Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"SQSTM1"”.
-
The role of DAXX in the selective autophagy receptor SQSTM1/p62 phase condensation
… which is dependent on cargo receptors. SQSTM1/p62 (‘p62’ hereafter) is one of the best characterised receptors mediating the autophagic degradation of misfolded proteins, and its body formation is essential for its cargo recognition and clearance. Mounting evidence has revealed that …
-
Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
… domain containing autophagy adaptors (SQSTM1, VCP, OPTN) and prion-like domain containing stress granule proteins (HNRNPA2B1, HNRNPA1, MATR3, TIA1). Previous studies identified that a non-pathogenic variant of the non-classical MSP protein, TIA1 N357S , can act as a phenotype modifier …
-
Corneal fibrosis therapies and investigations in the canine corna in vitro
… of autophagy-related genes (LC3, Beclin1, Sqstm1/p62, and Lamp1) in healthy and injured corneal stromal fibroblasts. Methods: Primary cultures of corneal stromal fibroblasts (CSFs) were generated from healthy donor canine corneas and grown in minimum essential medium (MEM) containing 10 …
-
SHORT-CHAIN FATTY ACIDS INDUCED AUTOPHAGY SERVES AS AN ADAPTIVE STRATEGY FOR RETARDING MITOCHONDRIA-MEDIATED APOPTOTIC CELL DEATH
… vesicular organelle development and reduced p62/SQSTM1 expression. Propionate-induced autophagy was associated with decreased mTOR activity and enhanced AMP kinase activity. The elevated AMPKα phosphorylation was associated with cellular ATP depletion and overproduction of reactive oxygen species …
-
Exosome-Mediated Protection Against Oxidative Stress: A Connection Between NRF2 And Exosomes
… generally enriched for cytoprotective protein SQSTM1. However, although NRF2-induced exosomes were cytoprotective in some assays, this response was not robust enough for me to conclude that NRF2-induced exosomes can protect naïve cells from oxidative stress. Thus, exosomes provide a potential …
-
A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
… of hepatic autophagy gene including LC3b, P62/SQSTM1, Beclin1, Atg3, Atg7, Atg5, and Atg10 was increased significantly only in the female offspring by gestational low-protein diet. The induction of gene expression was consistent with the activated eIF2a/ATF4 pathway in female offspring. …
-
Overcoming chemoresistance in osteosarcoma: the role of autophagy in cell death or survival following chemotherapy
… conversion) that correlated with reduced p62/SQSTM1 expression, analysed by Western Blot. RT-PCR results confirmed this pattern. Combination of chloroquine (CQ) with chemotherapy had a significant effect on OS cell proliferation and cell death rate. However, the results of CQ combination could …
-
MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… or soluble proteins (such as CALCOCO1 and SQSTM1), that bind to cytosolic Atg8-family proteins via the LC3-Interacting Region (LIR) mediating the delivery of specific ER subdomains to lysosomes for degradation. Although the role of the ER-phagy in the regulation of ER size and cellular …
-
The role of autophagy in canine osteosarcoma
… markers of autophagy (MAP1LC3, ATG5, ATG7 and SQSTM1), emphasizing the importance of autophagy in the induction of the metastatic process. Chemoresistance is a major challenge in the treatment of both human and canine patients with metastatic OS. Our overall data suggest that autophagy indeed …
-
Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… transcriptional levels of p62 (sequestosome 1, SQSTM1), α-synuclein (SNCA), and transglutaminase-2 (TGM2). Strikingly, pharmacological cathepsin B/L inhibition using CA074Me mimicked UVA-induced accumulation of lipofuscin and autophagic-lysosomal proteins (Lamp-1, LC3-II, and p62), as well as …
-
CROSS-DISEASE ANALYSIS OF MOLECULAR AND CELLULAR MECHANISMS IN KIF5A-ASSOCIATED NEURODEGENERATIVE DISORDERS
… KIF5A mutant also formed sequestosome 1/p62 (SQSTM1/p62)-positive detergent-insoluble inclusions sequestering WT KIF5A, indicating a gain of toxic function. Cycloheximide chase assays in SH-SY5Y neuroblastoma cells demonstrated a shorter half-life for the SPG10-related R17Q and ALS-related …
-
The Role of Autophagy In The Sensitivity of Osteosarcoma Cells to Gemcitabine Treatment
… Beclin expression and a decrease in p62/SQSTM1 protein expression. Formation of autophagic vacuoles was also demonstrated using electron microscopy. These results confirm that autophagy was induced following GCB treatment. Furthermore, western blot analysis and kinase array assays …
-
Características histopatológias y biomarcadores del cáncer colorrectal metastásico asociados al desarrollo de enfermedad trombombólica venosa
… con los siguientes genes: MAP3K7 (n=32), SQSTM1 (n=21), CAP1 (n=7), LMXB1 (n=7), AP3D1 (n=6), SPRY1 (n=5), FOSL2 (n=4), GOS3 (n=3), HYOU1 (n=2), RAD54B (n=2), RRAGB (n=2), GSDMA (n=1) e ITIH3 (n=1). En 10 de las vías diferencialmente expresadas, estaban implicados más de 1 transcrito. …
-
Defining novel targets and functions of the protein kinase DYRK2
Protein post-translational modifications (PTMs) are an essential and conserved mechanism that allows eukaryotic cells to coordinate rapid responses to changing environmental conditions. Protein kinases, comprising a large eukaryotic superfamily of ~518 proteins, catalyse protein phosphorylation. …