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Showing 1 to 8 of 8 for “"SR141716"”.
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EFFECTS OF ENHANCING ANANDAMIDE LEVELS ON HIPPOCAMPAL NEUROPHYSIOLOGY AND SHORT-TERM MEMORY PROCESSING IN RATS
… with the cannabinoid receptor antagonist, SR141716 (Rimonanbant), was able to block some of these effects of the R-methanandamide, VDM11 and URB597. In addition, R-methanandamide but not, VDM11 and URB597, caused a significant decrease in performance of the DNMS task and reduction during …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… in the prototypical antagonist/inverse agonist SR141716 (Rimonabant) that was presumed to interact with a unique region in the CB1 receptors. Based on our preliminary results we identified a novel series of 1,2,3-triazole ester and keto derivatives as lead compounds for biological evaluation. …
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Präsynaptische Modulationen der Neurotransmission im Neokortexgewebe : (1) der CB1-Rezeptor beim Menschen, (2) die spannungsabhängigen Ca2+-Kanäle beim Menschen, (3) der Kationenstrom Ih der Ratte
… Für künftige (prä-)klinische Studien (zu SR141716 als Appetitzügler beispielsweise) sind diese Funde von Bedeutung, da die unterschiedlichen Verhältnisse des Endocannabinoid-Systems, die in dieser Arbeit beschrieben sind, zu unterschiedlichen biologischen Antworten in der Maus im Vergleich …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… abolished by the CB1 antagonists AM251 and SR141716. Unlike theta burst stimulation (TBS) induced LTP, 10 Hz LTP does not require NMDA receptor activation. However, it is prevented when both NMDA and group1 mGluR receptors are blocked. The 10 Hz LTP is also independent of GABAergic synaptic …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… abolished by the CB1 antagonists AM251 and SR141716. Unlike theta burst stimulation (TBS) induced LTP, 10 Hz LTP does not require NMDA receptor activation. However, it is prevented when both NMDA and group1 mGluR receptors are blocked. The 10 Hz LTP is also independent of GABAergic synaptic …
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Modulation der neokortikalen Neurotransmission durch exogene und endogene Cannabinoide unter Berücksichtigung möglicher Speziesunterschiede zwischen Mensch und Tier
… war. Zudem kam es nach CB1-R Blockade durch SR141716 (CB1-R Antagonist) nur im Menschen zu einer erhöhten [³H]-ACh Freisetzung. Dies ließ auf einen hohen hemmenden Einfluss endogener CB1-R Agonisten wie Anandamid (AEA) auf die cholinerge Transmission im humanen Neokortex schließen. Das Ausmaß …
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Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models of Pain: Is Less More?
An ultra-low dose of a drug is approximately 1000-fold lower than the dose range traditionally used to induce a therapeutic effect. The purpose of the present thesis was to broaden the knowledge of the ultra-low dose effect, that was previously identified in the opioid receptor system, by looking …
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Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
Genetic deletion or pharmacological blockade of the CB1 receptor has been reported to impair extinction learning in aversive conditioning (i.e., conditioned fear and Morris water maze) paradigms, but not in operant procedures in which food reinforcement is earned. It is difficult to discern whether …