Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"SOD1G93A mouse"”.
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MACROPHAGE RESPONSE TO INITIAL MUSCLE DENERVATION IN THE SOD1-G93A MOUSE MODEL OF AMYTROPHIC LATERAL SCLEROSIS.
… resistant (FR) and slow (S) NMJs. In the SOD1G93A mouse model of ALS, initial NMJ denervation occurs in the TA muscle (FF and FR fibers) between postnatal day (P)14 and P30, while little denervation occurs in soleus muscle (S and FR fibers) even late in disease. It is plausible that early …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… in treating ALS. Utilizing the widely used SOD1G93A mouse model, we investigated the effects of RASRx1902 treatment on slowing ALS disease progression by focusing on the hallmarks of ALS, specifically neuroinflammation, neuronal excitotoxicity, and hypermetabolism. With daily treatment of …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… The transgenic animal model of ALS was the G93A mouse that expresses a mutant form of human SOD1 carrying the Gly93 → Ala and develops motor neuron disease similar to familial ALS. With the lack of effective drug treatments for ALS and compelling preclinical data, new therapeutic strategies have …