Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"SPIONs"”.
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Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis
… superparamagnetic iron oxide nanoparticles (SPIONs), capable of delivering antitubercular agents directly to the site of infection while providing T2-weighted magnetic resonance imaging (MRI) contrast for diagnostic tracking.SPIONs were synthesized via the chemical co-precipitation method and …
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Mycobacterium tuberculosis metallomics
… Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised via co-precipitation of ferric chloride and ferric sulphate. The SPIONs were subsequently surface modified with secondary metals (Ag, Au, Cu, Ni) to generate bimetallic systems (Ag@SPIONs, Au@SPIONs, Cu@SPIONs, Ni@SPIONs) or …
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Purification of human dna for dna profiling from body fluid contaminated soil using superparamagnetic iron oxide nanoparticles (spions).
… superparamagnetic iron oxide nanoparticles (SPIONs) generated in-house. Extraction success and level of purity of the human DNA extracted using these methods were assessed by quantifying the amount of DNA recovered using a Nanodrop 2000 and the amount of humic acid recovered using UV-Vis …
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Synthesis and development of hydrophilic iron oxide nanoparticles for biomedical applications
… superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and biocompatible. …
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EXPANDING APPLICATIONS OF IRON OXIDE NANOPARTICLES BY SURFACE FUCNTIONALIZATION: FROM MAGNETIC RESONANCE IMAGING TO NANO-CATALYSIS
… of superparamagnetic iron oxide nanoparticles (SPIONs) in MR imaging and nanocatalysis via surface functionalization. A dopamine-based surface-functionalization strategy was established. The Simanek dendrons (G1 to G3), oligonucleotides and amino acids were loaded onto SPION surfaces via this …
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Multiphysics-based Fluidic Manipulation of Particles: An Experimental and Numerical Study
… with superparamagnetic iron oxide nanoparticles (SPIONs), to develop an effective cure for spinal cord injury (SCI). In SCI patients, long distance axonal connections are lost because most axons in the adult mammalian central nervous system fail to regenerate after injury. Using an external …
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Novel approaches and pharmacological considerations in melanoma treatment
… (SP) iron oxide nanoparticles (SPIONs) have been selected and synthesised in-house as a drug delivery platform.3 These nano-carriers can encapsulate anti-melanoma drugs, allowing the NPs to function as drug delivery systems. Additionally, SP iron oxide cores possess properties …
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Physical and biological characterisation of clinically relevant combined MRI-radiation exposures with conventional and nanoparticle contrast agents
… for brain metastases patients treated with SRS. SPIONs were then tested in an in vivo mouse model with H460 xenograft tumours to detect any decrease in the rate of tumour growth caused by radiosensitisation.<br/><br/>Results:<br/>Dosimetry measurements validated Alanine, Gafchromic Film and …
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NOVEL EXPERIMENTAL APPROACHES AND THEORETICAL MODELS FOR IMPROVING SENSITIVITY AND INFORMATION CONTENT OF NMR AND MRI SPECTROSCOPY
… in liquid-crystalline media. Finally the use of SPIONS--superparamagnetic iron oxide nanoparticles--as contrast agents is a relatively new approach to enhance information content in MRI studies; this is particularly true for SPIONs that have been surface-functionalized to achieve an …
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Fundamental studies and applications for the development of novel MRI contrast agents: Hyperpolarized xenon-129 and superparamagnetic iron oxide nanoparticles
… and superparamagnetic iron oxide nanoparticles (SPIONs). The largest `Achilles' Heel' of MR techniques is their inherent lack of detection sensitivity due to the exceedingly small magnitude of the nuclear spins, giving rise to small thermal polarizations. Chapter 2 reviews strategies for …
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Developing a Microbubble-based Contrast Agent for X-ray Phase Contrast Imaging to Detect Neovasculature in Breast Cancer
… with superparamagnetic iron oxide nanoparticles (SPIONs). MBs were then immobilized in agar at three concentrations: 5×10⁷ (high), 5×10⁶ (moderate), and 5×10⁵ MBs/ml (low). MBs were imaged by synchrotron at the Canadian Light Source with In-line phase contrast imaging (PCI) and Multiple-image …
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Polymer-mediated assembly of MRI contrast agents and their use in imaging of vascular defects
… hyperbranched polyglycerol (HPG) in assembling SPIONs in the form of spherical clusters. By controlling the cluster size and molecular architecture of the polymer coating, optimal relaxivity of the SPIONs was achieved for sensitive imaging. In Chapter 5, the SPION clusters are further improved …
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The Search for New/Unknown Signals
… superparamagnetic iron oxide nanoparticles (SPIONs). This dissertation will show the design and optimization of iDQC anisotropy by a series of phantom experiments. A set of numerical simulations will then be provided for a sub-voxel level explanation. We will also demonstrate how the newly …
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Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
… therapeutic benefit when loaded to α-MSH-SPIONs that can wide the horizons of clinical pharmacology field.
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New approaches to diagnostic imaging: Magnetic particle imaging for human functional neuroimaging and short mid-field MRI magnet design
… with superparamagnetic iron oxide nanoparticles (SPIONs), and by minimizing background signal levels which are not modulated by functional activity, it offers a promising alternative. However, there are no approved SPION tracers for human use that are well-suited to MPI, and we have little …
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Self-assembly of anisotropic nanostructures and interferometric spectroscopy
… for assembling superparamagnetic nanoparticles (SPIONs) into structure-controlled 1D chains in a rotating magnetic field. The length of the SPION chains can be well described by an exponential distribution, as is also seen in SPION chains in a static field. In addition, the maximum chain length …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… vehicle containing 70% lactose (w/w), 20% SPIONs (w/w) and 10% fluorescent nanospheres (w/w). Mice were insufflated with NIMs delivery vehicle in the presence of magnetic field dependent targeting to the left ventral lung after thoracotomy; controls were insufflated with the NIMs in the …