Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"SNP Arrays"”.
-
Molecular cytogenetics and genetic characterisation of chromosomal rearrangements
… high density single nucleotide polymorphism (SNP) microarrays; Affymetrix 250K SNP microarrays (n=14) and Affymetrix SNP6.0 (n=2). Assuming complete penetrance, a critical region for congenitalheart disease (CHD) susceptibility gene was refined to approximately 200 kb and a candidate critical …
-
Development of new tools and germplasms for improvement of wheat resistance to Fusarium head blight
… and cultivars were genotyped using 90K wheat SNP arrays and phenotyped for the percentage of symptomatic spikelets (PSS), Fusarium damaged kernels (FDK) and deoxynivalenol (DON), a toxin produced by the pathogen. Genome-wide association studies (GWAS) identified significant trait associations …
-
Association of Differing Qatari Genotypes with Vitamin D Metabolites
… diabetes.Materials and Methods. Affymetrix 500k SNP arrays determined 398 Qataris genotype (mean age 49.8 years, 56.8% male; type 2 diabetes (T2DM) 220; control 178). LC-MS/MS analysis measured 1,25-dihydroxyvitamin-D (1,25(OH)2D), 25-hydroxyvitamin-D2 (25(OH)D2), 25-hydroxyvitamin-D3 (25(OH)D3), …
-
Bayesian Hidden Markov Models for finding DNA Copy Number Changes from SNP Genotyping Arrays
… CNVs from single nucleotide polymorphism (SNP) arrays. A Bayesian framework to reconstruct the DNA copy number sequence from the observed sequence of SNP array measurements is proposed. A Markov chain Monte Carlo (MCMC) algorithm, with a forward-backward stochastic algorithm for sampling …
-
Investigating the genetic diversity, population structure and archaic admixture history in worldwide human populations using high-coverage genomes
… diversity conforms with previous studies using SNP arrays and microsatellites, yet haplotype information reveals fine scale structures and recent demographic history that vary between populations. This dataset also provides a valuable opportunity to explore the diversity and distribution of …
-
Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… translocation cloning, expression analysis and SNP array analysis to detect regions of loss of heterozygosity (LOH). Thus far, by translocation cloning I have identified a previously undescribed partner gene fused to PDGFRB and two new PDGFRA fusion genes. I have also designed two reverse …
-
Genetic characterization of a dominant susceptible Rpp1 allele and analysis of quantitative resistance to Asian soybean rust
… was obtained from publicly available soybean 50K SNP arrays. Two different models were used for GWA: Mixed Linear Model (MLM) and FarmCPU. MLM did not identify any significant loci, but FarmCPU identified five significant loci. The five significant loci taken together explained 5% of the …
-
BIOLOGICAL AND MOLECULAR CHARACTERIZATION OF CMA-03/06, A NEWLY ESTABLISHED INTERLEUKIN-6 INDEPENDENT VARIANT OF THE CMA-03 HUMAN MYELOMA CELL LINE.
… of Affymetrix GeneChip Human Mapping 250K NspI arrays; copy number (CN) alterations were calculated using the DNAcopy Bioconductor package, based on circular binary segmentation method. Global gene expression profiling (GEP) was performed by means of the GeneChip Human Gene 1.0 ST Arrays …
-
Study of genetic by environmental interactions at transcriptomic and genomic levels
… use of dense single nucleotide polymorphisms (SNP) arrays that cover the bovine genome. One of the main goals is the identification of SNPs that show associations with economically important traits for the beef cattle industry. The largest variable cost in the beef cattle industry comes from …