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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 7 of 7 for “"SOCS proteins"”.

  1. On the role of SOCS proteins in leptin signalling

    Lavens, D2006

    … signalling must be under stringent control. SOCS3 and PTP1B are the best characterized mediators of leptin signalling termination. In this work we focus on the role of SOCS proteins in leptin receptor signalling. SOCS proteins are typically inhibitors of cytokine receptor signalling and …

    ghent Repository record

  2. SOCS proteins and cytokine signalling: the many faces of the SOCS box

    Piessevaux, Julie2008

    ghent Repository record

  3. Effects of DFO-Induced Hypoxia on Key Signaling Mediators

    Candelora, Jennifer2014

    … the suppressors of cytokine signaling (SOCS) proteins, negative regulators of the JAK/STAT pathway, were investigated and detected via RT-PCR. These results suggest that there is an up-regulation of the SOCS proteins under hypoxia, and it may play a role in a form of neuroprotection by …

    shu-thes Repository record

  4. Insights into Virus-Host Interactions: Regulation of Cytokine Signaling Is a Virulence Determinant of West Nile Virus

    Keller, Brian ChristopherUT Southwestern Medical Center2007

    … In particular, overexpression of various proteins from the pathogenic TX02 strain and the nonpathogenic MAD78 strain attenuated signaling to an IFN-responsive promoter, suggesting that viral products from both strains are capable of contributing to the IFN signal block. Differences between …

    utswmed Repository record

  5. Untersuchungen zur Modulation der IL-6-Signaltransduktion und zur Funktion der feed back Inhibitoren SOCS1 und SOCS3

    Sommer, UlrikePublikationsserver der RWTH Aachen University2003

    … expression of the feed back inhibitor SOCS3 in the early phase of differentiation. This would lead to the inhibition of IL-6 signalling. The second part of this thesis aimed at the characterization of the feed back inhibitors SOCS1 and SOCS3. It could be shown that endogenous SOCS3 is …

    aachen Repository record

  6. Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes

    Edwards, KatherineQueen's University Belfast2020

    … the role of suppressor of cytokine signalling (SOCS) proteins, which promote proteasomal degradation through ubiquitination, in regulating inflammasome activity. In this study SOCS2 and SOCS3 deficiency did not impact the inflammatory response to inflammasome-activating stimuli, including the …

    qu-belfast Repository record

  7. The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis

    Smith, Emily, Rigby, Rachael, Broughton, SusanLancaster University2016

    … cells. Suppressor of cytokine signalling 3 (SOCS3) is produced upon activation of the Janus kinase/Signal transducer and activator of transcription (Jak/Stat) pathway and this is an inducer of negative feedback inhibition and is implicated in regulation of intestinal homeostasis, with SOCS3 …

    lancaster Repository record