Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"SREBP1"”.
-
The Influence of Adenoviral Infection and the Group VIA Calcium-Independent Phospholipase A2 on Hepatic Lipid Metabolism
… dietary unsaturated fatty acid (UFA) regulate SREBP1 expression and subsequent SREBP1-mediated gene transcription, events that in many instances result in modulation of systemic fatty acid and triglyceride (TG) homeostasis. A series of investigations was designed to uncover novel regulators of …
-
Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
… sterol regulatory element binding protein-1 (SREBP1) plays a central role in milk fat synthesis. SREBP1 stimulates the transcription of genes encoding lipogenic enzymes. The overall objective of these studies was to investigate the mechanisms of SREBP1 regulation by nutrients. In the first …
-
Identification of molecular targets regulating fatty acid synthesis in bovine mammary epithelial cells
… sterol regulatory element binding protein-1 (SREBP1) and liver X receptor (LXR). In vivo, diet-induced milk fat depression or supplementing diets with polyunsaturated fatty acids inhibits milk fat synthesis by regulating SREBP1 expression. Results confirm that polyunsaturated fatty acids …
-
ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… In the next step, we detected that SREBP1, the master regulator of lipogenic genes, is also upregulated in DCIS and further identified that SREBP1 regulates the co-ordinate expression of ACLY, ACC and FAS ultimately resulting in the elevation of lipogenesis. In order to determine the …
-
Molecular and cellular aspects of the SREBP pathway
… expression and partial purification of tagged SREBP1 and SREBP2 CTDs and probing of a SCAP peptide array with the CTDs. Results from the SREBP2 probing were difficult to interpret due to insolubility issues with the protein, however, probing with SREBP1 revealed five potential binding sites …
-
Effects of dietary macronutrient composition and exogenous neuropeptide Y on adipose tissue development in broiler chicks
… element-binding transcription factor 1 (SREBP1) mRNAs in chicks fed the HF diet, whereas there was an increase in SREBP1 expression in chicks fed the HF diet after NPY injection. Expression of PPAR gamma and FABP4 mRNAs increased in the abdominal fat of HF diet-fed chicks after NPY …
-
Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol
… sterol regulatory element-binding protein 1 (SREBP1) did not show any change. AA/DHA ratios also showed a significant decrease in ATP production (P<0.01), basal respiration, maximal respiration and spare mitochondrial capacity and this effect was greater with high ratios (P<0.001). Reactive …
-
PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… associated with lipid and glucose metabolism (SREBP1/2, INSIG1, FASN, PKM2, PPARα/γ, mTOR, MAF, PDK1, LDLR, and SRB1), induced ER stress by elevating key targets in ER stress signaling (CHOP, ATF4, GRP94, GRP58, GADD 34, and PGC1α), increased glucose uptake and glycolysis due to severe nutrient …
-
THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… of free fatty acids in liver by suppressing the Srebp1 pathway. Oxidative stress also plays an important role in cadmium-induced liver injury. Nrf2-null mice are susceptible, whereas Nrf2-enhanced mice are resistant to cadmium-induced acute liver injury. Gclc, Gpx2, and Srxn-1, genes that are …