Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"SR-BI"”.
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Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice
… the buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout (dKO) mice are a novel mouse model of human CHD, exhibiting spontaneous coronary occlusive atherosclerosis, myocardial infarction, cardiac dysfunction and premature death. This model represents a unique system in which to …
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CHOLESTEROL ABSORPTION AND TRANSINTESTINAL CHOLESTEROL EFFLUX (TICE) RATES ARE UNALTERED IN MICE OVEREXPRESSING INTESTINAL SR-BI.
… transport (RCT) does not rely solely on biliary secretion (37), but also involves the direct excretion of cholesterol by the proximal small intestine through a process known as trans-intestinal cholesterol efflux (TICE). There is almost no information in literature regarding molecular …
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Effekte des oxidativen Stresses auf die Expression der Scavenger-Rezeptoren CD36 und SR-BI und des Transkriptionsfaktors PPARγ in Makrophagen
… der atherogenen Scavenger-Rezeptoren CD36, SR-BI, des Transkriptionsfaktors PPARγ und pro-inflammatorischer Zytokine zu untersuchen. Die durchgeführten Untersuchungen beruhen auf der Annahme, dass modifizierte LDL durch Induktion der genannten Scavenger-Rezeptoren und nachfolgende …
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Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1
… containing cytoplasmic adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a post-transcriptional, tissue-specific decrease in SR-BI protein level and an increase in total plasma …
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The role of scavenger receptor B-I in hepatitis C virus attachment and entry.
… entry factors: CD81, Scavenger Receptor B-I (SR-BI) and Claudin-1. SR-BI is a receptor for high density lipoprotein (HDL), it is predominantly expressed in the liver and steroidogenic tissue. HCV is believed to interact with SR-BI via the viral envelope protein E2, interestingly the SR-BI …
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Cholesterol and egg activation
The high-density lipoprotein (HDL) receptor SR-BI controls the structure and fate of plasma HDL. The SR-BI knockout (KO) females are infertile, apparently due to their abnormal, cholesterol-enriched HDL particles. In this thesis, my colleagues and I examined the growth and meiotic progression of …
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Using chemical biology as a tool to probe the mechanism of the HDL receptor
… receptor, scavenger receptor, class B, type I (SR-BI), is a cell surface glycoprotein that controls HDL structure and metabolism by mediating cellular selective uptake of lipids from HDL. The mechanism underlying SR-BI-mediated lipid transfer involves a two-step process (binding followed by …
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Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… provides vascular protection are unclear. The disruption of endothelial monolayer integrity is an important contributing factor in multiple vascular disorders, and vascular lesion severity is tempered by enhanced endothelial repair. In these studies we show that HDL stimulates endothelial cell …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
… and requires CD81, Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be efficiently cultured in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context extremely difficult. …
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The Structural Basis of Flaviviridae Interaction with Antibodies and Receptors
… and membrane fusion. The assignment of biological functions to specific structural elements of these E proteins has proven crucial to the understanding of viral entry into host cells. Clearance is dependent upon the presence of neutralizing antibodies that are able to disrupt several …
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Mining Genomic Variants And Causal Pathways Linking Hdl And Triglycerides To Coronary Disease
Blood lipids are important biomarkers of risk of coronary heart disease (CHD), the leading cause of death in the world. Myriad data support a causal role of low-density lipoprotein cholesterol (LDL-C) in increasing risk of CHD. Long-standing epidemiology suggests that high-density lipoprotein …
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Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
… which was also identified as a transdominant inhibitor of BVDV entry in a screen of a random fragment BVDV cDNA library. The inhibitory region was further mapped to the E2 ectodomain and the block to entry was shown to occur downstream of CD46 receptor expression and BVDV binding, suggesting …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
… by targeting tumors through scavenger receptor BI (SR-BI), that is overexpressed in different tumor types, including PCa. Aim. Previous in vitro and in vivo studies have shown that HDL can inhibit PCa tumour growth by reducing intracellular cholesterol content and oxidative stress, inflammation …