Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"SN-38"”.
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Investigations into the Mechanisms that Are Responsible for Reduction in Colonic SN-38 Exposure
… population due to the high accumulation of SN-38 in colon. It has been hypothesized that multiple factors, such as higher biliary excretion of SN-38 and SN-38 glucuronide mediated through different efflux transporters, deglucuronidation of SN-38 glucuronide to SN-38 by bacterial …
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Synthesis and Characterization of Redox-Sensitive Polymer and Prodrug for Targeted Drug Delivery
… redox-sensitive self-immolative polymer, and DNS-SN38, thiol-sensitive SN-38 prodrug, as potential candidates for targeted drug delivery platforms. By covalently conjugating a redox-trigger (p-nitrobenzyl alcohol) and self-immolative linker (p-hydroxybenzyl alcohol) to the cyclization spacer …
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Lymphocyte-mediated drug nanoparticle delivery to disseminated lymphoma tumors in vivo
… system loaded with the topoisomerase I poison SN-38. We then generated in vitro-activated primary murine T cell carriers using optimized culture conditions that induced robust proliferation and high expression levels of CD62L for lymph node homing. The dox liposomes and SN-38 nanoparticles were …
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Engineered Polydopamine Nanocarriers for Biomedical Applications
… capacity for the potent chemotherapeutic agent SN-38, they demonstrated significantly enhanced ultrasound-mediated drug release compared to solid-core nanoparticles. As a result, cytotoxicity studies revealed a 20% increase in the efficacy of SN-38@hPDA nanocarriers in pancreatic ductal …
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Molecular Considerations In The Design Of Novel Alpha/Beta Hydrolase Inhibitors
… treatment of colorectal cancer is metabolized to SN-38, the active drug metabolite, by two CE isozymes CES1 (localized in the liver) and CES2 (localized in the small intestines). CES2's ability to activate irinotecan at a faster rate than CES1 creates a localization of activated SN-38 in the gut …
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Synthetic strategies for control of structure from individual macromolecules to nanoscale materials to networks
… different drugs (telmisartan, paclitaxel, and SN-38) and three different drug loadings. Combinations of these macromonomers were then allowed to self assemble into micellar aggregates. The size, stability, and shape of these micellar aggregates were controlled with the highly versatile …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… an increase in sensitivity to both topotecan and SN-38, the active moiety of the prodrug irinotecan. In addition, we overexpressed MRP4 in NB1643, which resulted in increased topotecan resistance.</p> <p>The NB1691 cell lines with reduced MRP4 expression were subsequently transplanted as …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… is a prodrug which is converted in vivo to SN-38, via metabolism by carboxylesterase (CE) enzymes. St. Jude Children’s Research Hospital researchers have designed a two-pronged protocol of tumor-targeted CPT-11 chemotherapy combining the complementary approaches of a) specific modulation of …