Global ETD Search
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Showing 1 to 7 of 7 for “"SREBP pathway"”.
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Molecular and cellular aspects of the SREBP pathway
The SREBP (sterol response element binding proteins) transcription factors are central to regulating de novo biosynthesis of cholesterol and fatty acids. The SREBPs are regulated by retention or escape from the ER to the Golgi where they are proteolytically cleaved into active forms. The SREBP …
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Fatty Acid Auxotrophy in Drosophila Larvae Lacking SREBP
… finding that a lipogenic transcription factor, dSREBP (Drosophila Sterol Regulatory Element Binding Protein), is essential for the maintenance of this prototrophy. Drosophila larvae lacking dSREBP demonstrate a profound growth deficit in the second instar and die before reaching third instar. …
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Characterization of Drosophila Scap: Analysis of Mutants and Evidence for a Retention Factor
The SREBP pathway is one of the major regulators of lipid homeostasis and it is highly conserved among metazoans. SREBP is a transcription factor whose precursor is an endoplasmic reticulum (ER) transmembrane protein. In order to be activated it must travel to the Golgi apparatus via interaction …
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Structural Studies of Integral Membrane Proteins Involved in GPCR Signaling and Sterol Homeostasis
… the ER membrane. Scap is a central player in the SREBP pathway, which is targeted by multiple classes of pharmaceuticals, including statins. Through efforts described in the second half of this dissertation, I have been able to demonstrate the first biochemical characterization of the full-length …
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Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
… sterol regulatory element binding protein (SREBP). SREBP requires release of the amino terminus from the membrane to activate transcription of genes involved in cholesterol and fatty acid synthesis. In response to low sterol levels, Scap escorts SREBP from the ER to the Golgi where it is …
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Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
… sterol regulatory element binding protein (SREBP). SREBP requires release of the amino terminus from the membrane to activate transcription of genes involved in cholesterol and fatty acid synthesis. In response to low sterol levels, Scap escorts SREBP from the ER to the Golgi where it is …
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Oxysterol Signature as Putative Biomarker in Niemann-Pick Type C and Inflammatory Bowel Diseases
… takes place by the mean of four different pathways. The first is the inhibition of the commonly activated sterol regulatory element binding protein (SREBP) pathway and the second is the activation of liver X receptors α and β (LXRα and LXRβ). The third action of oxysterols is the …