Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"SPAK"”.
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Structural Analysis of STE20-Related Proline-Alanine-Rich Kinase (SPAK)
Ste20-related proline-alanine-rich kinase (SPAK) is a kinase that regulates ion cotransporters including KCC, NKCC1, NKCC2 and NCC. Recently, SPAK was identified as a target regulated by the WNK (With No lysine (K)) family of protein kinases. Overexpression of WNK1 has been associated to a …
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Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets
… hyperphosphorylation of the downstream effector, SPAK, which overactivates NCC causing salt retention and hypertension. Mutations causing deletion of exon-9 in Cullin-3, which normally ubiquitylates WNKs for degradation, were recently discovered to cause the severest subtype of PHAII (PHA2E) with …
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Identifying Novel Functions of the WNK Pathway
… SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation chloride cotransporters. The pathway regulates ion transport across cell membranes, among other functions, and is implicated in human diseases including hypertension, cancer and neurological diseases. However, …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… coupled cotransporters. WNK kinases activate SPAK and OSR1 kinases, which then regulate the activity of cotransporters. My initial work within this pathway was focused on understanding the role of SPAK and OSR1 activation loop domain-swapping. I solved the structure of the inactive SPAK kinase …
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Autoinhibition and Chloride Sensing in the WNK1 Kinase
… via the activation of the WNK1 substrates OSR/SPAK. Prior investigation of the system has demonstrated that CCCs are activated by increasing con- centrations of extracellular salt and by intracellular phosphorylation from the OSR/SPAK kinases. Due to it ubiquity in mammalian cell types, a …
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Bedeutung der Interaktion von Calcineurin und SORLA für die Regulation des Na⁺,K⁺,2Cl⁻-Kotransporters (NKCC2) in der Niere
… wird diese durch die homologen Kinasen SPAK (SPS-related proline/alanine-rich kinase) und OSR1 (Oxidative stress responsive kinase 1), die hierzu ihrerseits phosphoryliert werden müssen. Der regulatorische Kontext dieser Kinasen ist mittlerweile gut charakterisiert. Über Mechanismen und …
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Physiological and pharmacological factors affecting sickle cell function
… evidence for the downstream involvement of SPAK/OSR1, although definitive evidence awaits phosphoproteomic studies. Overall, results provide a better and more comprehensive understanding of the pathogenesis of SCD with the potential to inform novel therapeutic approaches.
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Modeling Cable Harness Effects on Space Structures
Due to the high mass ratio of cables on lightweight spacecraft, the dynamic response of cabled structures must be understood and modeled for accurate spacecraft control. Models of cable behavior are reviewed and categorized into three major classes consisting of thin rod models, semi-continuous …
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
One of the hallmarks of AD is the formation of sticky protein clumps in the brain known as amyloid-beta (Aβ) plaques, which are formed from specific fragments of the amyloid precursor protein (APP). The intact form of APP is essential for synaptic function; however, much remains to be explored …