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Showing 1 to 14 of 14 for “"SR141716A"”.
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The human cannabinoid CB(1) receptor stably expressed in Chinese hamster ovary cells provides a model system to predict the pharmacological effects of cannabinoids in man
… receptors. Saturation binding studies using [³H]SR141716A and [³H]CP55,940 determined that this system expresses the human cannabinoid CB₁ receptor at approximately 1.8 pmoles of receptor/mg protein and that this expression system is able to differentially bind agonists (CP55,940) and antagonists …
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Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone
… change in the binding affinity of CP55,940 or SR141716A. Computational results indicate that the D2.63176-K373 ionic interaction strongly influences the conformation(s) of the EC-3 loop, providing a structure-based rationale for the importance of the EC-3 loop to signal transduction in CB1. …
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Relationship Between CB1 and S1P Receptors in the Central Nervous System
… cord. The effect of cannabinoid antagonists, SR141716A (CB1) and SR144528 (CB2) on S1P-and WIN-stimulated [35S]GTPγS binding were also examined in mouse spinal cord homogenates. These results showed that there was no significant difference between S1P-stimulated [35S]GTPγS binding in the …
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The Influence of Sustained CB1 Blockade During Adolescence on Breakpoints in a Progressive-ratio Paradigm
… male Long-Evans rats were treated with SR141716A, a cannabinoid antagonist, throughout adolescence and allowed unrestricted access to food. Control groups were treated with vehicle during the same developmental period and allowed either unrestricted access to food or were pair-fed with a …
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Pharmacological modulation of learning and memory in mice and zebrafish: Implications for Alzheimer’s disease animal models
… the potential of a CB1 receptor antagonist (SR141716A) as a novel cognitive enhancer in mice models; (2) Assessing the potential of zebrafish as an alternative in vivo model for the high-through put assessment of learning and memory. The involvement of cannabinoid CB1 (CB1) receptors in …
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… i.p) or the CB1 antagonist/inverse agonist SR141716A (1 mg/kg, i.p) did no antagonize the antidepressant-like effect induced by classical antidepressant drugs. In contrast the antidepressant-like affects of clofibrate were reverted by the acute administration of specific PPARα antagonist …
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Wirkung von Cannabinoiden auf die Neurotransmission im Corpus striatum und in der Substantia nigra pars reticulata
… durch den CB1-Rezeptor-spezifischen Antagonisten SR141716A: dies beweist die Beteiligung von CB1-Rezeptoren. Die Beobachtung, dass muscimolinduzierte Ströme durch WIN55212-2 nicht beeinflusst wurden, spricht dafür, dass das Cannabinoid die GABAerge neuronale Übertragung mit einem präsynaptischen …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… the prototypical cannabinoid antagonist <strong>SR141716A</strong> (Rimonabant), the triazole ester <strong>31a</strong> did not exhibit increased activity in locomotor activity studies, thus indicating the potential for a neutral antagonist profile.</p>
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Eficacia antiparkinsoniana de ligandos cannabinoides del receptor CB1 en un modelo animal de la enfermedad de Parkinson
… 2 antagonistas cannabinoides del receptor CB1, SR141716A y AM251, y su interacción con receptores dopaminérgicos a nivel estriatal, y valorar la eficacia antiparkinsoniana de un agonista cannabinoide CB1, el AM404, junto a su interacción con receptores dopaminérgicos y serotoninérgicos en el …
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Modificazioni neuronali nella via abenulo-mesencefalica durante l’astinenza da Δ9-tetraidrocannabinolo
… Administration of the cannabinoid antagonist SR141716A (5 mg/kg, i.p.) precipitated an intense behavioral withdrawal syndrome, whereas abrupt Δ9-THC suspension caused only milder signs of abstinence. Electrophysiological experiments confirmed that Δ9-THC withdrawal produced a marked decrease …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… were pre-treated with the CB1 rceptor antagonist SR141716A (SR). SR partially blocked METH-induced nNOS-overexpression but failed to revert the decreasing effect of Δ9-THC on METH-induced GFAP-immunostaining. These results indicate that Δ9-THC reduces METH-induced brain damage by CB1-dependent and …
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Characterization of Rimonabant effects on G protein activity
… and potent CB1 antagonist Rimonabant (also known SR141716A, SR) at high micromolar concentrations behaves as an inverse agonist, i.e. decreases [35S]GTPγS binding in rodent and human cerebral cortex and in Chinese hamster ovary (CHO) cells transfected with CB1 receptors (Rinaldi-Carmona, 1994). …