Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"SREBPs"”.
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
… by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the proteolytic release of SREBPs from their inactive membrane bound form. Soon after translation, SREBPs bind SREBP cleavage activating protein (SCAP), a polytopic membrane protein of the endoplasmic …
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Characterization of the Functional Role of the Intracellular Cholesterol Transporter StARD4 in Knockout Mice, and Investigation of Epigenetic Modulation of ApoA-I Transcription
… by Sterol Regulatory Binding Proteins (SREBPs), Liver X Receptors (LXRs) and Unfolded Protein Response (UPR) or ER stress families of transcription factors. StARD4 is regulated by SREBPs and we have chosen to make a mouse knockout model to characterize its role in-vivo. StARD4, expressed …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… of sterol regulatory element binding proteins (SREBPs) in a cancer specific manner, leading to activation of the SREBP-FAS (fatty acid synthase) lipogenic pathway. Treatment of cancer cell lines with LPA also led to dephosphorylation and inhibition of AMP-activated kinase (AMPK), thereby …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… the sterol regulatory element binding proteins (SREBPs) and liver X receptors (LXRs). This thesis describes the identification by microarray technology of novel genes in cholesterol metabolism and the characterization of two of these genes. Microarray analysis of the livers of mice fed a low …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… in the protein that prevents it from escorting SREBPs to the Golgi for proteolytic cleavage. Scap is a 1276 amino acid protein that consists of two domains: an N-terminal domain with 8 transmembrane spanning regions and a C-terminal domain that projects into the cytosol and associates with …
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Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
… by both inhibiting the proteolytic activation of SREBPs, transcription factors for cholesterol biosynthetic genes, and enhancing the degradation of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis. We first created Insig-double-knockout (Insig-DKO) mice homozygous for null …
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Einfluss der HMG-CoA-Reduktase-Inhibitoren Atorvastatin und Lovastatin auf die Regulation der Hepatischen Lipase
… mutierten Promotorfragmenten zeigen, dass SREBPs möglicherweise an der statinabhängigen Regulation der HL beteiligt sind.
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Molecular and cellular aspects of the SREBP pathway
… biosynthesis of cholesterol and fatty acids. The SREBPs are regulated by retention or escape from the ER to the Golgi where they are proteolytically cleaved into active forms. The SREBP cleavage activating protein (SCAP) and the INSIG proteins are essential in this regulatory process. The aim of …