematopoietic …
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Determinants of clinical phenotype in myeloproliferative neoplasms
… a set of mutations that included ASXL1, SRSF2, U2AF1 and EZH2 was enriched in myelofibrosis and associated with poor outcomes. The JAK2 46/1 haplotype strongly correlated with the presence of 9pUPD and independently with a PV phenotype, demonstrating that the underlying germline …
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Modelling the age-dependent dynamics of clonal haematopoiesis
… of 40. In contrast, expansion of clones carrying SRSF2, SF3B1, and IDH2 variants showed no evidence of deceleration, consistent with previous findings. The evolutionary model was adapted to test two potential explanations for this deceleration. Firstly, variation in fitness between individuals …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
… in splicing factor genes (namely SF3B1, SRSF2, and U2AF1) are frequent drivers of CH, particularly in the elderly, and confer a high risk of progression to haematological malignancy. Despite over a decade of research into CH, we still lack an understanding of the mechanisms through which …
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Functional analysis of KLF2 and its lymphoma-derived mutants
… suggested colocalisation between mutant KLF2 and SRSF2, a component of the spliceosome, suggesting that KLF2 may also be involved in splicing and RNA processing activities. Gene expression profiling showed that wild type and mutant KLF2 regulate many of the same genes that are involved in …