Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"SNAI1"”.
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Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… focuses on identifying the DUBs of EZH2 and SNAI1, two proteins critical for cancer progression and metastasis, and establishing these DUBs as promising anti-cancer targets.</p> <p>EZH2, the catalytic component of the PRC2 complex, silences gene transcription by histone methylation. High …
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The regulation of LIV-1 mRNA in MDA-MB-231 human breast cancer cells and its association with E-cadherin (CDH1)
… linkage between LIV-1 and CDH1, expression of SNAI1, thought to be a transcriptional repressor of CDH1, was measured. However, neither EGF nor LIV-1 knockdown altered the expression of SNAI1 suggesting that this factor does not mediate influences of LIV-1 on CDH1 in these cells. We next …
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Understanding Human Astrovirus from Pathogenesis to Treatment
… HAstV-induced EMT as an upregulation of SNAI1 and VIM with a down regulation of CDH1 and OCLN, loss of cell-cell junctions most notably at 18 hours post-infection (hpi), and loss of cellular polarity by 24 hpi. While active transforming growth factor- (TGF-) increases during HAstV …
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The role of BET proteins in castration-resistant prostate cancer dissemination
… through the transcriptional regulation of AHNAK, SNAI1 and SNAI2, which are EMT genes linked to promotion of metastasis in a diverse set of cancers. Furthermore, treatment of CRPC cell lines with low doses of MZ1, a small-molecule, BRD4-selective degrader, inhibits EMT and metastatic potential. …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… for immune-lazer capture microscopy. SMAD3, SNAI1, TGFβ and IL6 were all numerically raised in EMT/S100A4+ve regions however the small subset sample numbers did not offer enough statistical power for the study. Primary fibroblast cultures released cytokines IL6, IL8 and TGFβ dose dependently …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… dual-luciferase reporter assay identified that SNAI1 mRNA directly bound to HuR through an AU-rich elements (AREs) dependent way. The data demonstrated that inhibition of HuR destabilized SNAI1 mRNA, and subsequently reduced Snail protein levels, resulting in the EMT and CSCs inhibition in …
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
… repressors of E-cadherin (ZEB1, ZEB2, TWIST, SNAI1 and SNAI2). Recent publications highlight the role of microRNAs belonging to the miR-200 family and miR-205 in preventing EMT through suppression of ZEB1 and ZEB2. p53, the homologue of p63, is implicated in regulating EMT by modulating the …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… Vcan, Has2, Itgα5; transcription factors Snai1 and Twist, and signaling molecules Bmp2, Bmp7, Notch2, Jag1 and Wnt2In addition, we show that the canonical Wnt signaling pathway contributes to the vessel-forming potential of the allantois. Ex vivo, the Tbx4 mutant phenotype can be rescued …
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Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer
… of particular interest in this project is SNAI1 (Snail). It is therefore the goal of this project to understand the growth, makeup and metastatic ability of HGSOC cell lines to test possible strategies to decrease growth of cancer and prevent metastasis.</p> <p>In this thesis project the …
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Genotoxic remodeling of the host epithelium
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01