Global ETD Search
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Showing 1 to 20 of 34 for “"SMAD3"”.
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… embryonic lethality, whereas global loss of Smad3 protects mice against diet-induced obesity and the direct contributions of Smad2 and Smad3 in adipose tissues individually or in combination and the responses of these tissues to activin signaling are unknown. Additionally, our lab …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
… dependent. To do this we created 2 colonies of Smad3 mice. One colony was housed with normal colonic bacteria (Smad3-uninfected animals) and the other colony (Smad3-infected animals) had chronic H. hepaticus infection. As previously seen the Smad3⁻/⁻- infected animals developed colitis and …
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SMAD2, SMAD3 et SARA : des facteurs clés de la signalisation du TGFβ impliqués dans l’invasion des cellules cancéreuses stimulée par le microenvironnement hypoxique
… principaux de la signalisation du TGF SMAD2 et SMAD3, jouent des rôles opposés dans l’invasion des cellules cancéreuses : SMAD2 agissant comme inhibiteur, et SMAD3 promouvant la production d’invadopodes. Ces rôles opposés peuvent être attribués à la modulation de gènes cibles distincts par SMAD2 …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
… approaches. I found that ZNF165 associates with SMAD3, a key signal transducing factor in the TGFβ pathway, to modulate transcription of TGFβ-dependent genes and thereby promote growth and survival of human TNBC cells. Importantly, my data demonstrate that through functioning as a cofactor for …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… in most cell types this response is mediated by Smad3– dependent regulation of c–Myc, p15<super>Ink4B</super>, and p21<super>Cip1</super> transcription, studies from Smad3 null mice suggest that TGF–β–induced growth inhibition in B lymphocytes occurs regardless of Smad3 status. We prove that this …
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
… of the TGF-β1 downstream intracellular mediator SMAD3 (p-SMAD3), compared to the peri-nuclear localisation of p-SMAD3 observed in the untreated and pindolol-treated cells. Furthermore, TGF-β1 inhibition with LY2109761 (25μM) in isoprenaline-treated EBs restored the peri-nuclear localisation of …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… functional TrkA receptors triggers activation of Smad3. This NGF-dependent Smad activation occurs by a mechanism which is different from being induced by TGF-ß receptors in that it provokes a different phosphorylation pattern of R-Smads. Together with an inferior role of TßRI, Smad3 is proposed to …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… protein expression of PKC-β1, PKC-δ, and phospho-Smad3. TGF-β1 increased the chloride channel activity of the eosinophils, which was blocked by rottlerin. TGF-β1 induced chemotaxis of eosinophils, which was blocked by rottlerin, DIDS and NPPB. Eosinophil shape change occurred after TGF-β1 …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… C3 is up-regulated by iron in RPE cells. ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-δ (C/EBP-δ) are part of a non-canonical TGF-β signaling pathway that is responsible for iron-induced C3 expression. Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… reporter activity, reduce the phosphorylation of SMAD3 proteins, and decrease the expression of pai-1 transcript. These green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 mitogen-activated protein kinase proteins and promoted BMP4-induced SMAD-dependent by …
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The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… of TGF-β-driven EMT through inhibition of SMAD3. Studies have now demonstrated that induction of EMT promotes acquisition of stem/progenitor cell properties, further adding to the repertoire of cellular regulation by EMT mediators.</p> <p>I demonstrate that loss of DEAR1 in human mammary …
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The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… expression of collagen type I, TGF-ß1, smad3 and smad7 after incubation with exogenous TGF-ß1 13 IV. DISCUSSION 17 V. CONCLUSION 22 REFERENCES 23 국문요약 28
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
… how TGF-β induced nuclear trafficking of Smad3 and Smad4, and phosphorylation of Smad2 are affected during in vitro progression. We did not find any consistent decrease in protein expression of Smad2, Smad3 or Smad4; or increase in protein expression of inhibitory Smad7 that paralleled the …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… by transcriptionally inducing miR203 through Smad3. Modulating NUDT21 by overexpression or antagomiR203 attenuated NUDT21 reduction-mediated fibrosis in vitro. The results of this dissertation are significant in that these findings broaden our understanding on the role of APA in fibrosis. The …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… canonical transforming growth factor β (TGFβ)-SMAD3 pathway. This study has revealed the significant contribution of the non-canonical pathways including the Hippo pathway to the development of hepatic fibrosis. HSC-specific Sirt6 deficient mice developed severe fibrosis when fed a …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
… immunoblotting to evaluate TGFβ1-induced Smad3 phosphorylation and Daf expression in mouse myotubes. We demonstrated repression of phosphorylated-Smad3, a marker of the canonical TGFβ1 pathway, in OP-MG versus control MG fibroblasts after treatment with TGFβ1. We also demonstrated that …
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… achieves this primarily by transcription factor SMAD3, which acts on specific genetic elements to regulate gene expression, most of which are distal enhancers. These suggest that enhancers play essential roles in HSC gene deregulation and liver fibrosis. However, it remains underexplored in terms …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… downstream of TGF-b, we found that while Smad2, Smad3 and Smad4 are required for the generation of iTreg cells, only Smad2 is indispensable for the induction of IL-17-producing cells, suggesting that TGF-b induces these T helper lineages through differential signaling pathways. Thus, our findings …
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Pleiotropy in complex traits
… robust evidence for association with OA at the SMAD3 locus, which is known to play a role in bone remodeling and cartilage maintenance. My second project aimed to elucidate the increased prevalence of type 2 diabetes (T2D) in schizophrenia (SCZ) patients. I used GWAS summary statistics of SCZ …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… for immune-lazer capture microscopy. SMAD3, SNAI1, TGFβ and IL6 were all numerically raised in EMT/S100A4+ve regions however the small subset sample numbers did not offer enough statistical power for the study. Primary fibroblast cultures released cytokines IL6, IL8 and TGFβ dose …
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