Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"SR proteins"”.
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SR proteins in microRNA/mRNA biogenesis
<p>SR proteins are a family of splicing factors involved in the regulation of both constitutive and alternative splicing of pre-mRNAs. Despite years of studies, several big questions still remain: how the expression levels of SR proteins are regulated; what are the underlying mechanisms responsible …
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Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins
… in part, to reduced translation of serine-rich proteins in serine-starved conditions, including the serine/arginine-rich splicing factor (SRSF) proteins that are known regulators of mRNA splicing. Indeed, we have found that translation of the SRSF family member SRSF6 is reduced upon serine …
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Can changes in SR protein acetylation affect alternative splicing?
… tissue and developmental-specific fashion. The misreguation of alternative splicing has been documented in many human diseases. The regulation of alternative splicing involves a complex network of proteins and RNA. Serine-arginine repeat (SR) proteins are a known family of regulatory proteins that …
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Characterisation of Tau splicing factors in Alzheimer’s disease
… factors including serine and arginine (SR) rich proteins that either repress or promote E10 inclusion and CELF proteins are of particular interest. The brain selective CELF3 promotes tau E10 inclusion in vitro by binding to an intronic element in tau pre-mRNA. The levels of expression of …
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Identification of the RNA Cis-Elements that Interact with SRp30a to Regulate the Alternative Splicing of Caspase 9 Pre-mRNA
… splicing of caspase 9 and the phospho-status of SR proteins, a conserved family of splicing factors, are regulated by chemotherapy and de novo ceramide via the action of protein phosphatase-1 (PP1). Two RNA splice variants are derived from the caspase 9 gene, pro-apoptotic caspase 9a and …
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Characterization of the mechanisms behind the alternative splicing of the mutually exclusive exons 18N and 18A in the sodium channel gene SCN8A and mutually exclusive exons 5N and 5A in the soldium channel gene SCN9A
… the presence in the cell types of several hnRNPs proteins that function through an exonic splicing silencer (ESS) found in this exon together with the absence of neuron specific Fox-I protein. In neuronal cells the absence of these hnRNPs together with the presence of neuron specific Fox-l cause …
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Junctional Sarcoplasmic Reticulum Protein Processing And Trafficking In Cardiac Tissue And Primary Cultured Cardiomyocytes
<p>Junctional SR is an important and unique ER subdomain in the adult myocyte that releases Ca2+ through the actions of an exclusive set of resident proteins. Cardiac calsequestrin (CSQ2) undergoes two co-translational modifications: N-linked glycosylation on 316Asn, and phosphorylation by protein …
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The Effect of Low Temperature on Alternative Splicing in Barley
… factors in Arabidopsis, such as STA1 and SRL1 have been shown to lead to both changes in AS and changes in cold-sensitivity/tolerance, suggesting an important the role for AS in regulating the cold-response. Less is known about the effect of cold on AS in barley or how AS impacts the …
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Design, synthesis, and analysis of conjugated activators for modulation of alternative splicing
… from a single gene. Splicing is controlled by SR proteins, factors which bind to exonic splicing enhancers (ESEs) through RNA binding domains and recruit the splicosome via protein-protein interactions mediated by their RS domains, protein domains rich in highly charged arginine-serine …
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Regulation of Human Telomerase Alternative Splicing
… reporter for a selected 528 RNA-binding proteins/splicing factors siRNA screen. Our initial validation focused on 45 factors with enzymatic activity and resulted in CDC-Like Kinase 1 (CLK-1) as a potential hTERT splicing modulator. Knock-down of CLK-1 altered hTERT splicing, resulting in …
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Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing
… splicing, where one gene gives rise to multiple proteins. Alternatively spliced gene products, although crucial for normal physiology, are also linked to an increasing number of pathologies. Consequently, a growing focus is currently being placed on elucidating the extrinsic cues and ensuing …
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Second-step splicing factors and heavy metal stress management in Arabidopsis thaliana
… contribute to their interactions with other proteins. For example, residues important for protein-protein interaction in ScPRP17 are unique on AtPRP17-2. Basic surface residues on ScPRP18 that contribute to interaction with ScSLU7 are in slightly different locations on both AtPRP18A and …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
… which encode highly immunogenic viral structural proteins are only expressed in the suprabasal layers. HPV-16 infections are normally cleared within 18-24 months, but HPV-16 can establish persistent infections that progress to cancer. Such HPV-infected cancer cells express early HPV-16 genes but …
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RNA modifications and processing in cell homeostasis and in response to oxidative stress
… NSun2 and the alternative splicing factor Srsf2 are linked to neurological disorders and cancer in humans, respectively. NSun2 methylates cytosine-5 in most tRNAs and, to a lesser extent, other ncRNAs and mRNAs. Srsf2 is a critical component of the spliceosome and interacts with abundant …