Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"SNARE proteins"”.
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Structural and Functional Studies of Munc18 and SNARE Proteins
… Essential components of this machinery are proteins from the Sec1/Munc18 (SM) and SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) families. SNAREs function by forming a four-helix bundle called SNARE complex; assembly of the SNARE complex brings two membranes …
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Re-localization of SNARE proteins in mouse sperm prior to the acrosome reaction
The principal role of SNARE proteins is to arbitrate vesicle fusion to a target membrane. Formation of tripartite SNARE protein complexes between SNARE proteins on opposing membranes is the minimal requirement for membrane fusion. The SNARE protein family is large, consisting of more than 60 …
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Cryo-electron Microscopy of Reconstituted Membrane Fusion Systems
… factor attachment protein receptor (SNARE) proteins are responsible for driving the fusion of biological membranes and are present across many different cell trafficiking systems. Synaptic SNARE proteins allow the release of neurotransmitters across synaptic clefts by promoting the …
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Regulation of membrane fusion by Tlg2p & Vps45p through the endosomal system of Saccharomyces cerevisiae
SNARE proteins are essential components of the machinery that facilitates membrane fusion in eukaryotic cells. SNARE proteins are subject to multiple levels of regulation, one of which is imbedded in the syntaxin (Qa-SNARE) molecule. It has been demonstrated that some syntaxins adopt a closed …
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Regulation of SNARE-dependent fusion in an in vitro system
… Central to this machinery are members of the SNARE (soluble NSF attachment protein receptor) family of proteins. The process of SNARE-mediated membrane fusion needs to be tightly regulated and the SNARE proteins are partially responsible for the specificity in communication between eukaryotic …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… lipid rafts. Numerous signaling and transport proteins have been found to be targeted to lipid raft microdomains, where the function of the associated membrane proteins could be distinctly regulated. I have identified the expression of lipid raft constituent proteins, caveolin-1/2 in pancreatic …
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The Functional Organization of Synaptic Vesicle Pools In A Retinal Bipolar Neuron
… vesicle fusion at these synapses is the role of SNARE (Soluble N-ethylmaleimide sensitive factor Attachment Protein Receptor) proteins. Vesicles at conventional neurons undergo SNARE complex-mediated fusion. However a recent study has suggested that ribbon synapses involved in hearing can operate …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
… synapses in the retina do not contain the t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor) syntaxin 1A that is found in conventional synapses of the nervous system. In contrast, ribbon synapses of the mammalian retina contain the related isoform, syntaxin …
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Synaptic structure and function at the Drosophila larval neuromuscular junction : a molecular analysis of complexin and radish
… the formation of a parallel four-helix bundle of SNARE proteins that are present on both the vesicular (v-SNAREs) and target plasma membranes (t-SNAREs). The full zippering of this bundle is thought to provide the driving force for membrane fusion. At synapses, vesicle fusion is exquisitely …
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Palmitoylation and Oxidation of the Cysteine Rich Region of SNAP-25 and their Effects on Protein Interactions
… performed within the central nervous system. The SNARE hypothesis points to a family of proteins that are thought to enable the membrane fusion that leads to exocytosis. The secondary structure of SNAP-25 is unique among SNARE proteins in that it has two alpha helical SNARE motifs and a cysteine …
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Competition Between Synaptotagmin 1 and Complexin for SNARE Complex Binding, Controls Fast Synaptic Vesicle Exocytosis
… vesicles that were primed for release by SNARE complex assembly. Besides synaptotagmin 1, fast Ca2+- triggered exocytosis requires complexins. Synaptotagmin 1 and complexins both bind to assembled SNARE complexes, but it is unclear how their functions are coupled. To clarify previous …
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Analysis of Synaptotagmin-SNARE Complex Interactions by One-Dimensional NMR Spectroscopy
… neurotransmitter release is mediated by numerous proteins at the neuronal synapse. The SNARE proteins form a complex that mediates fusion between the synaptic vesicle and plasma membrane. The protein synaptotagmin-1 is the major sensor for the calcium concentration. Synaptotagmin-1 and the SNARE …
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The Role of β-synuclein in the Pathological Mechanisms of Dementia with Lewy Bodies
… Further examination of key pre-synaptic SNARE proteins reveal an increase of VAMP2 in the frontal cortex and a decrease of VAMP2 and SNAP25 in the occipital cortex. Autophagy markers LC3-II and p62 were also increased in the frontal cortex where an increase in β-synuclein was identified …
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Biochemical Analysis of SNARE Protein Interactions – Role of Transmembrane Domain
SNARE (soluble NSF attachment protein receptor) Proteine umfassen verschiedene Familien von Proteinen, welche in Eukaryonten von der Hefe bis hin zum Menschen vorkommen. Sie sind für die Membranfusion bei zellulären Prozessen, wie Vesikeltransport, Neurotransmitterausschüttung oder …
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Electrofusion of Escherichia coli with Giant Lipid Vesicles and the Compaction of Escherichia coli Nucleoid
… by mimicking natural fusogenic molecules called SNARE proteins, which are capable of selectively adhering cells/vesicles and even inducing the fusion of the adhered membranes. However, the fusion efficiency of such SNARE-inspired DNA nanodevice is not high especially where the size of the …
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The Role of Munc18 Proteins in Physiologic and Pathologic Exocytoses in the Pancreatic Acinar Cell
… specific interactions between distinct sets of SNARE proteins forming exocytotic complexes, whose assembly is modulated by distinct Munc18 proteins. The Munc18 isoform responsible for these exocytotic events in the acinar cell is unknown. Here, I postulate Munc18b to regulate apical exocytosis …
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Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
… sensitive factor Attachment protein REceptor (SNARE) complex where intertwined helix bundles provide energy to fuse lipid membranes. Furthermore, this process is regulated by indispensable proteins such as Munc18 and Munc13 through physically interacting with SNARE proteins. Disruption of …
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Structural and Functional Studies of C2-Domain Proteins Involved In Neurotransmitter Release
… To achieve this exquisite regulation, many proteins are involved. The central fusion machinery includes the SNARE proteins synaptobrevin, syntaxin and SNAP-25, as well as Munc18. Besides these universal components, many other neuronal specific proteins are also involved in regulating …
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Structural and Functional Studies of the Munc13 MUN Domain and the RIM C2B Domain
… through exocytosis of synaptic vesicles. Many proteins are involved the regulation of neurotransmission. The central fusion machinery includes the SNARE proteins and Munc18- 1. Besides these universal components, many other neuronal specific proteins are also involved in regulating …
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Dynamics and Fate of the inner Membrane Complex in Apicomplexan Parasites
… intimately associated with cytoskeletal proteins. The IMC is highly dynamic, and its assembly, disassembly and localization within the parasite are critical for many important functions, including parasite motility, maintenance of structural integrity, and partitioning maternal organelles …
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