Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"SRC kinase"”.
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… signal transduction pathways required for EMT. Src kinase is a non-receptor tyrosine kinase well characterized to function in growth factor as well as ECM signal transduction, but its role in epicardial cell biology is unclear. Our hypothesis is that Src kinase is a critical regulator of TGFβ …
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<i>Ixodes Scapularis</i> SRC Kinase Is Required for Rickettsial Pathogen Survival in Ticks
… in order to increase its survival in ticks. Src kinase, a non-receptor protein-tyrosine kinase, is a major player in cell signaling. Src kinase has an impact on the spread and survival of <em>A</em>. <em>phagocytophilum</em> in ticks. Studies on Src kinase in <em>I. scapularis</em> show that …
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Implication de la c-SRC kinase dans le métabolisme et la morphologie des mitochondries
… des fonctions mitochondriales. les tyrosine-kinases sont connues pour être des agents majeurs de la phosphrylation sur résidu tyrosine. Divers travaux ont montré que dans la mitochondrie, la c-Src kinase (tyrosine-kinase) cible des protéines mitochondriales et régule leurs fonctions.
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Development of Machine Learning Models for Generation and Activity Prediction of the Protein Tyrosine Kinase Inhibitors
… approaches for generation and scoring of novel kinase inhibitor molecules. We utilized a binary Random Forest classification model to develop a Machine Learning based scoring function to evaluate the generated molecules on Kinase Inhibition Likelihood. By training the model on several chemical …
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Perturbation Modeling for Molecular Design of Protein Tyrosine Kinase Inhibitors using Unsupervised Machine Learning
… conduct transformations of small molecules to SRC kinase inhibitors using a combination of a generative learning technique called Variational Auto-Encoders and Unsupervised Machine Learning techniques. This study focuses specifically using the methods above to transform molecules from various …
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Rolle der Src-Kinasen in den Signaltransduktionswegen von Interleukin-6 und Erythropoetin
Wir zeigten in dieser Arbeit, dass Mitglieder der Src-Kinasen Familie durch IL-6 und Epo aktiviert werden und mit deren Rezeptoren, vor allem dem EpoR, assoziieren. Darüber hinaus scheint die Src-Kinase Lyn eine Rolle in der erythrozytären Differenzierung zu spielen.
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… to EGFR-targeted small molecule tyrosine kinase inhibitors (TKIs). Specifically, we have shown that EGFR localizes to discrete membrane microdomains (lipid rafts) in cell lines that are resistant to EGFR TKI-induced growth inhibition. Depletion of lipid rafts via cholesterol reduction …
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Untersuchungen zu Protein-Interaktionspartnern des HCN2 Schrittmacherkanals
… Außerdem wurde der Frage nachgegangen, ob die Src-Kinase mit mHCN2 interagiert.
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Novel Design Strategy for Potent and Selective CDPK1 Inhibitors for Cryptosporidiosis
Calcium – dependent protein kinase 1 (CDPK1) is a key enzyme functioning in cell motility of Cryptosporidium parvum (Cp) and C. hominis, the parasitic protozoa accountable for life-threatening diarrhea in young children and immunocompromised individuals worldwide. The unmet clinical need for the …
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Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
… eigener Vorarbei-ten war bekannt, dass IL-6 die Src-Kinasen Hck, Fyn und Lyn aktiviert. Ziel die-ser Arbeit war es, genauere Erkenntnisse über die genauen Mechanismen dieser Aktivierung zu gewinnen. Mittels Mutationsanalysen wurde eine „saure Domäne“ zwischen den Aminosäu-ren 771 und 811 von …
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FROM NUCLEUS TO MITOCHONDRIA: INSIGHTS INTO THE ROLE OF TERT IN THE PROGRESSION OF PAPILLARY THYROID CARCINOMA
… Moreover, we investigated the effect of PP2, a SRC kinase inhibitor, which is supposed to inhibit the pathway that allows for TERT nuclear export, on K1 cell proliferation. We found that TERT shuttled into the cytoplasm and in some cases to the mitochondria in response to OS increase either from …
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TIS21 inhibits cell migration and invasion
… correlated with downregulation of focal adhesion kinase (FAK) tyr576 and tyr925 residues phosphorylation. However, tyr397 which was autophosphorylation site was not influenced by TIS21 expression. c-Src phosphorylation which was upstream of FAK was not influenced by TIS21, however, c-Src kinase …
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Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
Protein phosphorylation, catalyzed by protein kinases, is the predominant post-translational modification made to proteins. This process is readily reversible, with protein phosphatases catalyzing removal of the installed phosphate groups. Together, protein kinases and phosphatases modulate the …
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A study of keratinocyte differentiation and adhesion in vitro
… an investigation of the role played by the Src-family of protein tyrosine kinases at calcium-induced cadherin-mediated adherens junctions. The ubiquitously expressed members of this family, c-Src, Fyn and c-Yes were localised to the cadherin-mediated adhesions formed in response to high …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… We studied two adhesion-associated proteins, Src and Pyk2, which may function as “STOP” mechanosomes. Src kinase is involved in a number of signaling pathways that respond to changes in external loads on bone. An inhibition of Src causes an increase in the expression of the anabolic bone gene …
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… activation led to the specific activation of SRC kinase. In addition, our results unveiled a role for the BTLA-associated Grb2-binding motif in T cell proliferation and IL-2 production following TCR engagement that was independent of the inhibitory function of ITIM/ITSM motifs.</p> <p>Overall, …
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Gender Differences In Cardiomyocyte Remodeling and Adhesion In Response to Chronic Elevations In Myocardial Stress
… in myocyte adhesion by TNF-α was reversed by the Src kinase inhibitor, PP2. These results indicate that the TNF-α reduced cardiomyocyte adhesion involves Src kinases. Taken together, we conclude that TNF-α modulates myocyte adhesion and possibly accounts for the gender difference in myocyte …
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Increased Microglial Reactivity Alters Morphine Analgesia
… function mediated by µ-receptor activation of Src kinase. Specifically, I identified tyrosine residues 382-384 on the P2X7R C-terminal domain as a critical site of phosphorylation and found that interfering with this site attenuated the development of tolerance in rats. I also show that the …
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