Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"SREBP-1"”.
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Regulatory factors of milk fat synthesis in dairy cows
… sterol regulatory element binding protein-1 (SREBP-1) specific siRNA. The mRNA and protein expression of SREBP-1 were decreased by more than 90% by siRNA. Fatty acid (FA) synthesis, uptake, and selected lipogenic enzyme expression were reduced in cells treated with SREBP-1 siRNA. Therefore, …
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Regulation of Highly Unsaturated Fatty Acid Metabolism
… and sterol regulatory element binding protein (SREBP)-1, are considered as the main regulators of fatty acid oxidation and synthesis, respectively, including metabolism of highly unsaturated fatty acids (HUFAs). The objective of the first project was to investigate functional differences of …
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
… Sterol Response Element Binding Protein-1 (SREBP-1) and the presence of HCV-3a core increased the processing and activity of SREBP-1. HCV core was also able to increase activity of Akt 1 and Akt2; inhibition of Akt activity resulted in decreased SREBP-1 activity thereby indicating that HCV …
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Regulation of Energy Metabolism by Fructose in the Liver
… increase in glycogen and triglycerides in liver. SREBP-1 and ChREBP, and possibly FoxO1, likely mediate gene induction by dietary fructose. The study also suggests that further ChREBP activation occurs in the nucleus after nuclear translocation of ChREBP in F-fed rat.
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… of sterol regulatory element binding proteins (SREBPs) in a cancer specific manner, leading to activation of the SREBP-FAS (fatty acid synthase) lipogenic pathway. Treatment of cancer cell lines with LPA also led to dephosphorylation and inhibition of AMP-activated kinase (AMPK), thereby …
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A Novel Subfamily of Three StAR-Related Lipid Transfer Proteins That Are Differentially-Regulated and Function in Intracellular Cholesterol Metabolism
… was preferentially activated in mouse liver by SREBP-rather than SREBP-1, supporting a role in cholesterol rather than fatty acid metabolism. X-ray crystal structure of StarD4 was solved, revealing a hydrophobic lipid binding cavity described for other START domains. StarD5 and StarD6 were …
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Efeito da proteína total digerida da semente de chia (Salvia hispânica L.) na inflamação, estresse oxidativo e saúde intestinal de camundongos alimentados com dieta hiperlipídica
… ao metabolismo lipídico: PPAR-α, AMPK, SREBP-1, CPT-1 e AMPK; estresse oxidativo: NRF2, SOD; inflamação: IL-1β e NFκB; e a quantificação hepática de IL-1β e TNF-α. Também foi avaliada a morfologia hepática, para avaliação do acúmulo de gordura no tecido. O grupo HF+DTP apresentou menor …
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The effects of Low α-Linolenic fatty acid Soybean Oil and Mid Oleic acid Soybean Oil on the growth of Her-2/neu and Fatty acid synthase over-expressing human breast cancer (SK-Br3) cells
… and sterol regulatory element binding protein-1 (SREBP-1), mitogen activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI 3-kinase) are possible down-stream effectors of Her-2/neu signaling pathway. We also evaluated the dietary effects of LLSO (20% fat of total calorie), SO (20%), …