Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 350 for “"SRC"”.
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Src-Kinasen als Mediatoren Bcr-Abl-induzierter Leukämien
… sich hierbei um die Mitglieder der Familie der Src-Kinasen, die über einen komplexen Mechanismus, letztlich aber unabhängig von der Aktivität der Abl-Kinase, aktiviert werden (siehe Abschnitt 3.1 und 3.2). Tierexperimente zeigten, dass diese Kinasen zumindest im Rahmen der Bcr-Abl-positiven …
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Fully Soft-Switching Modulation Methods for SRC-Unfolding Inverter
Isolated inverters feature the freedom in voltage step-up/down, electrical safety, and modularity. Among them, pseudo-dc-link inverters have the advantage of high efficiency due to their single-stage structure. Traditionally, pseudo-dc-link inverters are based on pulse-width-modulated converters, …
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Benchmarking and analysis of the SRC-6E reconfigurable computing system
This thesis evaluates the usefulness of the SRC-6E reconfigurable computing system for a radar signal processing application and documents the process of creating and importing VHDL code to configure the user definable logic on the SRC-6E. A false-target radar-imaging algorithm was chosen and …
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Role of Src phosphorylation of FXR in bile acid regulation
… paired with bioinformatic tools identified Src as the kinase responsible for this post-translational modification. Feeding mice a diet supplemented with the primary bile acid cholic acid (CA) led to interaction between FXR and Src as well as phosphorylation of FXR. Further studies showed …
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The Src- and Abl- Dependent Regulation of Net1A In Breast Cancer
… Here we demonstrate that EGF stimulates Src- and Abl1-dependent phosphorylation of Net1A to promote its cytosolic localization. We find that Abl1 efficiently phosphorylates Net1A on Y373, and that phenylalanine substitution of Y373 prevents Net1A cytosolic localization. Aspartate …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
… signature.” The non-receptor tyrosine kinase Src is commonly upregulated in breast cancers, often in conjunction with overexpression of EGFR. Signaling from this pathway stimulates cell proliferation, migration, and invasion and frequently involves proteins that regulate the cytoskeleton. My …
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
<p>The vertebrate proto-oncogene, Src, is the prototype of a family of membrane-associated protein tyrosine kinases involved in cell signaling pathways that control cell growth, development, and differentiation. Activation of Src by mutation or overexpression has been implicated in a range of …
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Rolle der Src-Kinasen in den Signaltransduktionswegen von Interleukin-6 und Erythropoetin
Wir zeigten in dieser Arbeit, dass Mitglieder der Src-Kinasen Familie durch IL-6 und Epo aktiviert werden und mit deren Rezeptoren, vor allem dem EpoR, assoziieren. Darüber hinaus scheint die Src-Kinase Lyn eine Rolle in der erythrozytären Differenzierung zu spielen.
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… signal transduction pathways required for EMT. Src kinase is a non-receptor tyrosine kinase well characterized to function in growth factor as well as ECM signal transduction, but its role in epicardial cell biology is unclear. Our hypothesis is that Src kinase is a critical regulator of TGFβ …
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Using sEMG to investigate muscle activation during a graded exercise test while sustaining SRC
Sport-related concussions (SRCs) are common injuries among athletes, often resulting in cognitive, emotional, and physical impairments that can extend beyond the acute phase of injury. While SRCs are known to disrupt neuromuscular function and increase the risk of lower extremity (LE) injuries, …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… toxicity of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in cell migration, metastasis, proliferation, survival, and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, …
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Design, synthesis, and thermodynamic evaluation of peptidomimetic ligands binding to the Src SH2 domain
… pYEEI-derived peptidomimetic ligands to the Src SH2 domain were evaluated to investigate the effects of structural changes on protein-ligand binding energetics. The effect of preorganizing the pYEEI ligand into its binding conformation was analyzed by substituting the isoleucine residue with …
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<i>Ixodes Scapularis</i> SRC Kinase Is Required for Rickettsial Pathogen Survival in Ticks
… in order to increase its survival in ticks. Src kinase, a non-receptor protein-tyrosine kinase, is a major player in cell signaling. Src kinase has an impact on the spread and survival of <em>A</em>. <em>phagocytophilum</em> in ticks. Studies on Src kinase in <em>I. scapularis</em> show that …
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Implication de la c-SRC kinase dans le métabolisme et la morphologie des mitochondries
… ont montré que dans la mitochondrie, la c-Src kinase (tyrosine-kinase) cible des protéines mitochondriales et régule leurs fonctions.
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The role of SRC family kinases in the development and progression of prostate cancer
… provides an attractive targeting mechanism. Src family of non-receptor tyrosine kinases (SFK) represent proteins involved in the development of various solid malignancies, including prostate cancer. These proteins are often found on the cross-roads of intracellular pathways, integrating …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
… and interaction with the associated coactivator SRC-3 (Steroid Receptor Coactivator-3), a member of p160 family (28) primary coactivators. ERalpha is a steroid-dependent transcriptional factor (16) that belongs to the NRs superfamily (2,3) and, in response to the hormone 17-ß estradiol (E2), …
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The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… IGF-1, IL-1, LPS, and RANKL. We identify Src tyrosine kinase as a direct kinase for TRAF6 and a mediator of TRAF6 Y473 phosphorylation. Notably, we find that Src or Traf6 deficiency impairs IKK, Akt, and JNK activation, which can be rescued by phosphomimetic TRAF6, but not by …
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Rapid Rac GTP-ASE activation in live cells by mechanical stress is independent of Src
… that PDGF-induced Rac activation depends on Src activity. There was no stress-induced Rac activation when a mutant form of the Rac biosensor (RacN17) was transfected or when the magnetic bead was coated with transferrin or with poly-L-lysine. Surprisingly, pre-treatment of the cells with …
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