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Showing 1 to 7 of 7 for “"SPO11"”.
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ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… meiosis, ATM is known to negatively regulate SPO11-generated DNA double-strand breaks (DSBs). In mice, complete loss of ATM causes spermatocyte apoptosis during mid-prophase I, likely due to unrepaired DSBs. However, the effects of modulating ATM signaling are not understood. Reducing DSBs by …
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Genetic strategies to manipulate meiotic recombination in Arabidopsis thaliana
… targeted to specific sites. This project used a spo11-1 mutant, which is unable to produce the endogenous meiotic DNA DSBs that normally mature into crossovers. Instead, TALFokI nucleases (TALENs) were expressed from meiotic promoters in order to generate exogenous DSBs at sites determined by the …
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Investigating the control of pairing and crossover formation in meiosis of Arabidopsis thaliana
… strand breaks (DSBs), formed by the protein SPO11-1. In Arabidopsis, ~10% of DSBs are repaired as crossovers, which are reciprocal exchanges of DNA between homologues. These physical connections ensure the correct segregation of chromosomes and generate genetic diversity. The remainder are …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… expressed in cancer. Here I found that the CTAs SPO11, GAGE and HORMAD1 play critical roles in cell survival, modulating response to DNA damaging agents, and DNA replication stress mitigation respectively. More specifically, we find HORMAD1 is critical for protecting stalled DNA replication forks …
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A forward genetic screen to identify factors that control meiotic recombination in Arabidopsis thaliana
… been identified in model systems. For example, SPO11 mediates generation of meiotic DNA double-strand breaks (DSBs) across all eukaryotes, which may be repaired as crossovers. However, downstream regulators of recombination remain to be identified, including those with species-specific roles. To …
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Sexual Reproduction and Signal Transduction in the Candida Species Complex
… in mating and meiosis, we use meiotic mapping, SPO11 mutant analysis, and comparative genome hybridization to demonstrate that these species are indeed meiotic, but that the meiosis that occurs is occasional unfaithful generating aneuploid and diploid progeny. </p><p>In the second and third …
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Genómica y transcriptómica comparativa de Trypanosoma Cruzi
… con meiosis y recombinación homologa SPO11 y RAD51. Los resultados obtenidos abren una ventana de conocimiento para el análisis de diferentes procesos fundamentales en el ciclo de vida de Trypanosoma cruzi¸ e incluso algunos que no habían sido previamente descritos, que podrían aportar …