Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"SNM1A"”.
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Structural and Functional Characterization of Human SNM1A
… quick removal and subsequent repair. Human SNM1A is a 5’-phosphate-dependent exonuclease that has been shown to be selectively involved in ICL repair; however the mechanism by which it processes ICL substrates remains unclear. To address this, our research is focused on the structural and …
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… of redundancy between FAN1 and the nuclease SNM1A/DCLRE1A, which has also been shown to process ICLs. Here, I describe a synergistic ICL repair deficiency phenotype in mouse embryonic fibroblasts derived from <em>Fan</em>1<sup>−/−</sup> <em>Snm1a</em><sup>−/−</sup> (dKO) mice, which exceeds …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… with Fanconi anemia proteins, yet redundant with SNM1A, an exonuclease that was previously implicated in ICL repair. Furthermore, the Fan1 knockout mouse model recapitulates many of the phenotypes observed in human KIN patients, including renal karyomegaly and liver dysfunction. Fan1-deficient …