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Showing 1 to 1 of 1 for “"SPLINT Labelling"”.
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The ubiquitin coat of cytosol-invading bacteria
… by host E3 ligases. In this work, I developed SPLINT Labelling, a novel tool to artificially induce ubiquitylation of S. flexneri by enforcing the recruitment of a Salmonella-targeting E3 ligase to the surface of Shigella. I demonstrate that SPLINT Labelling with LUBAC induces a M1-linked …