Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"SRC-1"”.
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
<p>The vertebrate proto-oncogene, Src, is the prototype of a family of membrane-associated protein tyrosine kinases involved in cell signaling pathways that control cell growth, development, and differentiation. Activation of Src by mutation or overexpression has been implicated in a range of …
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Biochemical and Biophysical Studies on the Human Estrogen Receptor and Receptor Co -Regulator Interactions
These results are consistent with proposed ER-LBD/SRC-1 interaction and further the understanding of the tissue selective pharmacology seen with estrogenic and anti-estrogenic compounds.
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Analysis of the interaction between the co-chaperone p23 and the aryl hydrocarbon receptor
… with the known binding partner SRC-1. This AhR NΔ515 transactivation domain construct was used, along with amino terminal AhR deletion constructs AhR CΔ274 and AhR CΔ553, to attempt to elucidate the nature of the interaction between AhR and p23 in vitro.</p>
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Caracterización y evaluación de siete genotipos de frijol común grano color rojo (Phaseolus vulgaris L.) en la Estación Experimental La Compañía, Carazo, 2004-2005
… al rendimiento, obteniendo el mayor valor el SRC 1-12-1-43 con 2203.9 kg ha -1 , no mostrando diferencias estadísticas las demás variables relacionadas. Todos los genotipos mostraron hábito de crecimiento arbustivo indeterminado (IIb). Respecto a las variables fenológicas se observaron rangos …
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Detailed Analysis of Transcriptional Regulation by Activation Functions-1 and -2 of the Human Estrogen Receptor
… ability of the steroid receptor coactivator-1 (SRC-1) protein to facilitate the integration of the amino- and carboxyl-terminal functions of ER. We have found that SRC-1, which has been shown to significantly increase ER transcriptional activity, enhanced the interaction, mediated by either …
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A Novel Phytoestrogen that Acts as an Agonist for Human Estrogen Receptors.
… was enhance in the presense of co-activators, SRC-1 (steroid receptor coactivator-1), CBP (CREB binding proteins), and E6-AP (E6-associated protein) and inhibited by trans-4- hydroxytamoxifen (4HT). I found that 4EM was specific for ER and did not activate transcription of the progesterone …
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Small Angle X-ray Scattering study of conformational changes in steroid responsive activator (SRA) RNA upon binding with suppressor protein SHARP
… component in the steroid receptor coactivator-1 (SRC-1) acetyltransferase complex. It is<strong> </strong>needed for a response to steroid hormones by tumor cells. However, this activity is hindered by suppressive RNA binding proteins like the SMRT/HDAC1-associated repressor protein (SHARP), which …
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Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression and Hormone Regulation in Human Placental JEG-3 Cells
… Moreover, exogenous expressions of coactivators SRC-1 and CBP, independently and synergistically, upregulated the PR-A and PR-B mediated progesterone effects on the hGnRH upstream promoter in JEG-3 cells.</p> <p>Taken together, multiple cis-regulatory elements and trans-acting factors involved in …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… IL-4 promoter in the presence the coactivator SRC-1, suggesting transactivation of the IL-4 gene. Finally, therapeutic administration of gemfibrozil and fenofibrate ameliorated clinically established EAE. The data presented herein illustrate that modulation of specific transcription factors can …