Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"SNF"”.
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Strategies to Prevent Hospital Transfers in the SNF Environment
… any changes of medical condition within the SNF microsystem. In this project, the CNL functions as the team manager and care coordinator. The CNL facilitated, and utilized patients’ outcome data to make changes in care processes to reduce acute hospital transfers in the skilled nursing …
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SWI/SNF COMPLEXES COORDINATE WITH HISTONE MODIFICATIONS TO REGULATE CHROMATIN REMODELING
SWI/SNF, the founding member of ATP dependent chromatin remodelers and its paralog RSC in yeast perform similar yet distinct functions inside the cell. In vitro these complexes use ATP dependent DNA translocation to either mobilize or disassemble nucleosomes. However, how these complexes interact …
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Engineering Cell Lines to Investigate the Function of Mammalian SWI/SNF Complexes
Mammalian SWI/SNF complexes belong to the class of chromatin remodelling complexes, and consist of approximately 15 subunits. Bioinformatics analyses of tumour sample sequencing studies have shown that members of the mSWI/SNF complexes are mutated in almost 20% of all cases, suggesting many …
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Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
… replication. SWItch/Sucrose Non-Fermenting (SWI/SNF) complexes are a family of chromatin remodellers that are conserved across eukary- otes. Mutations in subunits of SWI/SNF complexes cause a multitude of different developmental disorders including Coffin-Siris syndrome, Nicolaides-Baraitser syn- …
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The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease
… studies have implicated multiple subunits of SWI/SNF complexes in human neurodevelopmental and psychiatric disorders, as well as in cancers. Particularly haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling subunit, has been implicated in short stature, autism spectrum disorder, …
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AN INSIGHT INTO DIFFERENT MODES OF REMODELER REGULATION: FOCUS ON SACCHAROMYCES CEREVISIAE SWI/SNF
… we have addressed these questions using the SWI/SNF remodeler from budding yeast (Saccharomyces cerevisiae) to explore how different remodelers compare to SWI/SNF in terms of nucleosome interaction. Using a chemical based histone – remodeler photo-crosslinking and labeling approach, we show that …
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Optimization of Thermoelectric Generators to Power Monitoring Platforms of SNF Canister Internal Conditions: Numerical Simulations
Spent nuclear fuel (SNF) may need to be stored in dry storage systems (DSS) for longer times than the systems were originally licensed for. Therefore, it is important to monitor the internal conditions of these canisters to ensure that their components and contents remain safe. The overall …
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THE INTERPLAY OF HISTONE CHAPERONE NAP1 WITH SWI/SNF FAMILY OF CHROMATIN REMODELLERS IN S.cerevisiae
… disassembly. We have previously shown that SWI/SNF has the ability to mediate disassembly of a dinucleosome substrate in a two step process. The first step in this process is the displacement of one H2A-H2B dimer that occurs rapidly, followed by a slower step in which the remaining hexasome is …
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STRUCTURAL AND FUNCTIONAL DELINEATION OF SUBUNITS AND DOMAINS IN THE SACCHAROMYCES CEREVISIAE SWI/SNF COMPLEX
… been addressed using the prototype remodeler SWI/SNF from budding yeast. ySWI/SNF is a 12 subunit complex that includes the catalytic subunit Swi2/Snf2. It affects 6% of the yeast genome being primarily involved in gene activation. We employed a systematic protein or domain deletion strategy and …
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Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma
SWI/SNF related ATP-dependent chromatin remodelling complexes act to regulate chromatin accessibility, ensuring that genes are regulated appropriately. Components of the complexes are mutated in approximately 20% of human cancers. PBRM1 is one of defining subunits of the PBAF subtype of SWI/SNF …
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SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION
… Illinois University Carbondale. TITLE: SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION MAJOR PROFESSOR: Dr. Blaine Bartholomew The SWI/SNF complex disrupts and mobilizes chromatin in an ATP-dependent …
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LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1
Caenorhabditis elegans BLMP-1 is the ortholog of the human zinc finger and SET domain-containing transcriptional repressor BLIMP1/PRDM1. BLIMP1/PRDM1 and its orthologs are well studied as transcriptional repressors in many species including humans and mice. Interestingly, we found that in C. …
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THE CELL CYCLE GENES REGULATION OF IPS CELLS AND THE ROLE OF SWI/SNF CHROMATIN REMODELING ENZYMES DURING THEM DIFFERENTIATION
Lo stato di cellula pluripotente può essere raggiunto con l'espressione ectopica di alcuni fattori di trascrizione che possono riprogrammare le cellule somatiche. (Takahashi, K., e Yamanaka, S., 2006; Takahashi, K., e Yamanaka, S., 2007).
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… involved in gene activation and repression. SWI/SNF ATP-dependent chromatin remodelling complexes contain either BRG1 or BRM as the core ATPase together with other common and variable subunits. BRG1 is required for terminal epidermal differentiation in mice and humans and for hair follicle stem …
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Post-acute care transitions for adults with serious mental illness
… Medicare beneficiaries experience a hospital to SNF transition each year. Despite their frequent occurrence, transitions across levels and locations of care are incredibly error prone, poorly coordinated and communicated, and often result in cyclical patterns of hospital readmission. This is …
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Conceptual Development of Remote Monitoring System for Pressurized Water Reactor Spent Fuel Dry Cask Storage Through Neutron and Gamma Transport Simulations
… for safeguarding spent nuclear fuel (SNF) stored in dry cask storage facilities and for maintaining persistent continuity of knowledge (CoK) about it. The current safeguards approach relies heavily upon containment and surveillance measures, where seals are placed inside and outside …
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Translated Evidence-Based Mental Health Toolkit for Skilled Nursing Facilities
… term care (LTC) in a skilled nursing facility (SNF) (Grabowski, Aschbrenner, Feng, & Mor, 2009). Residents who live in SNFs may experience limited access to meaningful occupations. The SNFs’ institutionalized structure may perpetuate a lack of autonomy and stigma for residents with a SMI …
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Creating Focused Occupational Therapy Interventions for Clients with Heart Failure in Skilled Nursing Facilities
<p>The ultimate goal of the SNF is to help clients stabilize their medical conditions and attain their therapy goals so that they can return home (Orr, Boxer, Dolansky, Allen, & Forman, 2016). However, approximately 27% of heart failure (HF) clients are readmitted to the hospital after being …
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Examination of discharge settings and readmission rates following hospitalization for total knee arthroplasty
… settings include skilled nursing facilities (SNFs) and home- and community-based rehabilitation. We used Medicare data from beneficiaries who received TKA to examine 1) time trends in hospital discharge settings and 30-day readmission rates by discharge setting, 2) predictors of hospital …
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