Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"SOD2"”.
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Critical role of ROS in capsaicin-induced hyperalgesia
… the role of mitochondrial antioxidant SOD2 in pain. Experiments were done to measure spinal levels of SOD2 protein and activity, inactivated SOD2 protein, and ROS accumulating dorsal horn cells after capsaicin injection to mouse foot with or without ROS scavengers. The capsaicin-induced …
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Consequences of Endogenous Mitochondrial Oxidative Stress in the Heart
… normal controls. In this study, the constitutive Sod2 knockout mouse model was used. All mice were treated daily with the SOD2 mimetic, Euk-189. For the first time, echocardiography was performed on constitutive Sod2 nullizygous mice. Sod2 mice were shown to have impaired systolic function, as …
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A pilot study to identify links between genetic variation and shoulder pain and dysfunction after breast cancer radiotherapy
… sites; three in TGF-ß, two in ATM, one in SOD2 and one in XRCC1, using PCR technologies and TaqMan allelic-discrimination probes. The resultant genotypes were analysed using multivariate analysis, including inferred haplotype analysis to search for association to shoulder pain and morbidity …
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Characterization of an in vitro exercise model and the effects of a metabolic endotoxemia on skeletal muscle adaptation to electric pulse stimulation
… coactivator 1- (PGC1-), superoxide dismutase 2 (SOD2), substrate metabolism, metabolic enzyme activity, heat stress markers, and pH. To recreate the inflammatory milieu observed in metabolic disease states we treated the myotubes with a low dose of 20 EU lipopolysaccharide (LPS). Following the …
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Mitochondrial dysfunction in hereditary optic neuropathies
… mitochondrial targeting sequence of nuclear gene SOD2 and the 3460/ND1 LHON mutation. Our results show that, in control population, the heterozygous SOD2 genotype is associated to a higher activity and quantity of MnSOD, particularly with respect to Val homozygotes. Furthermore, we demonstrated …
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The involvement of free radicals in the casual mechanism of Motor Neurone Disease
… (SOD I), manganese superoxide dismutase (SOD2), glutathione peroxidase (GSHPx) and catalase (CAT) at the site of motor neurone loss (i.e. the anterior horn in the spinal cord) showed a significant increase in the percentage of SOD2, in MND patients than controls, at the thoracic level. …
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Oxidative stress in endothelial cells of patients with coronary artery disease
… of mitochondrial superoxide dismutase (SOD2) in HSVECs from CAD patients, in particular those with T2D. Mitochondrially-derived reactive oxygen species (mtROS) are reported to contribute to oxidative stress and endothelial dysfunction in CAD and T2D and, as such, this increase in SOD2 …
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Mechanisms of Ipsapirone-Mediated Neuroprotection of Ethanol-Treated Fetal Rhombencephalic Neurons: Role of Endogenous Antioxidants
… dismutase (SOD1), Mn-superoxide dismutase (SOD2), and catalase.</p><p>The results of these studies demonstrate that ethanol induces an increase in ROS and that ipsapirone pre-treatment prevents this increase. Time-course studies of the expression and enzyme activity of SOD1, SOD2, and …
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Role of oxidative stress in photoreceptor degeneration
… to a superoxide dismutase 2 heterozygous mouse (Sod2+/~), with decreased mitochondrial antioxidant activity, to examine the effect on disease progression. Thirdly, mutants were treated with a mitochondrially targeted ubiquinone derivative (MitoQ), which is a powerful antioxidant, to try and slow …
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Influence of Growth Factors on Bovine Embryo Development
… dismutase (SOD; SOD1) and manganese (Mn) SOD (SOD2) in embryos was assessed. No significant treatment effect was observed on the expression of apoptotic and oxidative stress genes. Bax was expressed strongly (4-fold) in morulae with the addition of IGF-I, but was less prevalent in all other …
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Exploring the in vitro effects of Helichrysum petiolares for its potential to provide cardioprotective benefits against Doxorubicin toxicity
… expression, specifically superoxide dismutase 2 (SOD2) and cytochrome c. Results: The H. petiolare methanol extract exhibited potent antioxidant activity (IC50 = 4.42 μg/mL), surpassing ascorbic acid (IC50 = 4.78 μg/mL). Pretreatment with Dox, followed by 12.5 μg/mL H. petiolare methanol extract …
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… growth factor (Vegf), superoxide dismutase 2 (Sod2) and other genes encoding major antioxidant enzymes (AOE). Novel roles for HIF-2 alpha have been found not only in hematopoiesis, but also in the control of reactive oxygen species and mitochondrial homeostasis. The molecular mechanism by which …
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Explorando los canales de potasio KCNQ : una perspectiva en trastornos del neurodesarrollo y cardíacos
… neuronal (Kcnq2-5), del estrés oxidativo (Sod1 y Sod2) y la memoria (Chrna7, Chrna4 y Chrnb2). En ratones KD, se encontró un aumento de la sociabilidad, y un cambio en la memoria de reconocimiento a corto plazo. En animales adultos, la expresión de Sod1 y Sod2 aumentó, resaltando el potencial de …
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Endocannabinoid and lipid metabolism genes network analysis in adipose and liver tissue of dairy cows during the transition period
… CPT2, ACADVL, ACOX1), oxidative stress (SOD1, SOD2), and genes that are involved in inflammation (TLR9, TLR4, NFE2L2). Expression of CNR2 and NAPEPLD was greater at 7 d in LoBCS due to lower expression at the same time in HiBCS. The expression of FAAH was upregulated at d 7 and 20 in LoBCS than …
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The Distribution of Innate Antioxidant Enzymes in Rat Cochleas
… expression of GSH, Cu/Zn-SOD (SOD1), and Mn-SOD (SOD2) was performed. The cochleas were co-labeled with Phalloidin (hair cell markers) and DAPI (nucleus detection). The intensity of antioxidant expression was quantitatively evaluated along cochlear turns and hair cell rows using ImageJ？？ program. …
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Reaction of the marine flatworm Macrostomum lignano exposed to xenobiotics
… to exposure to the xenobiotics, including Prdx1, Sod2, and Mdr5. Of the ROS-detoxifying enzymes, only Gstp1 showed significant upregulation. Xenobiotics also disrupt nervous system function by restricting movement and delaying regeneration. Even at low concentrations (10 µM), fipronil and …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… for selected genes (CSF3, CX3CL1, FGF18, ID2, SOD2, Tenascin C) using quantitative real-time RT-PCR analysis. This study revealed a complex anti-2GPI-regulated gene expression profile in HUVEC in vitro. The novel chemokines and pro-inflammatory cytokines identified in this study may contribute …
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Characterising the Drosophila extracellular superoxide Dismutase gene
… the intracellular (SOD1) and<br/>mitochondrial (SOD2) SODs, have been identified and studied extensively<br/>demonstrating a clear link between SOD and oxidative protection and survival.<br/>Recently the sequence of a third sod gene, homologous to both the relatively poorly<br/>characterised …
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