Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"SOCS2"”.
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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
… specific substrates for proteasomal degradation. SOCS2 is a component of the multisubunit CRL E3 complex (CRL5<sup>SOCS2</sup>). SOCS2 plays important roles in several cancers and is involved in diabetes and inflammatory diseases. This work aims to understand the substrate recognition mechanism of …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
… role of supressor of cytokine signaling 2 (SOCS2) in CML and in normal hematopoiesis was investigated. Mice deficient for the Socs2 gene displayed normal steady-state hematopoiesis and hematopoietic stem cell (HSC) function. Transduction of bone marrow (BM) cells from Socs2-deficient mice …
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… metastasis in vivo. I identified and validated SOCS2 as a novel, direct and biologically relevant target of miR-194. My research supports a model whereby targeting of SOCS2 by miR-194 leads to activation of the JAK2/STAT3 and ERK1/2 signalling pathways, two key pathways involved in promoting PCa …
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Nutritional Regulation of Serum Insulin-Like Growth Factor-I Concentration in Cattle
… pathway, suppressor of cytokine signaling-2 (SOCS2) and cytokine-inducible SH2 protein (CIS). These results suggest that decreased IGF-I gene expression in the liver may be at least partially responsible for the decrease in circulating IGF-I concentration during food deprivation, and that the …
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
… regulating inflammasome activity. In this study SOCS2 and SOCS3 deficiency did not impact the inflammatory response to inflammasome-activating stimuli, including the highly antibiotic-resistant and encapsulated bacterium Klebsiella pneumoniae (Kp), ex vivo and in vivo. This study employed two …
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On the role of SOCS proteins in leptin signalling
… two members of the SOCS family, CIS and SOCS2, as new interaction partners of the LR. We studied the binding modus of SOCS proteins and demonstrated that the SOCS-box is essential for receptor interaction of CIS but not of other examined SOCS proteins. In addition, we demonstrated that …
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Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… of the suppressor of cytokine signaling 2 (SOCS2), which causes proteasome-dependent degradation of TRAF6. Therefore, our report provides insight into the intracellular signaling pathways triggered to prevent aberrant inflammation and tissue damage. Taken together, our data demonstrate novel …