Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"SOCS3"”.
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The role of SOCS3 in nuclear reprogramming and naïve pluripotency network integration
… Here I discover the JAK/STAT3 pathway regulator Socs3 as a key screen hit and describe this gene as a self-sufficient and powerful roadblock between the pluripotent identities. I show how a spectrum of its attenuated activities displayed in naïve pluripotent and reprogramming cells may be …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… time I observed a dose dependent increase of SOCS3, which is mostly understood as an inhibitor of STAT3 related pathways, in response to both IGF-i and tumor necrosis factor (TNF)-a, in human coronary artery smooth muscle cells. I also found that SOCS3 inhibits cell proliferation mediated by …
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Bedeutung der IL-6-Signaltransduktionsinhibitoren SHP2 und SOCS3 für die Desensitisierung des IL-6-Signalweges
… phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine signalling) are potent inhibitors of IL-6 signal transduction. Impaired function of SOCS3 or SHP2 leads to enhanced and prolonged IL-6 signalling. The inhibitory function of both proteins depends on their recruitment to …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
… SHP2 and for the STAT induced feedback inhibitor SOCS3. Therefore the relative contributions of SHP2 and SOCS3 to the repression of the IL-6 signal transduction were investigated. In this work it could be shown that SHP2 inhibits the Jak/STAT pathway in a SOCS3 independent manner requiring the …
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Untersuchungen zur Modulation der IL-6-Signaltransduktion und zur Funktion der feed back Inhibitoren SOCS1 und SOCS3
… expression of the feed back inhibitor SOCS3 in the early phase of differentiation. This would lead to the inhibition of IL-6 signalling. The second part of this thesis aimed at the characterization of the feed back inhibitors SOCS1 and SOCS3. It could be shown that endogenous SOCS3 is …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites …
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Regulation of suppressor of cytokine signalling 3 expression by the pro-inflammatory cytokine (IL-1beta) in vitro and inflammatory stimuli in vivo
… the IL-6-type cytokine signalling pathways, SOCS3 is also essential for regulating many immunological processes. In the first part of this thesis, we analyzed how IL-1beta regulates IL-6-induced SOCS3 expression. In hepatocytes IL-1beta alone does not induce SOCS3 expression but it …
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Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… IL-6 signalling via JAK/STAT is inhibited is via SOCS3 in a type of negative feedback loop whereby IL-6 induces transcription of SOCS3, which then attenuates further JAK/STAT signalling. SOCS3 can also be induced by cAMP. This is interesting as prostanoids, a type of drug used in the treatment of …
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The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
… cells. Suppressor of cytokine signalling 3 (SOCS3) is produced upon activation of the Janus kinase/Signal transducer and activator of transcription (Jak/Stat) pathway and this is an inducer of negative feedback inhibition and is implicated in regulation of intestinal homeostasis, with SOCS3 …
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Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
… that the tyrosine phosphatase SHP2 and SOCS3 do not act independently, but are functionally linked. Furthermore, we show that tyrosine 759 in gp130 is essential for both SHP2 and SOCS3, but not for SOCS1 to exert their inhibitory activities on interleukin-6 signal transduction. Besides …
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Interplay between Cannabinoids, SOCS3, and Autophagy Process in the Intestinal Epithelium with the Use of an Established in vitro Model System.
… Functionally, all three cannabinoids reduce SOCS3 protein expression. Blocking of autophagy reversed the cannabinoid-induced effect. In conclusion, CBD may have potential therapeutic application in CD where functional CNR1 receptor or autophagy is compromised and the regulatory protein, …
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Cytokine resistance in melanoma
… I found a high level constitutive expression of SOCS3 that did not further increase after cytokine treatment. Importantly, upon suppression of SOCS3 by short interfering RNA, cells became susceptible towards OSM and IL-6: they showed an enhanced STAT3 phosphorylation and a dramatically increased …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
… inhibitor suppressor of cytokine signalling 3 (SOCS3) in inhibition of the interleukin (IL)-6 type cytokine signal transduction is well documented. Expression of SOCS3 is induced via the STAT transcription factors, and it exerts its inhibitory effect via interaction with the phosphorylated Y759 …
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Untersuchungen zum crosstalk zwischen Interleukin-6 und Platelet-derived growth factor (PDGF) sowie zur Signaltransduktion von PDGF-Rezeptoren
… of the IL-6-induced feedback-inhibitor SOCS3. It was shown in several cell lines and primary cells that this crosstalk-mechanism leads to an enhanced STAT1 and STAT3 phosphorylation. An influence on ERK1/2-activation was not found. Several experiments, where multiple kinase inhibitors …
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Vergleich der Signaltransduktion von Interleukin-6 und Interleukin-10 in primären humanen Makrophagen
… Although LPS induces the feedback inhibitor SOCS3 in macrophages, inhibition of IL-6 signal transduction by LPS occurs rapidly and does not dependent on gene transcription. Pretreatment of macrophages with IL-10 inhibits subsequent STAT3 activation by IL-6 whereas IL-10-induced STAT3 …
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