Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"SOX4"”.
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Characterisation of the role of Sox4 in mouse embryonic development
… of heart development. A developmental role for Sox4 has been shown in mouse cardiogenesis, as apparent by the phenotype of two published alleles. Both null and conditional null mutant alleles exhibit septation defects, oedema, and lethality by E14.5. However, the causative step in development, …
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Identification of TMEM2 as a SOX4 Transcriptional Target Involved in Breast Cancer Metastasis
… factor SRY (sex determining region Y)-box 4 (SOX4) regulates embryonic development and has been shown to drive the progression and metastasis of multiple solid cancer types. A common transcriptional target of SOX4 that mediates its effects in multiple cancer types has yet to be identified. …
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Caractérisation de l'expression et de l'activité des facteurs SOX dans le testicule adulte de souris
… ces résultats montrent que les facteurs Sox4, Sox8, Sox9 et Sox12 sont exprimés dans les cellules de Sertoli, que les facteurs Sox3, Sox4 Sox12, Sox13 et Sox18 sont retrouvés dans les spermatogonies et que les transcrits des facteurs Sox5, Sox6 et Sox30 sont présents dans les …
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Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
… NEUROG2 and CREB1 co-transcription, induce SOX4 expression, and promote SOX4-dependent chromatin remodeling. Genome-wide occupancy analysis revealed that SOX4 targets numerous SWI/SNF complex subunits and co-binds with NEUROG2 to enhance the expression of diverse neurogenic factors. The …
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Régulation de l'expression du gène Gja1 impliqué dans la formation de jonctions communicantes au niveau du testicules de souris
… de plasmides d’expression pour lesfacteurs Sox (Sox4, Sox8 e tSox9) ainsi qu’AP-1(cJun et cFos) avec des 5 plasmides rapporteurs de la luciférase portant différentes longueurs du promoteur Gja1. Enfin, le recrutement des facteurs de transcription à leurs éléments de régulation sur le promoteur …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… older. The second wave showed upregulation of Sox4 and Sox9, which are involved in kidney epithelial cell regeneration. Single cell ATAC sequencing (scATAC-seq) experiment confirmed the functional importance of these TFs in early ccRCC cells. Although the expression of these TFs in normal …
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MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
… profiling and could show that E2F3, CDKAL1, and SOX4 in 6p22, and YWHA (14-3-3) gene family members in 8q22 and 2p25, respectively, are major target oncogenes important for high grade disease.
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Identifying genetic biomarkers for diagnosis of prostate cancer in South African men
… group with p values <0.05; DAXX, EGFR, RASSF1, SOX4, and TIMP2, upregulated genes were ACACA, AR, CDKN2A, ERG and FASN but were also not statistically significant. The study shows similarly differentially expressed genes as seen in international studies. Of note PTEN, MKI67 and FASN which are …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
… of other SOX family members including SOX2, SOX4, SOX7 and SOX18. SOX17-deficient PAECs exhibited decreased proliferation rates and transcriptional analysis suggested this to be a result of decreased cyclin A (CCNA1) and cyclin B (CCNB1) expression and increased expression of p15 (CDKN2B), a …
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The development and evolution of vertebrate oxygen-sensing cells
… showed that the transcription factors Hand2, Sox4 and Sox11 are required for carotid body development. In addition, loss of the receptor tyrosine kinase Ret or the transcription factor AP-2β, which significantly affects sympathetic ganglion but not adrenal chromaffin cell development, has no …