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Showing 1 to 20 of 41 for “"SMAD3"”.
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… embryonic lethality, whereas global loss of Smad3 protects mice against diet-induced obesity and the direct contributions of Smad2 and Smad3 in adipose tissues individually or in combination and the responses of these tissues to activin signaling are unknown. Additionally, our lab …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
… dependent. To do this we created 2 colonies of Smad3 mice. One colony was housed with normal colonic bacteria (Smad3-uninfected animals) and the other colony (Smad3-infected animals) had chronic H. hepaticus infection. As previously seen the Smad3⁻/⁻- infected animals developed colitis and …
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SMAD2, SMAD3 et SARA : des facteurs clés de la signalisation du TGFβ impliqués dans l’invasion des cellules cancéreuses stimulée par le microenvironnement hypoxique
… principaux de la signalisation du TGF SMAD2 et SMAD3, jouent des rôles opposés dans l’invasion des cellules cancéreuses : SMAD2 agissant comme inhibiteur, et SMAD3 promouvant la production d’invadopodes. Ces rôles opposés peuvent être attribués à la modulation de gènes cibles distincts par SMAD2 …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
… smooth muscle actin. Cellular localization of Smad3 proteins was demonstrated by immunohistochemistry. RT-PCR for Smad2, 3, 4 and Smad7 was conducted with total RNA and Northern blot analysis for Smad3 and 7 with mRNA. Whole liver lysates were prepared to detect Smad4 by Western blotting. …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
… approaches. I found that ZNF165 associates with SMAD3, a key signal transducing factor in the TGFβ pathway, to modulate transcription of TGFβ-dependent genes and thereby promote growth and survival of human TNBC cells. Importantly, my data demonstrate that through functioning as a cofactor for …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… in most cell types this response is mediated by Smad3– dependent regulation of c–Myc, p15<super>Ink4B</super>, and p21<super>Cip1</super> transcription, studies from Smad3 null mice suggest that TGF–β–induced growth inhibition in B lymphocytes occurs regardless of Smad3 status. We prove that this …
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Einfluss von BMP-7 und Endoglin auf den TGF-beta Signalweg bei fibrosierenden Lebererkrankungen
… ALK5. As a consequence of activation of the ALK5/Smad3 pathway the Collagen I expression is induced and as a consequence of the ALK1/Smad1/5 pathway a transient expression of Id-1 is induced. The BMP-7 signal is exclusively mediated through Smad1/5 and results in long term Id-1 expression. While …
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
… of the TGF-β1 downstream intracellular mediator SMAD3 (p-SMAD3), compared to the peri-nuclear localisation of p-SMAD3 observed in the untreated and pindolol-treated cells. Furthermore, TGF-β1 inhibition with LY2109761 (25μM) in isoprenaline-treated EBs restored the peri-nuclear localisation of …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… functional TrkA receptors triggers activation of Smad3. This NGF-dependent Smad activation occurs by a mechanism which is different from being induced by TGF-ß receptors in that it provokes a different phosphorylation pattern of R-Smads. Together with an inferior role of TßRI, Smad3 is proposed to …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… protein expression of PKC-β1, PKC-δ, and phospho-Smad3. TGF-β1 increased the chloride channel activity of the eosinophils, which was blocked by rottlerin. TGF-β1 induced chemotaxis of eosinophils, which was blocked by rottlerin, DIDS and NPPB. Eosinophil shape change occurred after TGF-β1 …
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Lösliches Endoglin (sCD105) : diagnostische Wertigkeit bei chronischen Lebererkrankungen und funktionelle Bedeutung für die Signaltransduction von transforming growth factor (TGF-beta)
… expressed soluble endoglin on TGF-b1/Smad3 signaling by using an artificial reporter system for the detection of phosphorylated Smad3, i.e. (CAGA)12-MLP Luc. For the evaluation of sCD105 as a marker for the occurence of HCC in high-risk patients, we measured the concentration of sCD105 …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… C3 is up-regulated by iron in RPE cells. ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-δ (C/EBP-δ) are part of a non-canonical TGF-β signaling pathway that is responsible for iron-induced C3 expression. Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… reporter activity, reduce the phosphorylation of SMAD3 proteins, and decrease the expression of pai-1 transcript. These green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 mitogen-activated protein kinase proteins and promoted BMP4-induced SMAD-dependent by …
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The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… of TGF-β-driven EMT through inhibition of SMAD3. Studies have now demonstrated that induction of EMT promotes acquisition of stem/progenitor cell properties, further adding to the repertoire of cellular regulation by EMT mediators.</p> <p>I demonstrate that loss of DEAR1 in human mammary …
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The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… expression of collagen type I, TGF-ß1, smad3 and smad7 after incubation with exogenous TGF-ß1 13 IV. DISCUSSION 17 V. CONCLUSION 22 REFERENCES 23 국문요약 28
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
… how TGF-β induced nuclear trafficking of Smad3 and Smad4, and phosphorylation of Smad2 are affected during in vitro progression. We did not find any consistent decrease in protein expression of Smad2, Smad3 or Smad4; or increase in protein expression of inhibitory Smad7 that paralleled the …
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Unterschiede in der TGF-[beta]-vermittelten Signaltransduktion in aktivierten hepatischen Sternzellen unterhalb der Smad2-Phosphorylierung
… displayed constitutively phosphorylated Smad3, whose origin remains to be determined and functional relevance is discussed. We conclude, that regulation of TGF-beta actions in activated HSC is complex and involves multiple signaling pathways. Depending on the target gene, different signal …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… by transcriptionally inducing miR203 through Smad3. Modulating NUDT21 by overexpression or antagomiR203 attenuated NUDT21 reduction-mediated fibrosis in vitro. The results of this dissertation are significant in that these findings broaden our understanding on the role of APA in fibrosis. The …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… canonical transforming growth factor β (TGFβ)-SMAD3 pathway. This study has revealed the significant contribution of the non-canonical pathways including the Hippo pathway to the development of hepatic fibrosis. HSC-specific Sirt6 deficient mice developed severe fibrosis when fed a …
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