Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"SOCS1"”.
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The intrinsic role of SOCS1 in intestinal epithelial cells
The SOCS1 protein negatively regulate cytokine signaling. To define its role in intestinal epithelial cells (IEC), our laboratory created a mouse model of Socs1 gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative …
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Untersuchungen zur Modulation der IL-6-Signaltransduktion und zur Funktion der feed back Inhibitoren SOCS1 und SOCS3
… the characterization of the feed back inhibitors SOCS1 and SOCS3. It could be shown that endogenous SOCS3 is tyrosine phosphorylated upon stimulation of cells with IL-6 and other IL-6-type cytokines like OSM. Most interestingly, the recruitment of SOCS3 to the tyrosine motif pY759 of gp130, which …
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Molecular Characterisation of Diffuse Large B-cell Lymphoma in South Africa
… of the Suppressor of cytokine signalling 1 (SOCS1) gene. SOCS1 has been recently reported to be a frequently altered gene in DLBCL, but molecular pathological studies on the role of SOCS1 in DLBCL are scarce. Using cell line models, basal SOCS1 gene and protein expression levels were …
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Untersuchungen zu molekularen Mechanismen der Leptin-Rezeptor-Desensitivierung
… Inhibition der LEPRb Signaltransduktion durch SOCS1 oder SOCS3 wurde in Reportergen Assays mit einem STAT3 responsivem Promotor untersucht. Dabei konnte die Interaktion mit Tyr 985 bestätigt und Tyr 1077 als neue Bindungsstelle identifiziert werden. Darüber hinaus wurde erstmals auch SOCS1 als …
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Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
… essential for both SHP2 and SOCS3, but not for SOCS1 to exert their inhibitory activities on interleukin-6 signal transduction. Besides SHP2 also SOCS3 interacts with a peptide corresponding to the tyrosine 759 motif of gp130. Taken together, our results suggest differences in the function of …
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Genomic investigation of primary immunodeficiency
… between PID and rare deleterious variants in SOCS1, IVNS1ABP and TRAF3. In two families with autoimmunity and immunodeficiency I investigated the impacts of heterozygous deleterious variants in SOCS1. Patients showed reduced suppressor of cytokine signalling 1 (SOCS1) protein leading to …
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From Phenotype to Genotype: Discovery of New Molecular Primary Immunodeficiencies
… patients, we identified PTPN2 and SOCS1 haploinsufficiency due to a combination of common and rare variants as genetic causes of CVID. These patients had loss of TC-PTP and SOCS1 protein as well as hyper-phosphorylation of STAT1. This dissertation closes with a tantalizing …
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A Dual-Domain Peptide Strategy for Targeted Regenerative Repair
… derived from suppressor of cytokine signaling 1 (SOCS1; KIR), fused to a TAT cell-penetrating peptide (KIR-TAT) to promote intracellular delivery and attenuation of pro-inflammatory signaling pathways. Collectively, this dual-domain design seeks to confine therapeutic activity to the target tissue …
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Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation
… cytokine expression and decreased SOCS1 and SOCS3 expression. Additionally, miR-19a and miR-19b were found to enhance signaling through the NF-κB and JAK-STAT pathways. Aim 2 results showed that miR-19a and miR-19b modulate diverse gene expression patterns, regulate inflammation, …
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Untersuchungen über Veränderungen des Epigenoms bei der chronischen lymphatischen Leukämie
… und TIMP3 (3.1%). For DAPK2, hMLH1, MGMT, p73, SOCS1 and TIMP2 no hypermethylation was detected. Hypermethylation of at least one gene was observed in 90.6% of the samples. Up to 7 of 17 gene promoter regions examined were concurrently methylated. Hypermethylation occurred in all Rai stages …
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Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen
… von SHP2-Varianten in vitro mit Hilfe eines SOCS1-Luciferase-Assays. Bei gain of function bot sich der Versuch der allelspezifischen Inhibition von PTPN11-Mutanten mit Hilfe der RNAi-Technik an. Schließlich sollte ein Mausmodell für das NS und das LS etabliert werden, da es zu Beginn dieser …
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Molecular analysis of innate immunity in type 1 diabetes
… and the suppressor of cytokine signalling (SOCS1), a strong inhibitor of IFN-γ signalling. TRAIL and FASL-mediated suppression of IP-10, and upregulation of Socs1 transcription, rendered the NOD-islets less susceptible to immune destruction in T1D. Proinflammatory cytokine IFN-γ was not …
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Insights into Virus-Host Interactions: Regulation of Cytokine Signaling Is a Virulence Determinant of West Nile Virus
… expression of a dominant-negative form of SOCS1 partially restored IFN signaling during TX02 infection indicating that SOCS proteins do in fact participate in virus-induced signaling suppression. Importantly, WNV regulation of signaling was not restricted to IFNalpha /beta but included …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… of ifn¿¿, il-¿¿1¿¿, tnf¿¿, il-¿¿10, il-¿¿4, and socs1. Importantly, this work implicated the interferon response factors (IRFs) in controlling the microglial response to A¿¿ that is, in part, regulated by IRAK4 kinase activity. Analysis of whole brain homogenates revealed significant reductions …
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Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD
… MSC through suppressor of cytokine signaling 1 (SOCS1) inhibition resulting in the enhancement of MSCγ suppression of CD3+ T cells and increased indoleamine 2,3-deoxygenase (IDO). For the first time, we have shown that a novel CsA formulation, SmPill® provided safe and superior efficacy in …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… pathway, I firstly tested the expression of SOCS1/3 by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). As a result, their expressions were not induced by curcumin. Also, I examined the phosphorylation of SHP-2 by immunoprecipitation in microglia. Treatment of microglial cells with …
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Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations
… significantly increased levels of TLR2, LC3, Socs1, Arg1, in T. gondii infected mice compared to non-infected mice, but decreased levels of NMDAR1, Lamp2, P62, Beclin-1 and iNOS. No significant difference was observed in the levels of Tau and APP between infected and non-infected mice. The …