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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 13 of 13 for “"SOCS1"”.

  1. The intrinsic role of SOCS1 in intestinal epithelial cells

    Emami, Seyed AlirezaUniversité de Sherbrooke2021

    The SOCS1 protein negatively regulate cytokine signaling. To define its role in intestinal epithelial cells (IEC), our laboratory created a mouse model of Socs1 gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative …

    sherbrooke Repository record

  2. Experimentelle Untersuchungen zur Expression von SOCS1 an humanen Zelllinien

    Kürten, PaulineUniversität Ulm

    ulm-diss Repository record

  3. Molecular Characterisation of Diffuse Large B-cell Lymphoma in South Africa

    Ramorola, Beatrice RelebogileDepartment of Pathology2022

    … of the Suppressor of cytokine signalling 1 (SOCS1) gene. SOCS1 has been recently reported to be a frequently altered gene in DLBCL, but molecular pathological studies on the role of SOCS1 in DLBCL are scarce. Using cell line models, basal SOCS1 gene and protein expression levels were …

    cape-town Repository record

  4. Genomic investigation of primary immunodeficiency

    Rae, WilliamUniversity of Cambridge2021

    … between PID and rare deleterious variants in SOCS1, IVNS1ABP and TRAF3. In two families with autoimmunity and immunodeficiency I investigated the impacts of heterozygous deleterious variants in SOCS1. Patients showed reduced suppressor of cytokine signalling 1 (SOCS1) protein leading to …

    cambridge Repository record

  5. From Phenotype to Genotype: Discovery of New Molecular Primary Immunodeficiencies

    Zhang, ZinanUniversity of Cambridge2021

    … patients, we identified PTPN2 and SOCS1 haploinsufficiency due to a combination of common and rare variants as genetic causes of CVID. These patients had loss of TC-PTP and SOCS1 protein as well as hyper-phosphorylation of STAT1. This dissertation closes with a tantalizing …

    cambridge Repository record

  6. A Dual-Domain Peptide Strategy for Targeted Regenerative Repair

    Li-Wei Teng (2272204)2026

    … derived from suppressor of cytokine signaling 1 (SOCS1; KIR), fused to a TAT cell-penetrating peptide (KIR-TAT) to promote intracellular delivery and attenuation of pro-inflammatory signaling pathways. Collectively, this dual-domain design seeks to confine therapeutic activity to the target tissue …

    uic

  7. Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation

    Sahebdel, Faezeh2024

    … cytokine expression and decreased SOCS1 and SOCS3 expression. Additionally, miR-19a and miR-19b were found to enhance signaling through the NF-κB and JAK-STAT pathways. Aim 2 results showed that miR-19a and miR-19b modulate diverse gene expression patterns, regulate inflammation, …

    umn Repository record

  8. Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen

    Ufartes Mas, Roser2012

    … von SHP2-Varianten in vitro mit Hilfe eines SOCS1-Luciferase-Assays. Bei gain of function bot sich der Versuch der allelspezifischen Inhibition von PTPN11-Mutanten mit Hilfe der RNAi-Technik an. Schließlich sollte ein Mausmodell für das NS und das LS etabliert werden, da es zu Beginn dieser …

    goettingen Repository record

  9. Insights into Virus-Host Interactions: Regulation of Cytokine Signaling Is a Virulence Determinant of West Nile Virus

    Keller, Brian Christopher2010

    … expression of a dominant-negative form of SOCS1 partially restored IFN signaling during TX02 infection indicating that SOCS proteins do in fact participate in virus-induced signaling suppression. Importantly, WNV regulation of signaling was not restricted to IFNalpha /beta but included …

    utswmed Repository record

  10. THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE

    Cameron, Brent D.Case Western Reserve University School of Graduate Studies2013

    … of ifn¿¿, il-¿¿1¿¿, tnf¿¿, il-¿¿10, il-¿¿4, and socs1. Importantly, this work implicated the interferon response factors (IRFs) in controlling the microglial response to A¿¿ that is, in part, regulated by IRAK4 kinase activity. Analysis of whole brain homogenates revealed significant reductions …

    ohiolink Repository record

  11. Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD

    Corbett, JenniferNational University of Ireland Maynooth2016

    … MSC through suppressor of cytokine signaling 1 (SOCS1) inhibition resulting in the enhancement of MSCγ suppression of CD3+ T cells and increased indoleamine 2,3-deoxygenase (IDO). For the first time, we have shown that a novel CsA formulation, SmPill® provided safe and superior efficacy in …

    maynooth Repository record

  12. Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations

    Alshammari, AEM2020

    … significantly increased levels of TLR2, LC3, Socs1, Arg1, in T. gondii infected mice compared to non-infected mice, but decreased levels of NMDAR1, Lamp2, P62, Beclin-1 and iNOS. No significant difference was observed in the levels of Tau and APP between infected and non-infected mice. The …

    salford Repository record

  13. The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia

    김, 희영2011

    … pathway, I firstly tested the expression of SOCS1/3 by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). As a result, their expressions were not induced by curcumin. Also, I examined the phosphorylation of SHP-2 by immunoprecipitation in microglia. Treatment of microglial cells with …

    ajou Repository record