Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 217 for “"SPR"”.
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Investigating the Structure of the Papain-Inhibitor Complex using SPR and NMR
… kinetics of papain and ICP were determined using SPR. 13C-methyl peak perturbations due to PRE were observed when papain was bound to spin-labeled E102C-ICP and K27C-ICP. Intermolecular distances were predicted using modeling software and a working model of the complex was created. Data from …
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The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR
… an actinomycete, Streptomyces polyantibioticus SPRT, was isolated from soil collected from the banks of the Umgeni River, KwaZulu-Natal Province, South Africa. It exhibited antibiosis against M. tuberculosis H37RvT, prompting interest in its antibiotic production. An antibiotic produced by S. …
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Design and investigation of a novel 𝝿-configuration spr sensor for multi-parameter biosensing applications.
… biosensors based on Surface Plasmon Resonance (SPR) principles have emerged as a viable alternative, allowing for real-time, label-free molecular interaction monitoring. However, widespread adoption of conventional SPR platforms has been hampered by their susceptibility to environmental drift, …
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Targeting an E3 ubiquitin ligase Siah1 and a cysteine protease SENP1 using SPR and DSF-based fragment screening
… from fragment screening against Siah1 using SPR and DSF are reported in chapter 3. The chapter also presents the structure of Siah1 refined to 1.95 Å that displays new parts of the structure, previously missing due to the absence of reliable electron density. Chapter 4 contains results from …
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The Development of an Aptamer-based Surface Plasmon Resonance (SPR) Sensor for the Real-time Detection of Glycated Protein
… an aptamer-based surface plasmon resonance (SPR) sensors for the real-time detection of glycated blood proteins (i.e., GA) has been studied. For the purpose of establishment, the well documented thrombin binding aptamers were immobilized onto a gold sensing surface using a two-step amine …
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Preparation of Heparin Surface for Quantification of Fibroblast Growth Factor-2 (FGF-2) Binding Using Surface Plasmon Resonance (SPR)
… Reichert Inc, SR7000, surface plasmon resonance (SPR) instrument. The heparin was attached via streptavidin-biotin linkage where the streptavidin was covalently coupled to the mSAM and biotinylated heparin bound to it. These chips were then used to quantify the interactions of fibroblast growth …
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Using multiple layers and surface roughness control for improving the sensitivity of SRP sensors
Surface plasmon resonance (SPR) sensors have been developed quickly in the past twenty years in biosensing. However, the sensitivity of them restricts them from small molecular detection. This thesis focuses on the sensor chips of the SPR sensors and presents two potential methods to improve the …
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Output performance, institutions and structural policy reforms for transition economies
… group of variables is structural policy reforms (SPR), often known as liberalization policies. This dissertation’s theoretical and empirical framework explicitly account for the endogeneity between output performance variables, the measures of institutional development and SPR. Several empirical …
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Finite element analysis of self-pierce riveting in magnesium alloys sheets
… alloys. Therefore, self-pierce riveting (SPR) has been presented as an attractive joining technique for these lightweight metals. However, SPR must be performed at elevated temperatures because of the low ductility of magnesium alloys at room temperature. Even though the SPR joining …
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Real Time Biological Threat Agent Detection with a Surface Plasmon Resonance Equipped Unmanned Aerial Vehicle
… a feasible task. A Surface Plasmon Resonance (SPR) biosensor was integrated for the first time into a small UAV platform, allowing the UAV platform to collect and then quantify the concentration of an aerosolized biological agent in real-time. A sensor operator ran the SPR unit through a …
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Evaluation and Clinical Implementation of a Dual-Energy CT Stopping-Power Ratio Mapping Technique for Proton-Therapy Treatment Planning
… practice for predicting stopping-power ratio (SPR) consists of a stoichiometric calibrationtechnique based on single-energy CT (SECT) for direct estimation of patient-specific SPR distribution from vendor-reconstructed Hounsfield Unit (HU) images. Unfortunately, this approach fails to …
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Performance of short piled raft foundation system on peat soil under static load
… to explore a proposed Short Piled Raft (SPR) foundation system, which is a combination of a pile foundation and raft foundation, with a pile length short enough. The objectives of this research were to optimize pile spacing of SPR foundation system related to its stability, especially …
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The Polycomb Complex 2 contributes to developmental delay when histone methylation is inappropriately inherited
… H3K4me is removed by the H3K4 demethylase, SPR-5, and H3K9me is subsequently added by the histone methyltransferase, MET-2. Recently, it was demonstrated that SPR- 5 and MET-2 maternal reprogramming antagonizes the H3K36 methyltransferase, MES-4, which maintains a transcriptional memory of a …
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Investigating the ability to use the CT scan projection radiograph to monitor adolescent idiopathic scoliosis
… the use of scan projection radiograph (SPR) in computed tomography (CT) to assess AIS by quantifying radiation dose from the SPR acquisitions and comparing it to those of digital radiography (DR) and a dedicated scoliosis imaging system (EOS) and by evaluating the accuracy of Cobb angle …
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Optimizing Barnes-Hut simulations for many-core super computers using the scalable parallel runtime
… compute nodes. The Scalable Parallel Runtime (SPR) is a project being developed at Sandia National Laboratories which attempts to address the challenge of efficiently utilizing the power of these new many-core systems. SPR is a combination of the Qthreads Library, Portals, and MPI. In this …
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Analysis and suppression of mutant sel-12 in Caenorhabditis elegans
… the sel-12 Egl defect. In several screens four spr genes (suppressor of presenilin) were identified, which are able to suppress both sel-12 defects in the egg-laying system. The spr genes are not able to influence LIN-12/Notch signaling directly but require the activity of the second C. elegans …
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Particle-modified Surface Plasmon Resonance Biosensor
Surface plasmon resonance (SPR) biosensors have attracted great attention in scientific research in the past three decades. Extensive studies on the immobilisation of biorecognition elements have been conducted in pursuit of higher sensitivity, but trialled formats have focussed on a thin layer …
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Development of plasmonic sensor using gold nanobipyramids for detection of glyphosate based pesticide
… to transverse surface plasmon resonance (t-SPR) and at wavelength around 720 and 780 nm, corresponding to longitudinal surface plasmon resonance (l-SPR). In sensing study, the changes in the peak position and intensity for both t-SPR and l-SPR, respectively, in de-ionized water (DIW) as …
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A comparison of sequential probability ratio and generalized attributes acceptance sampling plans
… sampling plan are shown to be better than Wald's SPR in a number of instances for representative operating characteristics. However, strictly in terms of ASN Wald's SPR is shown to be better. A computer program is devised which gives a good approximation of the variance of the estimator used for …
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Detection of Progesterone in Cow’s Milk for the Prediction of Reproductive Performance
… were determined by surface plasmon resonance (SPR) inhibition assays. Initially, low binding was observed, and thought to arise due to the conjugation of mAb to the relatively large magnetic beads causing steric hindrance of the binding between conjugated mAb and P4 immobilized on the SPR …
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