Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"SMO"”.
-
Studies of Smoothened in Hedgehog Signaling Pathway
… transducer, the seven-transmembrane protein Smoothened (Smo) is highly regulated. It is still a mystery how Smo transduces graded Hh signal to downstream components. Although Smo shares some structural similarity with G protein coupled receptors (GPCR), there is little evidence that G …
-
Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
… with numerous cancer and tumor conditions. The Smoothened (Smo) G protein coupled receptor (GPCR) functions as the signal transducer of the Hh pathway and is the most attractive drug target of the pathway. The structure of the Smo receptor includes seven membrane spanning domains, extracellular …
-
Chemically Based Interrogation of Smoothened, a Proto-Oncogenic Component of the Hedgehog Signal Transduction Pathway
… of the seven transmembrane oncoprotein, Smoothened (Smo). Thus, Smo is a high priority therapeutic target in Hh-associated cancers including basal cell carcinoma (BCC) and medulloblastoma. While a Smo antagonist is now approved for the management of BCC, therapeutic strategies focused on …
-
Decentralized sliding mode control and estimation for large-scale systems
… mode control (SMC) and sliding mode observers (SMO) theory based on a linear matrix inequality (LMI) approach. A complete theory of decentralized first order sliding mode theory is developed. The main developments proposed in this thesis are: The novel development of an LMI approach to …
-
Non-silicon Microfabricated Nanostructured Chemical Sensors For Electric Nose Application
… Nanocrystalline semiconductor metal oxide (SMO) materials include SnO2, WO3 and In2O3 have been studied for gas sensing applications. Different doping material such as copper, silver, platinum and indium are studied in order to achieve better selectivity for different targeting toxic gases …
-
Activation mechanisms of non-class A G protein-coupled receptors
… activation mechanisms of Class F receptor Smoothened (SMO), six class B1 GPCRs - Glucagon receptor (GCGR), Glucagon-like Peptide 1 receptor (GLP1R), Parathyroid Hormone 1 receptor (PTH1R), Secretin Receptor (SCTR) and Pituitary Adenylate Cyclase 1 receptor (PAC1R), and fungal Class D …
-
Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
… antifungal agent that has been found to inhibit Smoothened (SMO), a crucial G protein-coupled receptor located on the cell membrane and becomes activated on the primary cilium, which allows initiation of HH pathway signaling. We hypothesize that components of the HH pathway are overexpressed in …
-
Growth, decay, and change: Organizations in the contemporary women's movement in Buenos Aires, Argentina
… we can understand social movement organization (SMO) growth, decay, and change. First, hierarchy does have its benefits for SMOs, but it is not the only means by which SMOs survive, remain active, and grow. Second, the way that SMOs actively structure participation (with decisions about SMO …
-
Authorship Attribution on the Enron Email Corpus
… Three analysis methods: WEKA RandomForest, WEKA SMO, and Centroid with Cosine Distance were used. Results showed that the Large test set gave the best authorship classification, followed by the Medium, then the Small and the Tiny test sets. WEKA SMO gave better authorship classification than WEKA …
-
OPTIMAL ANTENNA DESIGNS FOR WIRELESS COMMUNICATION APPLICATIONS
… applications. Spider Monkey Optimization (SMO) method is introduced for the first time for solving electromagnetic problems. The SMO is a new swarm intelligence technique which models the foraging behavior of spider monkeys. To show the efficiency of the SMO, different examples are …
-
Power Analysis and Prediction for Heterogeneous Computation
… linear regression, KNN, bagging, random forest, SMO regression, decision tree, and neural networks) in predicting GPU power consumption at different frequencies. Our study shows that a support vector machine-aided regression model (i.e., SMO regression) achieves the highest accuracy with a mean …
-
Neural Population Dynamics Underlying Encoding of Time in the Cortico-Striatal Circuit
… were found in the secondary motor cortex (sMO-d1St). We discovered that this cortical neuron population carries relevant information about perceived time intervals by forming coordinated neuronal ensembles, referred to as timing ensembles. Importantly, these neuronal ensembles exhibited …
-
Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… Έγινε μελέτη της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και αυξημένα ποσοστά ενεργοποίησής του. Επίσης βρέθηκε στατιστικά σημαντική συσχέτιση με τα πλακώδη καρκινώματα και με τα χαμηλού grade καρκινώματα. …
-
Assessing the effect of psychological priming techniques on salivary hormones and physical performance markers
… being observed virtually via social media (SMO) was also investigated. While warming up, subjects were observed, salivary testosterone and cortisol concentration levels and a subsequent 65% 1RM back squat exercise to repetition failure were tested to assess whether these primers affect a …
-
The transcription factor Zfx is required for tumorigenesis caused by Hedgehog pathway activation
… These targets included the Hh signal transducer Smoothened (Smo). Smo expression data from Zfx-deficient BCC and MB cells in vivo and in vitro suggest that Zfx may directly regulate Hh pathway activation in some cancers. We identified two additional conserved downstream targets of Zfx, Dis3L and …
-
Printable and Machine Intelligent 0D/2D Materials Gas Sensor Arrays
… gas sensors based on semiconducting metal oxide (SMO) suffer notably from high power consumption, slow response, poor sensitivity, and baseline drift at room temperature. In this thesis, I present printable and hybrid aerogels as high-performance GSAs. These sensors, based on graphene and …
-
Distributed Support Vector Machine With Graphics Processing Units
… problem. Sequential Minimal Optimization (SMO) is a decomposition-based algorithm which breaks this large QP problem into a series of smallest possible QP problems. However, it still costs O(n2) computation time. In our SVM implementation, we can do training with huge data sets in a …
-
Papel de los fibroblastos peritumorales en la progresión del cáncer de páncreas humano: estudio del gen erizo
… en los fibroblastos peritumorales de SMO y BMP7, y la sobreexpresión de SMO activa la vía del gen erizo y favorece la progresión tumoral. Creamos un modelo animal de cáncer de páncreas humano con tamaño tumoral mayor y más metástasis en el modelo de xenotrasplante de CAPAN1 y …
-
Plasma modification of metal oxides and textiles: tailoring surface properties for improved gas sensor and protective clothing applications
… modification of semiconducting metal oxides (SMO) to create gas sensors that are more responsive to a target gas at lower operating temperatures. First, SnO2 nanoparticles (NP) supported by a traditional substrate (ZrO2 wafer) were treated with a CO or CO2 plasma as a function of applied …
-
Collective action for the rights of sex offenders: evaluating social movement organizations
… of 19 of these social movement organizations (SMO) to explore the organizations' structure and resources, and the strategies they use to achieve desired policy outcomes. Three social movement theories guided this investigation: resource mobilization, cultural cognitive approaches and political …
Page 1 of 2