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Showing 1 to 20 of 38 for “"SREBP"”.
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Fatty Acid Auxotrophy in Drosophila Larvae Lacking SREBP
… finding that a lipogenic transcription factor, dSREBP (Drosophila Sterol Regulatory Element Binding Protein), is essential for the maintenance of this prototrophy. Drosophila larvae lacking dSREBP demonstrate a profound growth deficit in the second instar and die before reaching third instar. …
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Molecular and cellular aspects of the SREBP pathway
The SREBP (sterol response element binding proteins) transcription factors are central to regulating de novo biosynthesis of cholesterol and fatty acids. The SREBPs are regulated by retention or escape from the ER to the Golgi where they are proteolytically cleaved into active forms. The SREBP …
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Combined Inhibition of SREBP and m-TORC1 Signaling Synergistically Inhibits the Proliferation of B Cell Lymphoma
Sterol regulatory element-binding protein (SREBP) signaling plays a crucial role in maintaining sterol homeostasis during B cell activation and the proliferation of germinal center B cells. It is unclear whether this pathway can be targeted to effectively treat B cell lymphoma. We discovered that …
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Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
… sterol regulatory element binding protein (SREBP). SREBP requires release of the amino terminus from the membrane to activate transcription of genes involved in cholesterol and fatty acid synthesis. In response to low sterol levels, Scap escorts SREBP from the ER to the Golgi where it is …
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Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
… sterol regulatory element binding protein (SREBP). SREBP requires release of the amino terminus from the membrane to activate transcription of genes involved in cholesterol and fatty acid synthesis. In response to low sterol levels, Scap escorts SREBP from the ER to the Golgi where it is …
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Regulatory factors of milk fat synthesis in dairy cows
… sterol regulatory element binding protein-1 (SREBP-1) specific siRNA. The mRNA and protein expression of SREBP-1 were decreased by more than 90% by siRNA. Fatty acid (FA) synthesis, uptake, and selected lipogenic enzyme expression were reduced in cells treated with SREBP-1 siRNA. Therefore, …
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The Influence of Adenoviral Infection and the Group VIA Calcium-Independent Phospholipase A2 on Hepatic Lipid Metabolism
Sterol regulatory element-binding proteins (SREBP) are transcription factors that regulate genes involved in lipid metabolism especially in the liver. Therefore, hepatic SREBP is significant regulator of systemic lipid metabolism. Evidence demonstrates that insulin and dietary unsaturated fatty …
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Characterization of Drosophila Scap: Analysis of Mutants and Evidence for a Retention Factor
The SREBP pathway is one of the major regulators of lipid homeostasis and it is highly conserved among metazoans. SREBP is a transcription factor whose precursor is an endoplasmic reticulum (ER) transmembrane protein. In order to be activated it must travel to the Golgi apparatus via interaction …
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Studies on cholesterol metabolism in prostate cancer cells
… (1) sterol regulatory element-binding protein 2 (SREBP-2), which increases cholesterol levels, and (2) liver X receptor (LXR), which reduces cholesterol levels. From this, we found that cholesterol accumulation was stimulated by signals that promote PCa cell-growth for example, male sex hormones …
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Regulation of Highly Unsaturated Fatty Acid Metabolism
… and sterol regulatory element binding protein (SREBP)-1, are considered as the main regulators of fatty acid oxidation and synthesis, respectively, including metabolism of highly unsaturated fatty acids (HUFAs). The objective of the first project was to investigate functional differences of …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… of a constitutively active form of SREBP-1a (SREBP-1a<super>Tg</super>), was associated with a robust induction (up to 43-fold) of hepatic apoA-IV mRNA and protein levels. In both models, a positive linear correlation between hepatic TG content and apoA-IV mRNA abundance was observed …
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
… Sterol Response Element Binding Protein-1 (SREBP-1) and the presence of HCV-3a core increased the processing and activity of SREBP-1. HCV core was also able to increase activity of Akt 1 and Akt2; inhibition of Akt activity resulted in decreased SREBP-1 activity thereby indicating that HCV …
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A Novel Subfamily of Three StAR-Related Lipid Transfer Proteins That Are Differentially-Regulated and Function in Intracellular Cholesterol Metabolism
… was preferentially activated in mouse liver by SREBP-rather than SREBP-1, supporting a role in cholesterol rather than fatty acid metabolism. X-ray crystal structure of StarD4 was solved, revealing a hydrophobic lipid binding cavity described for other START domains. StarD5 and StarD6 were …
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
… by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the proteolytic release of SREBPs from their inactive membrane bound form. Soon after translation, SREBPs bind SREBP cleavage activating protein (SCAP), a polytopic membrane protein of the endoplasmic …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… of sterol regulatory element–binding protein (SREBP) localization, a transcription factor that regulates key enzymes for cholesterol synthesis. SREBP cleavage-activating protein (Scap) is the switch that controls SREBP, and therefore cholesterol synthesis. Scap senses cholesterol abundance in …
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Regulation of Energy Metabolism by Fructose in the Liver
… increase in glycogen and triglycerides in liver. SREBP-1 and ChREBP, and possibly FoxO1, likely mediate gene induction by dietary fructose. The study also suggests that further ChREBP activation occurs in the nucleus after nuclear translocation of ChREBP in F-fed rat.
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… of sterol regulatory element binding proteins (SREBPs) in a cancer specific manner, leading to activation of the SREBP-FAS (fatty acid synthase) lipogenic pathway. Treatment of cancer cell lines with LPA also led to dephosphorylation and inhibition of AMP-activated kinase (AMPK), thereby …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… and accumulation. Furthermore, the INSIG-SREBP cholesterol regulation pathway was examined after treatment with ENL and ENL-Gluc by expression analysis of genes important in cholesterol metabolism and trafficking, namely, INSIG-1, SREBP-2, HMGCoA-reductase and LDL-receptor by qPCR and …
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The Effects of Feeding Growing Female Rats Different Sources of Omega-3 Polyunsaturated Fatty Acids on Lipogenic Gene Expression and Lipid Metabolism in Liver and Adipose Tissues
… sterol regulatory element binding protein 1c (SREBP-1c) (P=0.007), and downstream enzymes, fatty acid synthase (FAS) (P=0.001) and stearoyl coenzyme A desaturase 1(SCD-1) (P=0.008). MO-fed rats had lower (P<0.001) hepatic arachidonic acid (ARA) content compared to rats fed SO, TO, and CO. Rats …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… the Sterol Regulatory Element Binding Proteins (SREBP), the Liver X Receptors (LXR), and the Unfolded Protein Response (UPR)/ER Stress Response. This thesis attempts to characterize the in vivo physiological role of novel downstream target genes of these transcription factors: StARD5 and ADAM11. …
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