Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"SPRTN"”.
-
Investigation of Genomic Instability Induced By G-Quadruplexes In The Absence of Functional to poisomerase 1 In Yeast
… mutants bind G4s <em>in vitro</em> and that the SPRTN homolog Wss1 involved in DNA/protein crosslink resolution partly suppresses G4-induced recombination in yeast cells expressing Top1 cleavage-defective mutants. Collectively, these data suggest that Top1 cleavage-defective mutants induce …
-
DNA-Protein Cross-links: Formation, Repair, and Inhibition of DNA replication
… livers, and kidneys of Spartan hypomorphic (SPRTNf/-) mice compared to wild type (SPRTN+/+), providing evidence that Spartan plays a direct role in the repair of ROS-induced DPCs.
-
Development of The Ark Assay For Quantitating Dna- Protein Crosslink Accumulation and Fanconi Anemia Pathway Involvement In The Repair Process
<p>DNA-protein crosslinks (DPCs) are a common DNA lesion naturally arising in cells, wherein protein becomes covalently and irreversibly bound to the DNA. Given their excessive size, these adducts present a significant challenge to replication and transcription, thus requiring timely and efficient …