Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"SOCS3"”.
-
The role of SOCS3 in nuclear reprogramming and naïve pluripotency network integration
… Here I discover the JAK/STAT3 pathway regulator Socs3 as a key screen hit and describe this gene as a self-sufficient and powerful roadblock between the pluripotent identities. I show how a spectrum of its attenuated activities displayed in naïve pluripotent and reprogramming cells may be …
-
Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… time I observed a dose dependent increase of SOCS3, which is mostly understood as an inhibitor of STAT3 related pathways, in response to both IGF-i and tumor necrosis factor (TNF)-a, in human coronary artery smooth muscle cells. I also found that SOCS3 inhibits cell proliferation mediated by …
-
Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites …
-
Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites …
-
Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… IL-6 signalling via JAK/STAT is inhibited is via SOCS3 in a type of negative feedback loop whereby IL-6 induces transcription of SOCS3, which then attenuates further JAK/STAT signalling. SOCS3 can also be induced by cAMP. This is interesting as prostanoids, a type of drug used in the treatment of …
-
The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
… cells. Suppressor of cytokine signalling 3 (SOCS3) is produced upon activation of the Janus kinase/Signal transducer and activator of transcription (Jak/Stat) pathway and this is an inducer of negative feedback inhibition and is implicated in regulation of intestinal homeostasis, with SOCS3 …
-
Interplay between Cannabinoids, SOCS3, and Autophagy Process in the Intestinal Epithelium with the Use of an Established in vitro Model System.
… Functionally, all three cannabinoids reduce SOCS3 protein expression. Blocking of autophagy reversed the cannabinoid-induced effect. In conclusion, CBD may have potential therapeutic application in CD where functional CNR1 receptor or autophagy is compromised and the regulatory protein, …
-
Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
… to induce suppressor of cytokine signalling 3 (SOCS3) in HUVECs. Further investigation of this SOCS protein in the context of IL-6 and leptin signalling in endothelial cells would be of interest in terms of possibly elucidating the molecular mechanisms underlying the protective effects of cAMP. …
-
Loss of Gprc5A Enhances Survival In Normal and Malignant Lung Epithelial Cells By Eliciting Persistent Stat3 Activation Induced By Autocrine Lif
… cells is due to a decreased level of Socs3 protein, a negative inhibitor of the Lif-Stat3 signaling. Restoration of Socs3 inhibited the persistent Stat3 activation in <em>Gprc5a</em><sup>-/-</sup> cells. Lung adenocarcinoma cells isolated from <em>Gprc5a</em><sup>-/-</sup> mice also …
-
Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the expression and functional roles in neurodegenerative diseases
… such as LC3B and p62. Finally, knockout of SOCS3 enhances autophagy via TBK1 stabilisation. Conclusion: alterations in the expression of ESCRT proteins and SOCS3 may have a role in the pathogenesis of MND and could be new therapeutic targets for treating neurodegenerative diseases.
-
STAT3-protein interactions in IL-6/gp130 signaling
… for the downstream gene expression, including socs3, c-fos and p21. Additionally, the recruitment of p300 and RNA Pol II to the socs3 promoter is reduced in MEFs stably expressing STAT3-DN mutant which is deficient in the NH2-terminal domain. We also reported that the binding site of the STAT3 …
-
Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
… sind dabei die Mechanismen der Aktivierung von SOCS3 durch LMP1 und dem damit verbundenen möglichen Einfluss auf den transformierten Zustand einer Zelle. In dieser Arbeit konnte gezeigt werden, dass in den untersuchten Burkitt-Lymphomzellen das exprimierte virale Onkoprotein LMP1 des …
-
Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation
… cytokine expression and decreased SOCS1 and SOCS3 expression. Additionally, miR-19a and miR-19b were found to enhance signaling through the NF-κB and JAK-STAT pathways. Aim 2 results showed that miR-19a and miR-19b modulate diverse gene expression patterns, regulate inflammation, and induce …
-
Mechanisms of microglia induced retinal degeneration
… receptors. Suppressor of cytokine signalling 3 (SOCS3) negatively regulates the JAK/STAT pathway. In this study, a mouse strain with the deletion of two inhibitory genes (CX3CR1 and SOCS3) in myeloid cells was created (named LysMCreSOCS3fl/flCX3CR1GFP/GFP, abbreviated as DKO in this thesis). The …
-
HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
… showed that both gt1a and gt3a core upregulated SOCS3; this upregulation has been shown to influence the liver response to previously used antiviral therapies, as well as the induction of insulin resistance. Additionally, genes that were downregulated by gt1a and gt3a core are largely associated …
-
HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
… showed that both gt1a and gt3a core upregulated SOCS3; this upregulation has been shown to influence the liver response to previously used antiviral therapies, as well as the induction of insulin resistance. Additionally, genes that were downregulated by gt1a and gt3a core are largely associated …
-
Mutations In Stat3 Associated With Human Hyper Ige Syndrome Enhance Nfκb and Mapk-Mediated Gene Expression
… expression of the endogenous STAT3 target gene, Socs3, as assessed by quantitative real-time PCR (qPCR) in the RAW macrophage cell line. These observations indicate the HIES mutants dominantly suppress the transcriptional activity of wild type STAT3, albeit to varying degrees. All three HIES …
-
Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
… inflammasome activity. In this study SOCS2 and SOCS3 deficiency did not impact the inflammatory response to inflammasome-activating stimuli, including the highly antibiotic-resistant and encapsulated bacterium Klebsiella pneumoniae (Kp), ex vivo and in vivo. This study employed two strains of Kp …
-
Positional Cloning of Adiposity Genes in Ethnic Minorities of the Insulin Resistance Atherosclerosis Family Study
… gene Suppressor of Cytokine Signaling 3 (SOCS3), the GWAS-implicated Insulin Induced Gene 2 (INSIG2), and candidate genes suggested via GWAS in the IRASFS Hispanics are presented. Finally, initial results regarding candidates obtained through GWAS in the IRASFS African Americans are …
-
Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… but not spleen-derived macrophages in SOCS3-dependent manner. Taken together, the data presented in this thesis have defined new facets of how anti-viral responses are regulated by TLR activation, especially if multiple receptors are engaged simultaneously.
Page 1 of 2