Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"SNAREs"”.
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Fences & Fault-lines, Deadfalls & Snares
… of poems, Fences & Fault-lines, Deadfalls & Snares, attempts to chart the hierarchies mapped in the English language. Those in power–governments, churches, movements, militaries, businesses–manipulate our language to bait us, the threat of violence hanging overhead like a dead weight. Or …
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Fences & Fault-lines, Deadfalls & Snares
… of poems, Fences & Fault-lines, Deadfalls & Snares, attempts to chart the hierarchies mapped in the English language. Those in power–governments, churches, movements, militaries, businesses–manipulate our language to bait us, the threat of violence hanging overhead like a dead weight. Or …
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SNAREs in evoked and spontaneous neurotransmission
Der SNARE-Komplex, bestehend aus Synaptobrevin-2, SNAP-25 und Syntaxin-1 ist unabdingbar für evozierte synaptische Übertragung, allerdings ist der Einfluss der möglichen Intermediärstadien des SNARE-Komplexes in den verschiedenen Phasen der synaptischen Übertragung unbekannt. Mittels Mutagenese von …
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Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
… deutet. Proteinmengen von untersuchten SNAREs waren in Vti1a-defizienten Geweben nicht beeinträchtigt, was jedoch eine mögliche Kompensierung der Vti1a-Defizienz durch diese Proteine nicht ausschließen kann. Außerdem wurde gezeigt, dass Syntaxin 8 (Qc) in Vti1b-defizienten Zellen in …
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Determining the Roles of Q-SNAREs in Mast Cell Tumor Necrosis Factor Exocytosis
… mast cell TNF secretion. To explore the roles to SNAREs in TNF release in mast cells, I used Stx2 KO BMMCs as well as Stx3 and Stx11 KD RBL-2H3 cells in secretion assays to determine the consequences of depleting these isoforms on TNF secretion. The resulting data indicates that while Stx2 KO does …
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Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… factor attachment protein receptors (SNAREs) complex. The proteins in this complex reside on the vesicle membrane (synaptotagmin 1 and synaptobrevin/vesicle-associated membrane protein, which is also known as VAMP) and the plasma membrane (syntaxin 1 and synaptosomal associated protein …
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Einfluss der endo-lysosomalen Qb-SNAREs Vti1a und Vti1b auf die subzelluläre Sortierung sowie auf signalgebende Prozesse im zentralen Nervensystem der Maus
… the driving force necessary for fusion. The Qb-SNAREs Vti1a and Vti1b are known to be implicated in several endo-lysosomal fusion processes. In mice, the single knockout of either Vti1a or Vti1b is associated with only minor phenotypic alterations, whereas the double knockout of both SNAREs …
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Unraveling the Role of SNARE Interactions in Neurotransmitter Release
… 1 and SNAP-25, which are collectively known as SNAREs and form a tight complex (the core complex). The assembly of the core complex may mediate membrane fusion. Complexin is a highly conserved cytoplasmic protein that binds tightly to the SNARE complex. Analysis of the interaction between …
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Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
… zwischen den plasmamembranständigen SNAREs Syntaxin1A und SNAP-25 und dem vesikelassoziierten SNARE Synaptobrevin. Dadurch werden die gegenüberliegenden Membranen fusioniert. Neben den SNAREs ist auch Munc18-1, das zur Sec1/Munc18-Proteinfamilie gehört, ein essentielles Protein der …
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Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
… zwischen den plasmamembranständigen SNAREs Syntaxin1A und SNAP-25 und dem vesikelassoziierten SNARE Synaptobrevin. Dadurch werden die gegenüberliegenden Membranen fusioniert. Neben den SNAREs ist auch Munc18-1, das zur Sec1/Munc18-Proteinfamilie gehört, ein essentielles Protein der …
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SNARE specificity in membrane protein traffic
Recent findings indicate that there is a role for SNAREs in ion channel regulation. With the discovery of the vesicle trafficking SNARE protein NtSYP121 came the development of the predicted cytosolic domain fragment of the protein. This Sp2 fragment was found in studies to block the responses of …
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Mutational analysis of the Vam3 transmembrane domain and its effects on vacuole fusion in Saccharomyces cerevisiae
… specific Vam3 TMD interactions with its cognate SNAREs, or a combination of both, result in the less efficient fusion with Vam3-CCIIM. In this study, I further studied the Vam3-CCIIM vacuole fusion and vacuole morphology. To test the above hypotheses, I constructed truncations at the C-terminus …
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Charakterisierung von SNARE-Proteinen in der Hefe Saccharomyces cerevisiae
… wobei sie Komplexe bilden in denen jeweils 3 Q-SNAREs mit einem R-SNARE interagieren. Im ersten Teil der Dissertation wurde über einen Multicopy-Suppressor-Screen versucht, zusätzliche Proteine aufzufinden, die mit dem Hefe-Q-SNARE Vti1p im Transport vom trans-Golgi zur Prävakuole oder zur …
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Spatial distribution and intensity of snare poaching in the Boland region of South Africa: implications for optimising anti-poaching efforts
… of bushmeat. In South Africa, illegal wire-snares are the most popular method of bushmeat harvesting. However, snare poaching is indiscriminate and inhumane, causing the death of many non-target species and suffering by all animals captured. The impacts of snaring on an ecosystem can be …
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Charakterisierung eines Proteinkomplexes in Säugerzellen, der am Transport zwischen Membrankompartimenten beteiligt ist.
… Der Komplex müsste analog zur Hefe aus folgenden SNAREs bestehen: mSec22b als R-SNARE und Syntaxin18, mUse1 und mSec20 als Q-SNAREs. Obwohl ein solcher Komplex von der 1R-3Q Regel abweicht, die zuvor für andere SNARE-Komplexe beschrieben wurde, konnte er in dieser Arbeit durch Fluoreszenzmessungen …
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Dynamics and Fate of the inner Membrane Complex in Apicomplexan Parasites
… classification of apicomplexan putative SNAREs (25 In T. gondii, 24 in P. falciparum). Functional predictions based on SNARE motif and subcellular localization reveals conservation of SNAREs involved in the early secretory pathway, highlighting the stripped-down apicomplexan endomembrane …
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Molecular Mechanisms Controlling Synaptic Vesicle Fusion
… favored process. Because the zippering of SNAREs is spontaneous, fusion events occur immediately upon a vesicle interacting with its target membrane. But, in certain circumstances, such as in synaptic vesicles, spontaneous fusion is not desired, so a clamp protein is necessary to prevent …
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Structural and Functional Studies of Munc18 and SNARE Proteins
… factor attachment protein receptors) families. SNAREs function by forming a four-helix bundle called SNARE complex; assembly of the SNARE complex brings two membranes together and is key for membrane fusion. The function of SM proteins is less clear. The neuronal SM proteins Munc18-1 was …
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