Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 621 for “"SNPs"”.
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Imputation of Microsatellite Markers With Tag SNPs
… human genome, Single Nucleotide Polymorphisms (SNPs) and Variable Number Tandem Repeat Polymorphisms (VNTRs), SNPs are much more easily and inexpensively assayed in a high-throughput manner. For this reason, we seek to explore methods that can allow us to use the more readily available SNP …
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Analysis of Coding Region SNPs and Its Propensity to Cause Disease
Single Nucleotide Polymorphisms or (SNPs) are the most abundant form of variation present in the human genome. These variations in individuals are considered to be the cause of diseases, difference in response to treatment, susceptibility to diseases or may have no impact. Association studies aim …
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Application of single nucleotide polymorphisms (SNPs) to forensic casework in Malaysia
… and analysis of single nucleotide polymorphisms (SNPs) have demonstrated the advantage of these markers over short tandem repeats (STRs) in that they only require small amplicons. However, before applying to casework, it is important to develop allele frequency databases from relevant populations. …
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Genotypes of SNPs of Key Genes Regulate Susceptibility and Drug Sensitivity to Neovascular AMD
… responses. Single nucleotide polymorphisms (SNPs), as primary genomic variations, are linked to disease susceptibility and treatment sensitivity, including in nAMD. This study posits that SNP interactions within human genes may influence anti-VEGF drug’s efficacy, supported by evidence on the …
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) which has a complex aetiology that involves the interplay of both genetic and environmental factors. Although more than 200 susceptibility loci have been identified through genome-wide …
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Using Synthetic Nanopores for Single -Molecule Analyses: Detecting SNPs, Trapping DNA Molecules, and the Prospects for Sequencing DNA
This work focuses on studying properties of DNA molecules and DNA-protein interactions using synthetic nanopores, and it examines the prospects of sequencing DNA using synthetic nanopores. We have developed a method for discriminating between alleles that uses a synthetic nanopore to measure the …
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Fatty acid metabolism and SNPs related to obesity in a longitudinal study of Swedish men: Predictors of metabolic syndrome
… between the single nucleotide polymorphisms (SNPs), on the SCD1 (stearoyl-CoA desaturase) gene and SNPs that had previously been associated with body mass index (BMI) or obesity in genome-wide association studies, with variables reflecting metabolic health. The variables reflecting metabolic …
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Individual genetic variations of eight SNPs associated with risk of obesity in preschool age children from STRONG Kids Program
… saliva samples and used for genotyping. Eight SNPs rs925946, rs1137101, rs8057044, rs6235, rs934778, rs2272382, rs7799039 and rs17782313 within or near the BDNF, LEPR, FTO, PCSK1, POMC, TUB, LEP, MC4R genes were genotyped by either FP-TDI assay or TaqMan SNP genotyping assay. Statistical …
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The identification of candidate genes using cDNA microarray and the analysis of two SNPs of the reelin gene in a South African austistic population
… The aims of the study were (i) to genotype two SNPs (exonic rs3622691 and intronic rs736707) in the RELN gene using Taqman® SNP Genotyping assays to detect association with autism in three distinct South African (SA) ethnic groups (Black, Caucasian and Mixed), and (ii) to detect candidate genes …
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Genomic characterization of the italian wolf (Canis lupus): the genes involved in black coat colour determination and application of microarray technique for snps detection.
… hand, we performed analysis on a high number of SNPs thanks to a customized Canine microarray useful to integrate or substitute the STR markers for genotyping individuals and detecting wolf-dog hybrids. Thanks to DNA microchip technology, we obtained an impressive amount of genetic data which …
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Genome-wide association mapping of temperature response in agronomically important traits of soybean
… high-quality single nucleotide polymorphisms (SNPs) is a powerful tool to associate markers and important traits. The aims of this study are: 1) to characterize the effects of low and high ambient temperature in soybean seed emergence and plant growth; and 2) to identify the genetic factors …
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Ranking single nucleotide polymorphisms with support vector regression in continuous phenotypes
… the ranking of single nucleotide polymorphisms (SNPs) over traditional chi-square tests in disease case studies [2]. In this investigation, ranking SNPs with support vector regression (SVR) was compared to the Wald test in predicting continuous phenotypes. SVR-ranked SNPs consistently …
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The Association of Single Nucleotide Polymorphisms (SNPs) in the Nitric Oxide Synthase 1 Adaptor Protein Gene (NOS1AP) and the QT Interval Duration Across Race/Ethnicity in Adults Without Clinical Cardiovascular Disease
… to study single nucleotide polymorphisms (SNPs) in NOS1AP for association with QT interval in an ethnically diverse cohort. Methods: Twenty-eight tagging SNPs, starting in the first intron and spanning the entire gene, were genotyped in 2847 men and women, age 45- 84 years, without known …
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Biological and Functional Consequences of Single Nucleotide Polymorphisms of the O6-Methylguanine-DNA-Methyltransferase Gene
Single nucleotide polymorphisms (SNPs) in DNA repair genes could alter the transcriptional levels, structure and function of DNA repair proteins and alter DNA repair proficiency. Consequently, these SNPs could significantly influence the level of genetic damage, which is an early critical factor in …
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Variable selection for generalized linear mixed models and non-Gaussian Genome-wide associated study data
… SNP has the characteristic that the number of SNPs is from hundred of thousands to millions. If p is the number of SNPs and n is the sample size, it is a p>>n variable selection problem. To solve this p>>n problem, the common method for GWAS is single marker analysis (SMA). However, since SNPs …
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Single Nucleotide Polymorphisms of the ATP1a2 gene and Their Effects on Blood Pressure and Other Cardiovascular Variable in African Americans and Caucasian Americans
… (CAs), 2) to test for association of these SNPs with baseline blood pressure, 3) to determine whether pressor responses of cardiovascular variables are affected by these SNPs, and 4) to test whether endothelial dysfunction is associated with these SNPs. RFLP analysis using the BglII …
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