Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"SOLVENT SELECTION"”.
-
Computer-aided rational solvent selection for pharmaceutical crystallization
Solvents play an important role in crystallization, a commonly used separation and purification technique in the pharmaceutical, chemical and food industries. They affect crystal properties such as particle size distribution, morphology, polymorphism etc. and therefore have consequences for the …
-
A computational approach to solvent selection for biphasic reaction systems
… targets of practical relevance for a rational solvent screening which requires thermodynamic information on coupled reactions and phase equilibria as input. Usually, the experimental determination of these data requires considerable laboratory effort. To minimize the experimental effort and to …
-
Modelling approaches for rational solvent selection in drug development, enhancing the solubility prediction of small molecules
… approach to select crystallisation and wash solvents. A case study using paracetamol and its impuritiesis considered.
-
Green engineering and gate-to gate life cycle assessments for pharmaceutical products
… products along with the development of a solvent selection table. The goal of this research was to determine how various processing and environmental metrics were affected by process improvements.</p> <p>The first drug was the pravastatin, which was made via a fermentation route. Four lab …
-
Hyperbranched And Polydimethylsiloxane Based Membranes For CO2 Capture
… membrane types.</p> <p>The results showed that solvent selection and polymer/solvent contact angle has the greatest effect of creating thin film layers in composite layer membranes. Also hyperbranched polymers included in a membrane matrix increased permeability. Lastly sol-gel coating of …
-
An Optical Aptamer-Based Carbon Nanosensor for Cortisol Detection
… This work touches on the importance of solvent selection in preserving the optical properties of SWCNTs while allowing for effective hormone solubilization. Results indicate that the sensor can detect cortisol concentrations from 37.5 μg/mL to 300 μg/mL and can distinguish cortisol from …
-
Comparison of extraction efficiency using ethanol and methanol for the extraction of mycosporin-like amino acids (MAAs) from Palmaria palmata
… efficiency of ethanol and methanol as extraction solvent for MAAs from Palmaria palmata. Dried and fresh seaweed biomass was subjected to solvent extraction using ethanol and methanol under identical conditions. The extracts were filtered and concentrated, and MAAs were analysed using appropriate …
-
Methodology for Pyrolysis-induced Thermal Runaway Analysis in Li-ion Batteries
… revealing behaviors that differ based on solvent choice. Our analysis discerned distinct thermal properties between LiFSI-carbonate and LiFSI-ether electrolytes. Specifically, carbonate-based electrolytes displayed a pronounced exothermic peak at 350°C, indicative of significant …
-
Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
… production of ePTFE-HA materials using a solvent infiltration technique. Surface interactions with blood show increased platelet adhesion on HA-modified surfaces, though evidence may suggest less platelet activation and erythrocyte lysis. Significant changes in mechanical properties of …
-
Application of machine learning methods for design of crystallisation processes
… of pharmaceutical drugs in a diverse range of solvents.;High throughput screening for analysing crystallisation outcomes and crystal habit of paracetamol in a diverse range of solvents was developed using Technobis Crystalline. Out of 94 solvents, paracetamol was observed to crystallise in 44 …
-
Developing strategies and equipment for continuous isolation of active pharmaceutical ingredients (APIs) by filtration, washing and drying
… during the crystallization process and the solvents selected for the crystallization process influence the performance and the efficacy of isolation. Lots of effort was made in the last few decades to understand how to improve the crystallization stage. Relatively less effort has been made …
-
Machine-assisted synthesis and development in pharmaceutical industry
… the underlying reaction mechanism(s), selection of chemical (intrinsic) and physical (process) parameters that affect the process objective(s), quantifying the nonlinear interactions between them, and lack of data. Reducing the cost and time for development of robust processes from …
-
The SSIP approach to solvation
… the strength of interactions within different solvents. A selection of profiles for a range of solvents are included as examples. The profiles provide a useful guide for how to tune interactions when designing systems which rely on intermolecular interactions for association. Consideration of …
-
Automated feedback in flow for accelerated reaction screening, optimization, and kinetic parameter estimation
… discrete variables-e.g. catalysts, ligands, and solvents-that, when paired with the continuous variables, give rise to changes in the reaction mechanism or kinetics. To address this problem, this thesis introduces a more general approach to reaction optimization with the construction of an …
-
NEW BIOCATALYTIC PLATFORMS FOR THE SYNTHESIS OF HIGHLY VALUABLE COMPOUNDS THROUGH INTENSIFIED BIOPROCESSES
… Particular attention has been drawn on the solvent selection and the process conditions: the use of novel green solvent 2,2,5,5-Tetramethyloxolane (TMO) in a biphasic system allowed a remarkable productivity improvement, nullifying byproducts (usually obtained using classical chemical …
-
Internal surface coating and photochemical modification of polypropylene microfiltration membrane
… including concentration of monomers, organic solvent selection, crosslinking agent, selection of an acid acceptor and reaction time were investigated. The choice of organic solvent was found to be critical for obtaining an even, smooth coating layer without significantly changing the membrane …
-
A Comprehensive Evaluation of Off-Gas Emissions From A Catalyst-Aided, Amine-Based, Post Combustion Capture of CO2 From Industrial Exhaust Gas Streams
… impact on the environment. For the amine solvent selection process two single amines: hexamethylenediamine (HMDA), and 2-amino-2-methyl-1-propanol (AMP), two polyethyleneimine (PEI) blends: HMDA/PEI and AMP/PEI and two 2-amino-2-methyl-1-propanol (AMP) blends: DMAE/AMP and BEA/AMP which …
-
Model-based experimental analysis of enzyme kinetics in aqueous-organic biphasic systems
… in hydrogel beads which are suspended in organic solvents is a promising approach for the production of hydrophobic fine chemicals. Due to the superposition of mass transfer, diffusion, and enzyme reaction the rational design of such immobilizates is rather complex. For this reason, a mechanistic …
-
Determination of descriptors by liquid-liquid partition and chromatographic methods
… glycol or dimethyl sulfoxide as the base solvent and n-heptane, 1,2-dichloroethane, 1-octanol or isopentyl ether as the counter solvent. These partition coefficient databases are analyzed using the solvation parameter model facilitating a quantitative comparison of these systems with other …
-
Understanding emergence of supramolecular chirality in lyotropic conjugated polymers
… (LCs) and its dependence on molecular design and solvent selection. Furthermore, it explores the impact of this chirality on device-relevant properties, such as charge carrier mobility and conductivity upon chemical doping. In Chapter 2, I explore the LC-mediated assemblies of conjugated polymers, …
Page 1 of 2