Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"SOX9"”.
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Role of Sox9 In Uterine Gland Development and Disease Initiation
… aim of this project was to study the role of SOX9 in the UGs. Preliminary studies revealed that Sox9 is mostly found in the nucleus of the GE. vii This observation led to the hypothesis that Sox9 plays a role in the formation and/or differentiation of the GE. To study the role of Sox9 in UGs …
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Characterization of the Role of SOX9 in Cartilage-Specific Gene Regulation
… we focus on the role the transcription factor SOX9 plays in activating cartilage-specific genes, specifically Col9a1 and Cartilage Link Protein (CRTL1). Previously, enhancers of these genes containing single SOX9 binding sites were shown to be activated through SOX9 binding. However, the …
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… of two SRY-related HMG-box (SOX) genes, SOX2 and SOX9, in human foetal lung progenitor cells. I show that although SOX2 is expressed in early stage progenitor cells it is dispensable for progenitor cell survival and self- renewal. By contrast, SOX9 is crucial for tip progenitor cell self-renewal …
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Specification of Stem Cells and Niche During Hair Follicle Morphogenesis
… WNT<sup>high</sup> cells is sufficient to confer SOX9+ cell fate to the WNT<sup>low</sup> cells. This suggested that the perpendicular asymmetric divisions that I observed in the developing HFs produce the WNT gradient, necessary for the establishment of SOX9+ cells. To further investigate the …
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Delineating the molecular mechanisms regulating chondrogenesis
Sox9, (SRY-type HMG box), has been shown to play a critical role throughout chondrogenesis. Haploinsufficiency of Sox9 in humans leads to a skeletal malformation syndrome known as campomelic dysplasia. To understand the regulation of Sox9 during chondrogenesis, the developing mouse limb was used to …
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Specification And Function Of Early Hair Follicle Stem Cells
… slow-cycling cells function as SCs, I focused on Sox9, an essential adult SC gene also expressed by early slow-cycling cells. Using Sox9-Cre for genetic marking and K14-Cre to embryonically ablate Sox9 revealed that the progeny of Sox9-expressing cells contribute to all skin epithelial lineages …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… key NSC transcription factors such as SOX2 and SOX9, in regulating self-renewal activity in GSCs and gliomagenesis. To study non-coding alterations and complex SVs, we compiled a large (n = 230) cohort of GBM tumours with whole genome sequencing data. We uncovered a lack of recurrent non-coding …
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Implication du facteur de transcription SOX9 dans la régulation du gène de la furine lors de la différenciation de la lignée chondrocytaire ATDC5
… aux niveaux d'ARNm du collagène de type H et de Sox9. Ce dernier est un facteur de transcription essentiel pour la formation de cartilage et qui porte un motif de liaison à l'ADN de type HMG. Les essais de transfections transitoires effectués avec un plasmide contenant la région codante de la …
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
… unknown. Here, I tackled this question with SOX9, a master regulator that diverts embryonic epidermal stem cells (EpdSCs) into becoming hair follicle stem cells (HFSCs). I triggered a temporal fate-switching by engineering mice to re-activate SOX9 in adult EpdSCs. Combining epigenetic, …
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Régulation de l'activité transcriptionnelle de Sox9 et Axl par des facteurs de transcription de la classe bZIP chez les cellules de Sertoli des testicules
… de leurs gènes cibles tels que Axl et Sox9. "--Sommaire.
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
… genes. Probing mechanism, I identified SOX9 as the crucial chromatin regulator of super-enhancers. While high levels maintain HFSC fate and absence results in alternative fates, low levels, e.g. during wound-repair, early lineage progression or culturing, permit fate plasticity. I showed …
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Development of a MACS-based strategy for isolating rare cell populations from animal tissue for transcription factor studies
… BAP-Lngfr mirrored that of our gene of interest, Sox9. We placed the expression of BAP-Lngfr under the promoter control of Sox9 by gene targeting the Sox9 locus in ES cells, from which transgenic animal tissue can be derived. Sox9 was chosen as our modeltranscription factor of interest for its …
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Caractérisation de l'expression des facteurs de transcription des groupes SOXD et SOXE au niveau du testicule chez la souris
… l'expression des facteurs de transcription Sox9, Sox5 et Sox13 chez la lignée cellulaire de Leydig murine MA-10 ainsi que de caractériser et de localiser leur profil d'expression à partir de testicules de souris entiers représentant trois différents stades de développement post-nataux. …
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<i>PTHR1/SOX9</i> and <i>IDH1/IDH2</i> Relative Expression in Primary Chondrocyte and Chondrosarcoma Cells Under the Synergistic Influence of Inducible Hypoxia and Extracellular Acidosis
… SRY-box transcription factor 9 (<em>SOX9</em>), and isocitrate dehydrogenase 1 and 2 (<em>IDH1/IDH2</em>). <em>PTHR1</em> and SOX9 keep chondrocytes in a proliferative state and delay their hypertrophy. On the other hand,<em> IDH1</em> and <em>IDH2</em> are metabolic enzymes that …
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The Role of MicroRNAs in Craniofacial Development
… neural crest cell migration and differentiation. Sox9 is a molecular marker of cranial neural crest cells and participates in their maintenance and ability to respond to chemotactic signals during migration. Investigation of Sox9 expression, between E9.5 and E12.5, showed ectopic Sox9 expression …
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The role of long non-coding RNA LINC00673 in lung tumorigenesis
… strongly correlates with the mRNA levels of SOX9, a major developmental regulator and oncogene in the lung context. Recently, evidence has emerged that developmental pathways are re-activated during LUAD progression. We hypothesized that LINC00673 might be involved in those phenomena through …
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Identifying sm22 as a key player in arterial diseases
… the key osteochondrogenic transcription factors Sox9. In accordance with the in vivo findings, expression of the aforementioned pro-inflammatory genes and Sox9 was up-regulated in Sm22<sup>-/-</sup> primary VSMCs and after Sm22 knockdown in PAC1 cells. Interestingly, Sm22 knockdown also led to …
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Digit formation during embryonic development of bats and mice
… in the bat FL may lead to elevated levels of Sox9 expression, and larger fields of mesenchymal condensations. This was tested by annotating Sox9 in the M. natalensis genome to further analyse the expression levels and associated ChIP-seq data. In addition the behaviour of condensing …
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