Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"SNHL"”.
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
… VSs can lead to sensorineural hearing loss (SNHL), disequilibrium, facial nerve paralysis, and brainstem compression. Treatment options available today are associated with significant morbidity, leading to an unmet need for well-tolerated pharmacotherapies to curb VS growth and associated …
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Neural Encoding of Complex Signals in the Healthy and Impaired Auditory Systems
<p>Individuals with sensorineural hearing loss (SNHL) typically experience difficulty in understanding speech. Our current knowledge of deficits in speech perception and encoding consequent to SNHL is restricted to psychophysical studies in humans and single-unit experiments in animals. However, …
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Methods for robust characterization of consonant perception in hearing-impaired listeners
… with {\it sensorineural hearing loss} (SNHL) are prescribed hearing aids and/or a cochlear implant, based on their pure-tone threshold and speech perception scores. Although these assistive listening devices do help these individuals communicate in quiet surroundings, many still have …
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An in vivo study of GTF2IRD1 function and its contribution to the physical features of Williams Beuren Syndrome
… it is common to find sensorineural hearing loss (SNHL) and a characteristic set of facial features. The gene GTF2IRD1, first discovered in our laboratory, and the adjacent, homologous gene GTF2I, both fall within the WBS deletion region. Haploinsufficiency of the transcriptional regulators they …
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Adenoviral Mediated Gene Delivery to Human Umbilical Cord Mesenchymal Stromal Cells for Inner Ear Hair Cell Differentiation
… of hearing loss. Sensory neural hearing loss (SNHL) is the most common form, which results from degeneration of inner ear sensory hair cells and auditory neurons in the cochlea. In recent years, there has been an increasing interest in gene delivery to mesenchymal stem cells. Gene delivery …
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Vestibular Evoked Myogenic Potentials and Postural Control in Adults with Age-Related Hearing Loss
… dysfunction in ARHL and other types of SNHL. The long-term goal of this line of this study is to evaluate the use of auditory function as a predictor of increased risk of falls and a possible criterion for subsequent balance function testing and intervention as needed as a means to …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… VS-associated sensorineural hearing loss (SNHL) remain largely unresolved. In the recent years, environmental cues such as electromagnetic fields (EMFs) have been suggested as one of the potential co-factor influencing SC behaviour, but their cellular impact and the molecular mechanisms …
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Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2B Signaling
… mice, we used aged mice as an additional SNHL model. Aging organs have been associated with hypoxia and, consequently, increased adenosine levels. Indeed, we found that aged <em>Adora2b</em><sup>-/-</sup> rescued hearing sensitivity. Moreover, we used a therapeutic approach for both models …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
Arenaviruses are viruses that can cause severe and deadly hemorrhagic fever infections in Africa and South America, including Lassa virus that causes Lassa fever in several countries in west Africa. There are currently no vaccines and very limited therapeutics available for Lassa fever. There are …
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Effectiveness of different medical interventions implemented when a change in hearing status is detected during ototoxicity monitoring
… highfrequency (HF) sensorineural hearing loss (SNHL). The impact of hearing loss (HL) due to aminoglycoside-induced cochleotoxicity can influence a patient's communication, psychological, physical functioning and overall well-being negatively and lead to a reduced quality of life (QoL). To …
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Ideal characteristics of a listening device
… mild to moderate sensorineural hearing losses (SNHL) (Urbanski Dana et al., 2021). In summary, prioritising the expansion of innovative hearing technologies should be a central policy concern to comprehensively address untreated hearing loss. Aim: The aim was to determine what factors could …