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Showing 1 to 16 of 16 for “"SPIO"”.
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Chemical and Biological Strategies for Improving the Sensitivity of SPIO-Enhanced MR Imaging
… contrast agents, superparamagnetic iron oxide (SPIO) nanoparticles, offer an especially attractive platform for tumor targeting, owing to their strong magnetic properties, high degree of biocompatibility and ease of post-synthesis functionalization. One of the only limiting factors to these …
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Diagnostik fokaler Leberläsionen
… Patienten, die im Zeitraum 2/96 bis 3/96 eine SPIO gestütze MRT-Untersuchung der Leber erhalten haben, wurde die diagnostische Leistungsfähigkeit der MRT und SPIO-MRT mit dem korrespondierenden biphasischen Spiral-CT verglichen. Dabei ergaben sich insbesondere bezüglich der …
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Targeted magnetic hyperthermia for lung cancer
… materials, such as superparamagnetic iron oxide (SPIO) nanoparticles, when subjected to an alternating magnetic field. However, inadequate delivery of magnetic nanoparticles to tumor cells can result in sub-lethal temperature change and induce resistance. Additionally, non-targeted delivery of …
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Multimodality Imaging of Tumor Vasculature and Metabolism
… chapter 3, 20 nm super-paramagnetic iron oxide (SPIO) particles were conjugated with a novel monoclonal antibody PGN635 to image the exposed phosphatidylserine (PS) on the tumor vascular endothelial cells and evaluate the enhanced exposure of PS as a result of radiation therapy in mice …
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Synthesis and functionalisation of metal and metal oxide nanoparticles for theranostics
… and superparamagnetic iron oxide nanoparticles (SPIOs) were synthesised using a range of techniques including reduction, co-precipitation and spinning disc technology. SPIOs were primarily synthesised via a co-precipitation method using iron (II) chloride, iron (III) chloride and ammonia; a …
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Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
… cells labeled with superparamagnetic iron oxide (SPIO) labeling, and the serial changes of infarct volume in brain magnetic resonance image (MRI). MRI analysis with the SPIO-labeled cells indicated more even distribution in the animals with IA-MSCs/Ngn1 than the one with IC-MSCs/Ngn1. The animals …
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Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres
… superparamagnetic iron oxide nanoparticles (SPIOs). Our lab has shown that cell tracking with magnetic resonance imaging (MRI) has very high sensitivity, but low specificity and quantification of iron labeled cells is difficult. MPI cell tracking could overcome these limitations. A MomentumTM …
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DENDRITIC CELLS IN A MURINE MODEL OF BREAST CANCER: FUNCTIONAL AND PHENOTYPIC EVALUATION USING NANOPARTICLES
… set a DCs labelling protocol with commercial SPIO (Endorem®) evaluating Iron content using Perl’s staining and relassometry. Time and dose-response kinetic evaluations allowed to define as optimal labelling conditions the use of 200 μg Iron of Endorem®/ ml of culture for 16 hours. Cell …
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Magnetic particle imaging for intraoperative breast cancer margin assessment and functional brain imaging
… of superparamagnetic iron oxide nanoparticles (SPIOs). MPI boasts high sensitivity, zero background signal, positive contrast, fast temporal resolution, and quantitative detection. The field of MPI is currently preclinical, and this work aims to scale MPI to human sizes by developing and …
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Magnetic Resonance Imaging of a Natural Killer Cell Therapy in a Mouse Model of Prostate Cancer
… a superparamagnetic iron oxide nanoparticle (SPIO). A subcutaneous PC-3M tumour model was used to investigate tracking of KHYG-1 in vivo using the bSSFP sequence. Four days after administration, KHYG-1 accumulation in the tumours was detected by histology but not by MRI, although labeled …
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An exploration of women entrepreneurs' competency development process in pursuit of entrepreneurial opportunities in the manufacturing sector in Ghana
Since 1993, like other African countries, Ghana's governments have sought to promote the private sector and entrepreneurship-led economic development, prioritising industrialisation and women empowerment. Successive governments have sought to achieve this through relevant policies prioritising …
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Determining optimum imaging parameters for SWIFT: application to superparamagnetic iron oxides and magnetized objects.
A relatively new pulse sequence in MRI known as SWIFT, sweep imaging with Fourier transformation, has been shown to effectively image spins with both short and long transverse and longitudinal relaxation rates. It is desirable to have equations that accurately describe the signal of spins when …
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Conservation of polychaete biodiversity within the Port Stephens-Great Lakes Marine Park
… habitats did not differ. High abundance of Spio pacifica (Spionidae) within the D. australis habitat, high abundance of Lumbrineris cf latreilli (Lumbrineridae) in sand habitat, and differences in the abundance of Mediomastus australiensis (Capitellidae) were responsible for the …
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CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM
The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and …