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Showing 1 to 17 of 17 for “"SPI1"”.
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Mechanisms of signal integration: Regulation of the SPI1 T3SS
… encoded on Salmonella pathogenicity island 1 (SPI1). The system is controlled by three AraC-like regulators HilD, HilC, and RtsA, which form a complex feed forward loop to activate expression of hilA, encoding the main transcriptional regulator of T3SS structural genes. This system is tightly …
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A tale of two proteins: relationship between HilD & FliZ in SPI1 regulation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Integration of small RNAs in the control of Salmonella pathogenicity island 1(SPI1)
… encoded on Salmonella pathogenicity island 1 (SPI1). The SPI1 T3SS directly injects several effector proteins into host cytosols, resulting in host actin rearrangement and engulfment of the bacteria. HilA activates transcription of the SPI1 structural components and effector proteins. Three …
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The Role of Periplasmic Disulfide Bond Status in the Regulation of the Salmonella SPI1 Type Three Secretion System
… via the Salmonella Pathogenicity Island I (SPI1) type III secretion system (T3SS) to induce inflammatory diarrhea and bacterial uptake into intestinal epithelial cells. The master SPI1 regulatory gene hilA is controlled directly by three AraC-like regulators: HilD, HilC and RtsA. A …
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Regulation of the Salmonella Pathogenicity Island 1 Type Three Secretion System
… encoded on Salmonella pathogenicity island 1 (SPI1). The SPI1 TTSS injects effector proteins into the cytosol of host cells where they promote actin rearrangement and engulfment of the bacteria. HilC, HilD, and RtsA activate expression of SPI1 genes by binding upstream of the master regulatory …
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Regulation of virulence in Salmonella enterica
… uses the Salmonella Pathogenicity Island I (SPI1) Type Three Secretion System (T3SS) to invade intestinal epithelia in the distal ileum of the host small intestine. HilA, a master regulator of the system, determines the level of SPI1 T3SS in the cell. Three AraC-like regulators, HilD, HilC, …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
Salmonella Pathogenicity Island 1 (SPI1) encodes a Type-3 secretion system (T3SS) essential for Salmonella invasion of intestinal epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory …
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Anpassung von Salmonella spp. an neue Wirte durch horizontalen Transfer translozierter Effektorproteine
… wurde die Salmonella-Pathogenitätsinsel 1 (SPI1), später SPI2 erworben. Beide Inseln kodieren jeweils einen Typ-III-Translokationsapparat und dazu gehörende trans- lozierte Effektorproteine, welche die Wirtszellreaktionen zum Vorteil des Pathogens modulie- ren. Die Inseln sind zu …
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
… is encoded on Salmonella Pathogenicity Island 1 (SPI1). The SPI1 TTSS forms a needle complex through which effector proteins are injected into the cytosol of host cells where they induce engulfment of the bacteria. We identified two regulatory proteins, termed RtsA and RtsB, which are encoded in …
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4D Ex Vivo Crispr/Cas9 Whole-Genome Screen to Identify Genes Regulating Lung Cancer Metastasis
… enriched in the Primary and Metastasis samples. SPI1 was identified as the central node in network analysis of the Primary and Metastases and present in every sample. SPI1 was validated <em>in vitro</em> as a novel transcription factor involved in lung cancer metastasis.</p>
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Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
… monocytes. Mutation of the gene encoding PU.1, SPI1 in humans and Sfpi1 in mice, is associated with AML. We hypothesized that reduced expression of PU.1 in Sfpi1BN/BNmyeloid cells will result in the development of AML in transplanted mice due to reduced repression of E2F1, leading to …
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Charakterisierung eines Typ III-Sekretionssystems für Virulenzproteine aus Salmonella typhimurium
… eindeutig identifiziert werden. Da in einer SPI1-Mutante, die einen Defekt im Typ IIISekretionsapparat hat, keine Nadel-Komplexe mehr angereichert werden konnten, liegt die Vermutung nahe, dass es sich bei den Nadel-Komplexen, isoliert aus S. typhimurium- Wildtyp, um die SPI1-Strukturen …
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Evolution mikrobieller Pathogenität: Salmonella Pathogenitätsinsel 2 als Paradigma für horizontalen Gentransfer
… haben, wie es im Invasions-Virulon von SPI1 der Fall ist. Vielmehr sind die SPI2-Effektoren vermutlich in mehreren Schritten im Laufe der Evolution in das Genom von Salmonella spp. gelangt und möglicherweise auch z.T. wieder deletiert worden. Die Bedeutung der Verteilung dieser …
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Substratspezifität der nicht-dbl-homologen G-Nukleotid-Austauschfaktoren SopE und SopE2 aus Salmonella typhimurium
… vermitteln ebenso wie einige außerhalb von SPI1 gelegene Effektoren (z. B. SopE2) zentrale Virulenzeigenschaften. Zusätzlich zu diesen konservierten Genen gibt es einige variable Effektoren wie SopE, die erst in jüngerer Zeit erworben wurden und auch heute noch durch horizontalen Transfer …
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… the <em>Salmonella</em>pathogenicity island 1 (SPI1) encoded type III secretion system (T3SS), a needle-like complex composed of over 20 proteins that translocates effector proteins directly into the host cell cytosol. <em>Salmonella</em> possess a second type III secretion system encoded on …
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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
… as the prevalence of NOTCH1 mutations and TCF7-SPI1 fusion is higher in dasatinib responders than non-responders, both of which are known to be associated with T-cell differentiation. Because clonal expansion often occurs during leukemogenesis, resulting in heterogeneity in the leukemia cell …
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Transcriptional regulation in Salmonella enterica by the Lysr-type factor LeuO
… footprinting, se determinó que la represión de SPI1 se realizaba a través de dos vías independientes, siendo una de ellas la activación de la transcripción del represor HilE. Además, se observó una drástica disminución en la capacidad invasiva de S. Typhimurium en condiciones de expresión de …