Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"SR Ca2+-leak"”.
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
… emerging evidence suggests that intracellular Ca2+ mishandling during I/R plays a key role in cell death. Junctophilin-2 (JPH2) is a junctional membrane-binding structural protein. It mechanically maintains the fixed distance between the T-tubule and the sarcoplasmic reticulum (SR), thus …
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Die Bedeutung der subzellulären CaMKIIδ-Überexpression auf den intrazellulären Ca2+-Stoffwechsel in Herzmuskelzellen
Die Ca2+/Calmodulin-abhängige Proteinkinase II (CaMKII) ist eine multifunktionelle Serin-/Threoninkinase. Sie ist multimerisch aus 6 bis 12 Monomeren aufgebaut. Die δ-Isoform ist die dominante Isoform im Herzen und existiert in zwei Splice-Varianten, der zytosolischen CaMKIIδC und der nukleären …
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Structural and contractile alterations in skeletal muscles from the genetically obese (ob/ob) mouse: impairment or adaptation?
… alterations in the contractile apparatus and/or SR function was explored using a single fibre approach. In these experiments, the following parameters were probed in mechanically skinned type IIB fibres (the predominant fibre type in both muscle groups) from EDL muscles of ob/ob and lean mice: …