Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"SPECT imaging"”.
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List Mode Reconstruction in X-Ray CT and SPECT Imaging
Since the introduction of tomography imaging in the 1970s, it has become an indispensable tool in medical imaging, driving continuous advancements in pursuit of higher image quality, reduced scan time, lower radiation doses, and more recorded attributes. List mode data, which records all attributes …
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Fixed and Adaptive Multiple-Pinhole Apertures for Brain SPECT Imaging
Single-Photon Emission Computed Tomography (SPECT) is a medical imaging modality where a radiopharmaceutical's emissions are captured with one or more gamma cameras deployed about the patient. During tomographic acquisitions, the SPECT camera(s) collect gamma-ray projection images created by …
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A Pretargeted Spect Imaging Strategy Employing Technetium-99M Based on Bioorthogonal Diels-Alder Click Chemistry
… synthesized and tested for use in pretargeting SPECT imaging that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the <sup>99m</sup>Tc-peptide complexes for maximum tumor targeting …
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Charge sharing energy correction in CdTe sensors using machine learning and its application in SPECT imaging
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Room temperature semiconductor detector performance enhancement for multi-energy spect imaging system development and its application in alpha emitter radiopharmaceutical therapy
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Development of the MRC-SPECT-II system: a MR-compatible small-animal SPECT system based on semiconductor imaging spectrometers and a Synthetic Compound-Eye gamma camera design
Single photon emission computed tomography (SPECT) is a routine molecular imaging modality, widely appreciated in any nuclear medicine department and clinically used for more than 50 years. Whereas SPECT instrumentation used in clinical and preclinical practice is still mainly based on cumbersome …
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Molecular imaging of gene transduction in cardiac transplantation
… transduction was established with the use of SPECT imaging. Following gene transfer, the recipients were injected with ⁹⁹mTc in the first set of experiments (Chapter 3) or with radioactive ¹²³I (Chapter 4) and imaged under a SPECT scanner. Radioactive isotope uptake in the Ad-NIS group was …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… approach. The development of non-invasive imaging methods and imaging biomarkers of response to immune checkpoint inhibitors could therefore provide important diagnostic and prognostic information. This project builds on existing technologies in Cambridge to develop structural and …
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Development of Receptor-Targeted Imaging Agents: Integrated Gallium Complexes and Conjugated Cyclopentadienyl Tricarbonyl Rhenium and Technetium Complexes
… in Single Photon Emission Computed Tomography (SPECT) imaging is 99mTc, the development of 99mTc-labeled phenyl-tropane analogs with high affinity for the dopamine transporter (DAT) would provide a useful tool for imaging disorders in this transporter system, such as clinical diagnosis of …
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Single photon emission computed tomography: performance assessment, development and clinical applications
This is a general investigation of the SPECT imaging process. The primary aim is to determine the manner in which the SPECT studies should be performed in order to maximise the relevant clinical information given the characteristics and limitations of the particular gamma camera imaging system …
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The registration of multimodality medical scans
… the current technology of MRI, CT, PET, and SPECT imaging. Possible uses and benefits of using registered data sets are then explained in this context. This is followed by a structured description of the general problem of data registration and a framework that can be used to solve it. …
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Statistical modeling of radiation detection and imaging system
In the development of SPECT system for imaging small animal in vivo, higher spatial resolution is continuously sought to provide improved spatial detail and image quality. However, the pursuit of high resolution often results in the poor photon collection efficiency and limited quantitative …
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Texaphyrin Architectures for Biomedical Applications
… tumour uptake and retention for in vivo MRI-SPECT imaging in orthotopic PC3 prostate cancer mice. Additionally, we further evaluated Mn-nanotexaphyrin for MRI applications, creating a novel one-pot instantaneous chelation and self-assembly protocol for this contrast agent. Evaluations on a …
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Evaluation of the effect of breast implants on the accuracy of the CT attenuation Correction (CTAC) map for SPECT/CT myocardial perfusion imaging: a phantom study
Background: Myocardial perfusion imaging (MPI) using single photon emission computedtomography (SPECT) imaging can assess myocardial viability and perfusion. However,overlying thoracic structures, such as ribs or breast tissue lead to gamma ray attenuation. Thisattenuation does not occur equally …
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Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
… delivered to cancer cells for diagnostic imaging or therapeutic purposes. Parts of this dissertation explore the development and preclinical evaluation of a radiolabeled antagonist peptide conjugate (RM2 = DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) …
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Development of high performance single photon emission computed tomography systems for simultaneous nuclear molecular imaging and magnetic resonance imaging
Simultaneous nuclear molecular imaging (NMI) and magnetic resonance imaging (MRI) have great potential for pre-clinical and clinical applications, especially for cell imaging in brain cancer models. We have pursued an intensive research effort to develop high-performance single-photon emission …
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Inverted compound eye camera for second generation MRI compatible SPECT system
… design of the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept inspired by compound eyes often found in small invertebrates. The MRC-SPECT II system is constructed with a total of 24 ICE-camera panels that consists of a …
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The development of MRI-compatible SPECT system
In recent years, combined MRI and nuclear imaging techniques such as PET and SPECT have received great attentions. MRI provides high-resolution anatomical and functional information along with an exquisite soft tissue contrast. Nuclear techniques could provide an excellent sensitivity to …
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