Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"SMRT"”.
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Conjoint- und Discrete-Choice-Analyse als Präferenzmessmodelle zur Beurteilung des präventivmedizinischen Risikoverhaltens - Theorie und computergestützte Umsetzung unter Verwendung von SMRT
… über die einzelnen Module des Statistikprogramms SMRT folgt die Beschreibung der Datenerhebung, bevor in der deskriptiven Analyse und der Schätzung, Simulation und Konstruktion weiterführender Kennzahlen die eigentliche Auswertung der Empirie zu finden ist. In der Entscheidung für monetäre oder …
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Identification of acyl transferases responsible for the diverse hydroxycinnamoyl chemical space in bidens pilosa
… To achieve this, a Single Molecule Real Time (SMRT) sequencing approach was used to establish the full-length gene transcripts, in attempt to identify the acyl transferase Executive summary xi responsible for chlorogenic acids production in B. pilosa. The SMRT sequencing technique has brought a …
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Evaluating the population control of invasive crayfish using removals and male sterilisation.
… of large males (Sterile Male Release Technique: SMRT) using both field studies (on the River Barle, Devon, Southern England) and laboratory-based experiments in controlled conditions. In the laboratory experiments, no differences were found in the ability of sterilised males to win dominance …
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Molekulární mechanismy indukce apoptosy u nádorových buněk
… V našem případě jsme indukovali buněčnou smrt u nádorových buněk deprivací železa, klinicky používanými taxany (paclitaxel, docetaxel) a nově syntetisovanými fotosensitivními látkami. Z presentovaných publikací jsme získali tyto závěry. (1) Studie týkající se indukce apoptosy deprivací …
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Regulation of Secretory Phospholipase A2 by Thyroid Hormone
… mediator for retinoid and thyroid receptors (SMRT) by siRNA blocked the T3 inhibition of PLA2g2a. Using chromatin immunoprecipitation assays, I showed that NCoR1 and SMRT were associated with the PLA2g2a gene in the presence of T3.</p> <p>Conclusion: The thyroid hormone status modulates the …
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Read alignment using deep neural networks
… technologies are Oxford Nanopore and PacBio SMRT sequencing, which are considered top players because of their extremely long reads and low cost. However, the reads may contain error up to 20% that are not generally uniformly distributed. To deal with that level of error rate and read length, …
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
… with other co-repressors such as SIN3, N-CoR and SMRT, and histone deacetylases. The objective of this thesis was to investigate the role of the ETO-homologues in hematopoiesis and leukemia. First, the finding of physical interactions between ETO homologues suggested a possible cooperation. …
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Understanding The Mechanism and Extent of Vlse Recombination In Borrelia Burgdorferi Using Next-Generation Sequencing
… Analysis of PacBio single molecule real-time (SMRT) sequencing indicated the presence of 0.84% to 1.18% variants in pure<em> in vitro </em>cultures and 0.79% to 1.22% in tissue explants, as compared 36% to 57% for organisms from mouse bladder tissue 7 days post inoculation. Statistical …
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Small Angle X-ray Scattering study of conformational changes in steroid responsive activator (SRA) RNA upon binding with suppressor protein SHARP
… by suppressive RNA binding proteins like the SMRT/HDAC1-associated repressor protein (SHARP), which binds the STR7 domain of SRA RNA through its four RNA recognition motifs (RRMs); it is not fully understood how SHARP executes this role as there are no SRA RNA-SHARP structures available for …
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Investigation and application of methods for ancient DNA research
… Pacific Bioscience’s Single Molecule Real-Time (SMRT) sequencing prove to be unsuccessful and genotyping of ancient bison aDNA with the BovineSNP50 BeadChip generated inconsistent results. Furthermore, a hybridization capture probe design was tested and found to be unsuitable for aDNA enrichment. …
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Structural and thermal properties of graphene - boron nitride superlattice
… theory (DFPT) and single–mode relaxation time (SMRT) approximation to the phonon Boltzmann transport equation, thermal transport property of one such stable structure is studied. Acoustic mismatch between graphene and boron nitride introduces wave interference effects (such as opening of phonon …
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Covalent DNA Modifications in Phage and Bacterial Dynamics
… Pacific Bioscience single-molecule real-time (SMRT) sequencing to yield information about genome sequences and covalent modifications. Using computational methods we identified seven bacterial contigs and one phage contig with CRISPR arrays targeting phage contigs. This suggests that both …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
… stabilizing its interaction with the corepressor SMRT. CPA production inhibits the PPAR! target-gene transcription that normally drives adipocytic differentiation of 3T3-L1 cells, lipid accumulation in RAW264.7 cells and primary mouse macrophages, and arterial wall remodeling in vivo. Inhibition …
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Molekulární mechanismy indukce programované buněčné smrti v nádorových buňkách.
Nádorová onemocnění jsou v dnešní době třetí nejčastější příčinou úmrtí (20 % všech úmrtí). Proto je důležité najít nové způsoby jak nádorové buňky účinně a specificky likvidovat a nejslibnější cestou je cílená terapie. Jedním z nejčastěji deregulovaných protoonkogenů v nádorových buňkách je C-MYC, …