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Showing 1 to 6 of 6 for “"SRSF1"”.
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Elucidating the role of SRSF1, a prototypical splicing factor, in liver physiology
… focuses on understanding the functional role of SRSF1, a prototypical splicing factor, in the context of liver physiology. I began by generating and characterizing hepatocyte-specific SRSF1 knock-out mice models. These mice developed severe liver damage and exhibited pathology like the human …
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Su onkologinėmis ligomis siejamas pre-iRNR splaisingas: splaisingo veiksnių ir hipoksinės mikroaplinkos tyrimas /
… work have shown differences in the expression of SRSF1, SRSF2, U2AF65, U2AF35 and KHSRP splicing factors and tumor-associated Fas and Rac1 mRNA isoforms in tumor tissues and commonly used tumor cell lines. Our results indicate that reduced oxygen content in the cell environment (hypoxia) affects …
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Régulation de l’épissage alternatif par un complexe de facteur d’épissage et annotation fonctionnelle de l’épissage alternatif
… que RBFOX2 peut interagir avec hnRNPC, hnRNPM et SRSF1 et se lie à l'ARN en utilisant leurs motifs. Nous avons montré que ces protéines régulent l'épissage alternatif en fonction de la configuration de leur interaction avec le pré-ARNm, et ciblent des gènes de différentes fonctions. Pour mieux …
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Genomic studies of oocyte physiology reveal mechanisms critical to oocyte competence
… and 4 other genes, TNF, PERV, TL10 and SRSF1, were differentially expressed between adult (more competent) and prepubertal (less competent) porcine in vitro matured oocytes. These genes were further analyzed by comparing transcript abundance in in vitro and in vivo matured prepubertal …
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Translational control mechanisms in the p53 response network
… (AUF1) and CPEB4 are direct p53 targets, whereas SRSF1, DDX17, YBX1 and TARDBP are indirect targets, modulated at the translational level in a p53-dependent manner. In detail, we demonstrated the contribution of at least two p53-dependent translational mechanisms related to YBX1 translational …
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Mutant Kras Alters Extracellular Vesicle Microrna Sorting In Pancreatic Cystic Neoplasms
<p>Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers by organ site with a 5-year survival rate of just 10.8%. This is largely because most patients do not experience symptoms until the disease has already metastasized. The best hope to cure PDAC is surgery, which can only be …